Drug approval prediction based on the discrepancy in gene perturbation effects between cells and humansResearch in context

Drug approval prediction based on the discrepancy in gene perturbation effects between cells and humansResearch in context

Summary: Background: Poor translation between in vitro and clinical studies due to the cells/humans discrepancy in drug target perturbation effects leads to safety failures in clinical trials, thus increasing drug development costs and reducing patients’ life quality. Therefore, developing a predic...

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Bibliographic Details
Main Authors: Minhyuk Park, Donghyo Kim, Inhae Kim, Sin-Hyeog Im, Sanguk Kim
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:EBioMedicine
Subjects:
Machine learning
Drug approval
Drug safety
Clinical translation
Gene perturbation effect
Discrepancy
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396423002700

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