The genetic causes of male infertility: a Middle East and North Africa perspective [version 2; peer review: 2 approved]
Male infertility is attributable to 60% of total infertility cases and about 30-50% of these cases remain idiopathic. In the Middle East and North Africa region (MENA), male infertility affects about 22.6% of men of reproductive age. Male infertility is caused by a variety of factors, including endo...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2022-06-01
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| Series: | F1000Research |
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| Online Access: | https://f1000research.com/articles/11-125/v2 |
| _version_ | 1811221700113596416 |
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| author | Mouhammad Halabi Ruthwik Duvuru Stefan S. Du Plessis Temidayo S. Omolaoye |
| author_facet | Mouhammad Halabi Ruthwik Duvuru Stefan S. Du Plessis Temidayo S. Omolaoye |
| author_sort | Mouhammad Halabi |
| collection | DOAJ |
| description | Male infertility is attributable to 60% of total infertility cases and about 30-50% of these cases remain idiopathic. In the Middle East and North Africa region (MENA), male infertility affects about 22.6% of men of reproductive age. Male infertility is caused by a variety of factors, including endocrine disruption, exposure to toxins, lifestyle, genetic and epigenetic modifications. Genetic modifications, including chromosomal abnormalities, chromosomal rearrangements, Y chromosome microdeletions and single-gene mutations, explain for about 10-15% of infertility cases. Since genetic aberration is a key player in the pathogenesis of male infertility, it is important to explore the impact in the MENA region due to the high incidence of male infertility. Therefore, the current study aims to systematically analyse the literature regarding the impact and common causes of male infertility in the MENA region. To achieve this aim, a comprehensive literature search was performed on PubMed, Google Scholar, and Science Direct databases. Following the search, a total of 126 articles was retrieved, of which 12 were duplicates and another 69 articles did not meet the inclusion criteria, totaling the exclusion of 81 articles. Studies excluded were those that had patient populations originating outside the MENA region, review articles, non-English written articles, or studies where the patient population was under 18 years of age. Findings showed that the frequent genetic aberration leading to male infertility in these regions include Y chromosome microdeletions, gene polymorphisms or copy number variations, mitochondrial microdeletions and other genetic deletions or mutations. In lieu of this, diverse clinical genetic tests should be made available for the proper diagnosis of male infertility. |
| first_indexed | 2024-04-12T08:05:04Z |
| format | Article |
| id | doaj.art-f55b1aa7632245c585b07966846cdd26 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-04-12T08:05:04Z |
| publishDate | 2022-06-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-f55b1aa7632245c585b07966846cdd262022-12-22T03:41:12ZengF1000 Research LtdF1000Research2046-14022022-06-0111134493The genetic causes of male infertility: a Middle East and North Africa perspective [version 2; peer review: 2 approved]Mouhammad Halabi0Ruthwik Duvuru1https://orcid.org/0000-0003-2490-8139Stefan S. Du Plessis2Temidayo S. Omolaoye3https://orcid.org/0000-0001-7661-7718School of Medicine, Royal College of Surgeons, Ireland-Bahrain, Busaiteen, BahrainCollege of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Health Care City, Dubai, 505055, United Arab EmiratesCollege of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Health Care City, Dubai, 505055, United Arab EmiratesCollege of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Health Care City, Dubai, 505055, United Arab EmiratesMale infertility is attributable to 60% of total infertility cases and about 30-50% of these cases remain idiopathic. In the Middle East and North Africa region (MENA), male infertility affects about 22.6% of men of reproductive age. Male infertility is caused by a variety of factors, including endocrine disruption, exposure to toxins, lifestyle, genetic and epigenetic modifications. Genetic modifications, including chromosomal abnormalities, chromosomal rearrangements, Y chromosome microdeletions and single-gene mutations, explain for about 10-15% of infertility cases. Since genetic aberration is a key player in the pathogenesis of male infertility, it is important to explore the impact in the MENA region due to the high incidence of male infertility. Therefore, the current study aims to systematically analyse the literature regarding the impact and common causes of male infertility in the MENA region. To achieve this aim, a comprehensive literature search was performed on PubMed, Google Scholar, and Science Direct databases. Following the search, a total of 126 articles was retrieved, of which 12 were duplicates and another 69 articles did not meet the inclusion criteria, totaling the exclusion of 81 articles. Studies excluded were those that had patient populations originating outside the MENA region, review articles, non-English written articles, or studies where the patient population was under 18 years of age. Findings showed that the frequent genetic aberration leading to male infertility in these regions include Y chromosome microdeletions, gene polymorphisms or copy number variations, mitochondrial microdeletions and other genetic deletions or mutations. In lieu of this, diverse clinical genetic tests should be made available for the proper diagnosis of male infertility.https://f1000research.com/articles/11-125/v2male infertility chromosomal abnormalities MENA gene deletion gene mutation; Y chromosome microdeletion.eng |
| spellingShingle | Mouhammad Halabi Ruthwik Duvuru Stefan S. Du Plessis Temidayo S. Omolaoye The genetic causes of male infertility: a Middle East and North Africa perspective [version 2; peer review: 2 approved] F1000Research male infertility chromosomal abnormalities MENA gene deletion gene mutation; Y chromosome microdeletion. eng |
| title | The genetic causes of male infertility: a Middle East and North Africa perspective [version 2; peer review: 2 approved] |
| title_full | The genetic causes of male infertility: a Middle East and North Africa perspective [version 2; peer review: 2 approved] |
| title_fullStr | The genetic causes of male infertility: a Middle East and North Africa perspective [version 2; peer review: 2 approved] |
| title_full_unstemmed | The genetic causes of male infertility: a Middle East and North Africa perspective [version 2; peer review: 2 approved] |
| title_short | The genetic causes of male infertility: a Middle East and North Africa perspective [version 2; peer review: 2 approved] |
| title_sort | genetic causes of male infertility a middle east and north africa perspective version 2 peer review 2 approved |
| topic | male infertility chromosomal abnormalities MENA gene deletion gene mutation; Y chromosome microdeletion. eng |
| url | https://f1000research.com/articles/11-125/v2 |
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