The Effect of Stress, Anxiety and Depression on In Vitro Fertilization Outcome in Kazakhstani Public Clinical Setting: A Cross-Sectional Study
Although it is clear that infertility leads to heightened stress for patients, the impact of depressed mood and anxiety on treatment outcome is inconsistently reported. The aim of this study was to evaluate the effect of stress, depression and anxiety on in vitro fertilization (IVF) outcomes in Kaza...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/5/937 |
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| author | Gauri Bapayeva Gulzhanat Aimagambetova Alpamys Issanov Sanja Terzic Talshyn Ukybassova Aidana Aldiyarova Gulnara Utepova Zhanibek Daribay Gulnara Bekbossinova Askhat Balykov Antonio Simone Laganà Milan Terzic |
| author_facet | Gauri Bapayeva Gulzhanat Aimagambetova Alpamys Issanov Sanja Terzic Talshyn Ukybassova Aidana Aldiyarova Gulnara Utepova Zhanibek Daribay Gulnara Bekbossinova Askhat Balykov Antonio Simone Laganà Milan Terzic |
| author_sort | Gauri Bapayeva |
| collection | DOAJ |
| description | Although it is clear that infertility leads to heightened stress for patients, the impact of depressed mood and anxiety on treatment outcome is inconsistently reported. The aim of this study was to evaluate the effect of stress, depression and anxiety on in vitro fertilization (IVF) outcomes in Kazakhstani public assisted reproductive technology (ART) clinics. The prospective cohort study was performed between June 2019 and September 2020 using questionnaires to assess psychological stress, depressed mood and anxiety in women referred to IVF clinics in two public clinical centers in Kazakhstan, Nur-Sultan and Aktobe. Our study sample comprised 142 women with the average age of 33.9 ± 4.9 years, and infertility duration 6.0 ± 3.5 years. More than half of respondents had Center for Epidemiological Studies Depression Scale (CES-D) scores higher than 16, indicating their risk of developing clinical depression. Ninety-one percent of women from Aktobe city were at risk for clinical depression (<i>p</i> < 0.001). Aktobe city respondents had higher stress subscale scores and anxiety scale scores (<i>p</i> < 0.001) than Nur-Sultan respondents. Statistical analysis showed that IVF outcome was not significantly associated with depression and stress, while the higher anxiety scale scores were negatively associated with clinical pregnancy after IVF. |
| first_indexed | 2024-03-09T06:08:57Z |
| format | Article |
| id | doaj.art-f55e7d97b4384ee3a6ef68934d2abc8b |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T06:08:57Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-f55e7d97b4384ee3a6ef68934d2abc8b2023-12-03T12:01:09ZengMDPI AGJournal of Clinical Medicine2077-03832021-03-0110593710.3390/jcm10050937The Effect of Stress, Anxiety and Depression on In Vitro Fertilization Outcome in Kazakhstani Public Clinical Setting: A Cross-Sectional StudyGauri Bapayeva0Gulzhanat Aimagambetova1Alpamys Issanov2Sanja Terzic3Talshyn Ukybassova4Aidana Aldiyarova5Gulnara Utepova6Zhanibek Daribay7Gulnara Bekbossinova8Askhat Balykov9Antonio Simone Laganà10Milan Terzic11Clinical Academic Department of Women’s Health, National Research Center of Mother and Child Health, University Medical Center, Nur-Sultan 010000, KazakhstanDepartment of Biomedical Sciences, Nazarbayev University School of Medicine, Nur-Sultan 010000, KazakhstanDepartment of Medicine, Nazarbayev University School of Medicine, Nur-Sultan 010000, KazakhstanDepartment of Medicine, Nazarbayev University School of Medicine, Nur-Sultan 010000, KazakhstanClinical Academic Department of Women’s Health, National Research Center of Mother and Child Health, University Medical Center, Nur-Sultan 010000, KazakhstanClinical Academic Department of Women’s Health, National Research Center of Mother and Child Health, University Medical Center, Nur-Sultan 010000, KazakhstanClinical Academic Department of Women’s Health, National Research Center of Mother and Child Health, University Medical Center, Nur-Sultan 010000, KazakhstanDepartment of Obstetrics and Gynecology #2, Marat Ospanov West Kazakhstan State Medical University, Aktobe 030000, KazakhstanRegional Perinatal Center, Aktobe 030000, KazakhstanRegional Perinatal Center, Aktobe 030000, KazakhstanDepartment of Obstetrics and Gynecology, “Filippo Del Ponte” Hospital, University of Insubria, 21100 Varese, ItalyClinical Academic Department of Women’s Health, National Research Center of Mother and Child Health, University Medical Center, Nur-Sultan 010000, KazakhstanAlthough it is clear that infertility leads to heightened stress for patients, the impact of depressed mood and anxiety on treatment outcome is inconsistently reported. The aim of this study was to evaluate the effect of stress, depression and anxiety on in vitro fertilization (IVF) outcomes in Kazakhstani public assisted reproductive technology (ART) clinics. The prospective cohort study was performed between June 2019 and September 2020 using questionnaires to assess psychological stress, depressed mood and anxiety in women referred to IVF clinics in two public clinical centers in Kazakhstan, Nur-Sultan and Aktobe. Our study sample comprised 142 women with the average age of 33.9 ± 4.9 years, and infertility duration 6.0 ± 3.5 years. More than half of respondents had Center for Epidemiological Studies Depression Scale (CES-D) scores higher than 16, indicating their risk of developing clinical depression. Ninety-one percent of women from Aktobe city were at risk for clinical depression (<i>p</i> < 0.001). Aktobe city respondents had higher stress subscale scores and anxiety scale scores (<i>p</i> < 0.001) than Nur-Sultan respondents. Statistical analysis showed that IVF outcome was not significantly associated with depression and stress, while the higher anxiety scale scores were negatively associated with clinical pregnancy after IVF.https://www.mdpi.com/2077-0383/10/5/937infertilityin vitro fertilizationstressdepressionanxietyKazakhstan |
| spellingShingle | Gauri Bapayeva Gulzhanat Aimagambetova Alpamys Issanov Sanja Terzic Talshyn Ukybassova Aidana Aldiyarova Gulnara Utepova Zhanibek Daribay Gulnara Bekbossinova Askhat Balykov Antonio Simone Laganà Milan Terzic The Effect of Stress, Anxiety and Depression on In Vitro Fertilization Outcome in Kazakhstani Public Clinical Setting: A Cross-Sectional Study Journal of Clinical Medicine infertility in vitro fertilization stress depression anxiety Kazakhstan |
| title | The Effect of Stress, Anxiety and Depression on In Vitro Fertilization Outcome in Kazakhstani Public Clinical Setting: A Cross-Sectional Study |
| title_full | The Effect of Stress, Anxiety and Depression on In Vitro Fertilization Outcome in Kazakhstani Public Clinical Setting: A Cross-Sectional Study |
| title_fullStr | The Effect of Stress, Anxiety and Depression on In Vitro Fertilization Outcome in Kazakhstani Public Clinical Setting: A Cross-Sectional Study |
| title_full_unstemmed | The Effect of Stress, Anxiety and Depression on In Vitro Fertilization Outcome in Kazakhstani Public Clinical Setting: A Cross-Sectional Study |
| title_short | The Effect of Stress, Anxiety and Depression on In Vitro Fertilization Outcome in Kazakhstani Public Clinical Setting: A Cross-Sectional Study |
| title_sort | effect of stress anxiety and depression on in vitro fertilization outcome in kazakhstani public clinical setting a cross sectional study |
| topic | infertility in vitro fertilization stress depression anxiety Kazakhstan |
| url | https://www.mdpi.com/2077-0383/10/5/937 |
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