Dihydroartemisinin-piperaquine effectiveness for seasonal malaria chemoprevention in settings with extended seasonal malaria transmission in Tanzania
Abstract Effectiveness of dihydroartemisinin-piperaquine (DP) as seasonal malaria chemoprevention (SMC) was assessed in Nanyumbu and Masasi Districts. Between March and June 2021, children aged 3–59 months were enrolled in a cluster randomized study. Children in the intervention clusters received a...
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Nature Portfolio
2024-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-52706-z |
| _version_ | 1827329255521910784 |
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| author | Richard Mwaiswelo Billy Ngasala Frank Chaky Fabrizio Molteni Ally Mohamed Samwel Lazaro Bushukatale Samwel Bruno P. Mmbando |
| author_facet | Richard Mwaiswelo Billy Ngasala Frank Chaky Fabrizio Molteni Ally Mohamed Samwel Lazaro Bushukatale Samwel Bruno P. Mmbando |
| author_sort | Richard Mwaiswelo |
| collection | DOAJ |
| description | Abstract Effectiveness of dihydroartemisinin-piperaquine (DP) as seasonal malaria chemoprevention (SMC) was assessed in Nanyumbu and Masasi Districts. Between March and June 2021, children aged 3–59 months were enrolled in a cluster randomized study. Children in the intervention clusters received a monthly, 3-days course of DP for three consecutive months regardless of malaria infection status, and those in the control clusters received no intervention. Malaria infection was assessed at before the first-round and at 7 weeks after the third-round of DP in both arms. Malaria prevalence after the third-round of DP administration was the primary outcome. Chi-square tests and logistic regression model were used to compare proportions and adjust for explanatory variables. Before the intervention, malaria prevalence was 13.7% (161/1171) and 18.2% (212/1169) in the intervention and control clusters, respectively, p < 004. Malaria prevalence declined to 5.8% (60/1036) in the intervention clusters after three rounds of DP, and in the control clusters it declined to 9.3% (97/1048), p = 0.003. Unadjusted and adjusted prevalence ratios between the intervention and control arms were 0.42 (95%CI 0.32–0.55, p < 0.001) and 0.77 (95%CI 0.53–1.13, p = 0.189), respectively. SMC using DP was effective for control of malaria in the two Districts. Trial registration: NCT05874869, https://clinicaltrials.gov/ 25/05/2023. |
| first_indexed | 2024-03-07T15:31:14Z |
| format | Article |
| id | doaj.art-f55d598bbae5471e92da656988b4e878 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:31:14Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-f55d598bbae5471e92da656988b4e8782024-03-05T16:27:44ZengNature PortfolioScientific Reports2045-23222024-01-0114111110.1038/s41598-024-52706-zDihydroartemisinin-piperaquine effectiveness for seasonal malaria chemoprevention in settings with extended seasonal malaria transmission in TanzaniaRichard Mwaiswelo0Billy Ngasala1Frank Chaky2Fabrizio Molteni3Ally Mohamed4Samwel Lazaro5Bushukatale Samwel6Bruno P. Mmbando7Department of Microbiology, Immunology, and Parasitology, Faculty of Medicine, Hubert Kairuki Memorial UniversityDepartment of Medical Parasitology and Entomology, Muhimbili University of Health and Allied SciencesNational Malaria Control Programme, Ministry of HealthSwiss Tropical and Public Health InstituteNational Malaria Control Programme, Ministry of HealthNational Malaria Control Programme, Ministry of HealthDepartment of Medical Parasitology and Entomology, Muhimbili University of Health and Allied SciencesNational Institute for Medical Research, Tanga Research CentreAbstract Effectiveness of dihydroartemisinin-piperaquine (DP) as seasonal malaria chemoprevention (SMC) was assessed in Nanyumbu and Masasi Districts. Between March and June 2021, children aged 3–59 months were enrolled in a cluster randomized study. Children in the intervention clusters received a monthly, 3-days course of DP for three consecutive months regardless of malaria infection status, and those in the control clusters received no intervention. Malaria infection was assessed at before the first-round and at 7 weeks after the third-round of DP in both arms. Malaria prevalence after the third-round of DP administration was the primary outcome. Chi-square tests and logistic regression model were used to compare proportions and adjust for explanatory variables. Before the intervention, malaria prevalence was 13.7% (161/1171) and 18.2% (212/1169) in the intervention and control clusters, respectively, p < 004. Malaria prevalence declined to 5.8% (60/1036) in the intervention clusters after three rounds of DP, and in the control clusters it declined to 9.3% (97/1048), p = 0.003. Unadjusted and adjusted prevalence ratios between the intervention and control arms were 0.42 (95%CI 0.32–0.55, p < 0.001) and 0.77 (95%CI 0.53–1.13, p = 0.189), respectively. SMC using DP was effective for control of malaria in the two Districts. Trial registration: NCT05874869, https://clinicaltrials.gov/ 25/05/2023.https://doi.org/10.1038/s41598-024-52706-z |
| spellingShingle | Richard Mwaiswelo Billy Ngasala Frank Chaky Fabrizio Molteni Ally Mohamed Samwel Lazaro Bushukatale Samwel Bruno P. Mmbando Dihydroartemisinin-piperaquine effectiveness for seasonal malaria chemoprevention in settings with extended seasonal malaria transmission in Tanzania Scientific Reports |
| title | Dihydroartemisinin-piperaquine effectiveness for seasonal malaria chemoprevention in settings with extended seasonal malaria transmission in Tanzania |
| title_full | Dihydroartemisinin-piperaquine effectiveness for seasonal malaria chemoprevention in settings with extended seasonal malaria transmission in Tanzania |
| title_fullStr | Dihydroartemisinin-piperaquine effectiveness for seasonal malaria chemoprevention in settings with extended seasonal malaria transmission in Tanzania |
| title_full_unstemmed | Dihydroartemisinin-piperaquine effectiveness for seasonal malaria chemoprevention in settings with extended seasonal malaria transmission in Tanzania |
| title_short | Dihydroartemisinin-piperaquine effectiveness for seasonal malaria chemoprevention in settings with extended seasonal malaria transmission in Tanzania |
| title_sort | dihydroartemisinin piperaquine effectiveness for seasonal malaria chemoprevention in settings with extended seasonal malaria transmission in tanzania |
| url | https://doi.org/10.1038/s41598-024-52706-z |
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