Effect of the Camelid’s Seminal Plasma Ovulation-Inducing Factor/β-NGF: A Kisspeptin Target Hypothesis
Female mammals are classified into spontaneous and induced ovulators based on the mechanism eliciting ovulation. Ovulation in spontaneous species (e.g., human, sheep, cattle, horse, pigs, and most rodents) occurs at regular intervals and depends upon the circulating estradiol. However, in induced ov...
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Frontiers Media S.A.
2017-06-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fvets.2017.00099/full |
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| author | Khalid El Allali Najlae El Bousmaki Najlae El Bousmaki Hassan Ainani Hassan Ainani Valérie Simonneaux |
| author_facet | Khalid El Allali Najlae El Bousmaki Najlae El Bousmaki Hassan Ainani Hassan Ainani Valérie Simonneaux |
| author_sort | Khalid El Allali |
| collection | DOAJ |
| description | Female mammals are classified into spontaneous and induced ovulators based on the mechanism eliciting ovulation. Ovulation in spontaneous species (e.g., human, sheep, cattle, horse, pigs, and most rodents) occurs at regular intervals and depends upon the circulating estradiol. However, in induced ovulators (e.g., rabbits, ferrets, cats, and camelids), ovulation is associated with coitus. In the later, various factors have been proposed to trigger ovulation, including auditory, visual, olfactory, and mechanic stimuli. However, other studies have identified a biochemical component in the semen of induced ovulators responsible for the induction of ovulation and named accordingly ovulation-inducing factor (OIF). In camelids, intramuscular or intrauterine administration of seminal plasma (SP) was shown to induce the preovulatory luteinizing hormone (LH) surge followed by ovulation and subsequent formation of corpus luteum. Recently, this OIF has been identified from SP as a neurotrophin, the β subunit of nerve growth factor (β-NGF). β-NGF is well known as promoting neuron survival and growth, but in this case, it appears to induce ovulation through an endocrine mode of action. Indeed, β-NGF may be absorbed through the endometrium to be conveyed, via the blood stream, to the central structures regulating the LH preovulatory surge. In this review, we provide a summary of the most relevant results obtained in the field, and we propose a working hypothesis for the central action of β-NGF based on our recent demonstration of the presence of neurons expressing kisspeptin, a potent stimulator of GnRH/LH, in the camel hypothalamus. |
| first_indexed | 2024-12-21T04:29:26Z |
| format | Article |
| id | doaj.art-f55cb63a050544bea2093a6932ed19e4 |
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| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-12-21T04:29:26Z |
| publishDate | 2017-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-f55cb63a050544bea2093a6932ed19e42022-12-21T19:15:59ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692017-06-01410.3389/fvets.2017.00099272074Effect of the Camelid’s Seminal Plasma Ovulation-Inducing Factor/β-NGF: A Kisspeptin Target HypothesisKhalid El Allali0Najlae El Bousmaki1Najlae El Bousmaki2Hassan Ainani3Hassan Ainani4Valérie Simonneaux5Comparative Anatomy Unit/URAC49, Department of Biological and Pharmaceutical Veterinary Sciences, Hassan II Agronomy and Veterinary Medicine Institute, Rabat, MoroccoComparative Anatomy Unit/URAC49, Department of Biological and Pharmaceutical Veterinary Sciences, Hassan II Agronomy and Veterinary Medicine Institute, Rabat, MoroccoDepartment of Neurobiology of Rhythms, CNRS UPR 3212, Institute of Cellular and Integrative Neurosciences, University of Strasbourg, Strasbourg, FranceComparative Anatomy Unit/URAC49, Department of Biological and Pharmaceutical Veterinary Sciences, Hassan II Agronomy and Veterinary Medicine Institute, Rabat, MoroccoDepartment of Neurobiology of Rhythms, CNRS UPR 3212, Institute of Cellular and Integrative Neurosciences, University of Strasbourg, Strasbourg, FranceDepartment of Neurobiology of Rhythms, CNRS UPR 3212, Institute of Cellular and Integrative Neurosciences, University of Strasbourg, Strasbourg, FranceFemale mammals are classified into spontaneous and induced ovulators based on the mechanism eliciting ovulation. Ovulation in spontaneous species (e.g., human, sheep, cattle, horse, pigs, and most rodents) occurs at regular intervals and depends upon the circulating estradiol. However, in induced ovulators (e.g., rabbits, ferrets, cats, and camelids), ovulation is associated with coitus. In the later, various factors have been proposed to trigger ovulation, including auditory, visual, olfactory, and mechanic stimuli. However, other studies have identified a biochemical component in the semen of induced ovulators responsible for the induction of ovulation and named accordingly ovulation-inducing factor (OIF). In camelids, intramuscular or intrauterine administration of seminal plasma (SP) was shown to induce the preovulatory luteinizing hormone (LH) surge followed by ovulation and subsequent formation of corpus luteum. Recently, this OIF has been identified from SP as a neurotrophin, the β subunit of nerve growth factor (β-NGF). β-NGF is well known as promoting neuron survival and growth, but in this case, it appears to induce ovulation through an endocrine mode of action. Indeed, β-NGF may be absorbed through the endometrium to be conveyed, via the blood stream, to the central structures regulating the LH preovulatory surge. In this review, we provide a summary of the most relevant results obtained in the field, and we propose a working hypothesis for the central action of β-NGF based on our recent demonstration of the presence of neurons expressing kisspeptin, a potent stimulator of GnRH/LH, in the camel hypothalamus.http://journal.frontiersin.org/article/10.3389/fvets.2017.00099/fullovulation-inducing factorβ-NGFcamelidscamelovulationseminal plasma |
| spellingShingle | Khalid El Allali Najlae El Bousmaki Najlae El Bousmaki Hassan Ainani Hassan Ainani Valérie Simonneaux Effect of the Camelid’s Seminal Plasma Ovulation-Inducing Factor/β-NGF: A Kisspeptin Target Hypothesis Frontiers in Veterinary Science ovulation-inducing factor β-NGF camelids camel ovulation seminal plasma |
| title | Effect of the Camelid’s Seminal Plasma Ovulation-Inducing Factor/β-NGF: A Kisspeptin Target Hypothesis |
| title_full | Effect of the Camelid’s Seminal Plasma Ovulation-Inducing Factor/β-NGF: A Kisspeptin Target Hypothesis |
| title_fullStr | Effect of the Camelid’s Seminal Plasma Ovulation-Inducing Factor/β-NGF: A Kisspeptin Target Hypothesis |
| title_full_unstemmed | Effect of the Camelid’s Seminal Plasma Ovulation-Inducing Factor/β-NGF: A Kisspeptin Target Hypothesis |
| title_short | Effect of the Camelid’s Seminal Plasma Ovulation-Inducing Factor/β-NGF: A Kisspeptin Target Hypothesis |
| title_sort | effect of the camelid s seminal plasma ovulation inducing factor β ngf a kisspeptin target hypothesis |
| topic | ovulation-inducing factor β-NGF camelids camel ovulation seminal plasma |
| url | http://journal.frontiersin.org/article/10.3389/fvets.2017.00099/full |
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