Vitamin D in Corona Virus Disease 2019 (COVID-19) Related Multisystem Inflammatory Syndrome in Children (MIS-C)
Multisystem Inflammatory Syndrome in children (MIS-C) is a rare but devastating complication of coronavirus disease 19 (COVID-19). The development of prognostic biomarkers and more importantly the implementation of new treatment modalities would have a significant impact in clinical practice regardi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.648546/full |
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| author | Gavriela Feketea Gavriela Feketea Vasiliki Vlacha Ioana Corina Bocsan Emilia Vassilopoulou Luminita Aurelia Stanciu Mihnea Zdrenghea Mihnea Zdrenghea |
| author_facet | Gavriela Feketea Gavriela Feketea Vasiliki Vlacha Ioana Corina Bocsan Emilia Vassilopoulou Luminita Aurelia Stanciu Mihnea Zdrenghea Mihnea Zdrenghea |
| author_sort | Gavriela Feketea |
| collection | DOAJ |
| description | Multisystem Inflammatory Syndrome in children (MIS-C) is a rare but devastating complication of coronavirus disease 19 (COVID-19). The development of prognostic biomarkers and more importantly the implementation of new treatment modalities would have a significant impact in clinical practice regarding the outcome of MIS-C. Vitamin D could be a potential candidate. In this mini review we analyze the immunomodulatory role of vitamin D in viral infections and specifically in COVID-19. We also examine the current literature regarding the association of vitamin D with MIS-C and Kawasaki disease. The vitamin D was evaluated not only as a biomarker but also as a nutritional supplement. We concluded that vitamin D levels could be valuable in predicting severe forms of MIS-C and correction of abnormal levels in severe MIS-C may influences its evolution. 25-hydroxyvitamin D3 [25(OH)D3] supplementation raising serum [25(OH)D] concentrations potentially have a favorable effect in reducing the severity of MIS-C in certain circumstances. Further studies are needed to confirm these results. |
| first_indexed | 2024-12-14T17:52:51Z |
| format | Article |
| id | doaj.art-f559c90368374f778e5de53d54f1593a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-14T17:52:51Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f559c90368374f778e5de53d54f1593a2022-12-21T22:52:37ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-03-011210.3389/fimmu.2021.648546648546Vitamin D in Corona Virus Disease 2019 (COVID-19) Related Multisystem Inflammatory Syndrome in Children (MIS-C)Gavriela Feketea0Gavriela Feketea1Vasiliki Vlacha2Ioana Corina Bocsan3Emilia Vassilopoulou4Luminita Aurelia Stanciu5Mihnea Zdrenghea6Mihnea Zdrenghea7Department of Hematology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, RomaniaDepartment of Pediatrics, Pediatric Allergy Outpatient Clinic, “Karamandaneio”, Children Hospital, Patras, GreeceDepartment of Early Years Learning and Care, University of Ioannina, Ioannina, GreeceDepartment of Pharmacology, Toxicology and Clinical Pharmacology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, RomaniaDepartment of Nutritional Sciences and Dietetics International Hellenic University, Thessaloniki, GreeceNational Heart and Lung Institute, Imperial College London, London, United KingdomDepartment of Hematology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, RomaniaIon Chiricuta Oncology Institute, Cluj-Napoca, RomaniaMultisystem Inflammatory Syndrome in children (MIS-C) is a rare but devastating complication of coronavirus disease 19 (COVID-19). The development of prognostic biomarkers and more importantly the implementation of new treatment modalities would have a significant impact in clinical practice regarding the outcome of MIS-C. Vitamin D could be a potential candidate. In this mini review we analyze the immunomodulatory role of vitamin D in viral infections and specifically in COVID-19. We also examine the current literature regarding the association of vitamin D with MIS-C and Kawasaki disease. The vitamin D was evaluated not only as a biomarker but also as a nutritional supplement. We concluded that vitamin D levels could be valuable in predicting severe forms of MIS-C and correction of abnormal levels in severe MIS-C may influences its evolution. 25-hydroxyvitamin D3 [25(OH)D3] supplementation raising serum [25(OH)D] concentrations potentially have a favorable effect in reducing the severity of MIS-C in certain circumstances. Further studies are needed to confirm these results.https://www.frontiersin.org/articles/10.3389/fimmu.2021.648546/fullvitamin D25(OH)D3SARS-CoV-2 infectionCOVID-19multisystemKawasaki syndrome-like |
| spellingShingle | Gavriela Feketea Gavriela Feketea Vasiliki Vlacha Ioana Corina Bocsan Emilia Vassilopoulou Luminita Aurelia Stanciu Mihnea Zdrenghea Mihnea Zdrenghea Vitamin D in Corona Virus Disease 2019 (COVID-19) Related Multisystem Inflammatory Syndrome in Children (MIS-C) Frontiers in Immunology vitamin D 25(OH)D3 SARS-CoV-2 infection COVID-19 multisystem Kawasaki syndrome-like |
| title | Vitamin D in Corona Virus Disease 2019 (COVID-19) Related Multisystem Inflammatory Syndrome in Children (MIS-C) |
| title_full | Vitamin D in Corona Virus Disease 2019 (COVID-19) Related Multisystem Inflammatory Syndrome in Children (MIS-C) |
| title_fullStr | Vitamin D in Corona Virus Disease 2019 (COVID-19) Related Multisystem Inflammatory Syndrome in Children (MIS-C) |
| title_full_unstemmed | Vitamin D in Corona Virus Disease 2019 (COVID-19) Related Multisystem Inflammatory Syndrome in Children (MIS-C) |
| title_short | Vitamin D in Corona Virus Disease 2019 (COVID-19) Related Multisystem Inflammatory Syndrome in Children (MIS-C) |
| title_sort | vitamin d in corona virus disease 2019 covid 19 related multisystem inflammatory syndrome in children mis c |
| topic | vitamin D 25(OH)D3 SARS-CoV-2 infection COVID-19 multisystem Kawasaki syndrome-like |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.648546/full |
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