The impact of diabetes mellitus on the emergence of multi-drug resistant tuberculosis and treatment failure in TB-diabetes comorbid patients: a systematic review and meta-analysis
BackgroundThe existence of Type 2 Diabetes Mellitus (DM) in tuberculosis (TB) patients is very dangerous for the health of patients. One of the major concerns is the emergence of MDR-TB in such patients. It is suspected that the development of MDR-TB further worsens the treatment outcomes of TB such...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1244450/full |
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| author | Anees ur Rehman Mahnoor Khattak Usman Mushtaq Muhammad Latif Imran Ahmad Muhammad Fawad Rasool Sadia Shakeel Khezar Hayat Rabia Hussain Ghaidaa Ali Alhazmi Afnan Owedah Alshomrani Mohammed Ibrahim Alalawi Saleh Alghamdi Mohammad Tarique Imam Safa S. Almarzoky Abuhussain Sarah M. Khayyat Abdul Haseeb |
| author_facet | Anees ur Rehman Mahnoor Khattak Usman Mushtaq Muhammad Latif Imran Ahmad Muhammad Fawad Rasool Sadia Shakeel Khezar Hayat Rabia Hussain Ghaidaa Ali Alhazmi Afnan Owedah Alshomrani Mohammed Ibrahim Alalawi Saleh Alghamdi Mohammad Tarique Imam Safa S. Almarzoky Abuhussain Sarah M. Khayyat Abdul Haseeb |
| author_sort | Anees ur Rehman |
| collection | DOAJ |
| description | BackgroundThe existence of Type 2 Diabetes Mellitus (DM) in tuberculosis (TB) patients is very dangerous for the health of patients. One of the major concerns is the emergence of MDR-TB in such patients. It is suspected that the development of MDR-TB further worsens the treatment outcomes of TB such as treatment failure and thus, causes disease progression.AimTo investigate the impact of DM on the Emergence of MDR-TB and Treatment Failure in TB-DM comorbid patients.MethodologyThe PubMed database was systematically searched until April 03, 2022 (date last searched). Thirty studies met the inclusion criteria and were included in this study after a proper selection process.ResultsTuberculosis-Diabetes Mellitus patients were at higher risk to develop MDR-TB as compared to TB-non-DM patients (HR 0.81, 95% CI: 0.60–0.96, p < 0.001). Heterogeneity observed among included studies was moderate (I2 = 38%). No significant change was observed in the results after sub-group analysis by study design (HR 0.81, 95% CI: 0.61–0.96, p < 0.000). In the case of treatment failure, TB-DM patients were at higher risk to experience treatment failure rates as compared to TB-non-DM patients (HR 0.46, 95% CI: 0.27–0.67, p < 0.001).ConclusionThe results showed that DM had a significant impact on the emergence of MDR-TB in TB-diabetes comorbid patients as compared to TB-non-DM patients. DM enhanced the risk of TB treatment failure rates in TB-diabetes patients as compared to TB-non-DM patients. Our study highlights the need for earlier screening of MDR-TB, thorough MDR-TB monitoring, and designing proper and effective treatment strategies to prevent disease progression. |
| first_indexed | 2024-03-09T23:53:07Z |
| format | Article |
| id | doaj.art-f560fdd8b51a40f28c8fe85bee2bfe52 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-03-09T23:53:07Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-f560fdd8b51a40f28c8fe85bee2bfe522023-11-23T16:31:44ZengFrontiers Media S.A.Frontiers in Public Health2296-25652023-11-011110.3389/fpubh.2023.12444501244450The impact of diabetes mellitus on the emergence of multi-drug resistant tuberculosis and treatment failure in TB-diabetes comorbid patients: a systematic review and meta-analysisAnees ur Rehman0Mahnoor Khattak1Usman Mushtaq2Muhammad Latif3Imran Ahmad4Muhammad Fawad Rasool5Sadia Shakeel6Khezar Hayat7Rabia Hussain8Ghaidaa Ali Alhazmi9Afnan Owedah Alshomrani10Mohammed Ibrahim Alalawi11Saleh Alghamdi12Mohammad Tarique Imam13Safa S. Almarzoky Abuhussain14Sarah M. Khayyat15Abdul Haseeb16Department of Pharmacy Practice, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, PakistanDepartment of Pharmacy Practice, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, PakistanNishter Medical University and Hospital, Multan, PakistanDepartment of Zoology, Division of Science and Technology, University of Education Lahore, Lahore, PakistanDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, PakistanDepartment of Pharmacy Practice, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, PakistanDepartment of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Dow University of Health Sciences, Karachi, PakistanInstitute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, PakistanSchool of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, MalaysiaDepartment of Pharmacy, King Abdullah Medical City, Ministry of Health, Makkah, Saudi ArabiaPharmaceutical Care Department, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Jeddah, Saudi Arabia0Internal Medicine Department, Alnoor Specialist Hospital, Makkah, Saudi Arabia1Department of Clinical Pharmacy, Faculty of Pharmacy, Al-Baha University, Al-Baha, Saudi Arabia2Department of Clinical Pharmacy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia3Department of Pharmacy Practice, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia3Department of Pharmacy Practice, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia3Department of Pharmacy Practice, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi ArabiaBackgroundThe existence of Type 2 Diabetes Mellitus (DM) in tuberculosis (TB) patients is very dangerous for the health of patients. One of the major concerns is the emergence of MDR-TB in such patients. It is suspected that the development of MDR-TB further worsens the treatment outcomes of TB such as treatment failure and thus, causes disease progression.AimTo investigate the impact of DM on the Emergence of MDR-TB and Treatment Failure in TB-DM comorbid patients.MethodologyThe PubMed database was systematically searched until April 03, 2022 (date last searched). Thirty studies met the inclusion criteria and were included in this study after a proper selection process.ResultsTuberculosis-Diabetes Mellitus patients were at higher risk to develop MDR-TB as compared to TB-non-DM patients (HR 0.81, 95% CI: 0.60–0.96, p < 0.001). Heterogeneity observed among included studies was moderate (I2 = 38%). No significant change was observed in the results after sub-group analysis by study design (HR 0.81, 95% CI: 0.61–0.96, p < 0.000). In the case of treatment failure, TB-DM patients were at higher risk to experience treatment failure rates as compared to TB-non-DM patients (HR 0.46, 95% CI: 0.27–0.67, p < 0.001).ConclusionThe results showed that DM had a significant impact on the emergence of MDR-TB in TB-diabetes comorbid patients as compared to TB-non-DM patients. DM enhanced the risk of TB treatment failure rates in TB-diabetes patients as compared to TB-non-DM patients. Our study highlights the need for earlier screening of MDR-TB, thorough MDR-TB monitoring, and designing proper and effective treatment strategies to prevent disease progression.https://www.frontiersin.org/articles/10.3389/fpubh.2023.1244450/fulltuberculosisdiabetes mellitusTB-DM comorbiditymulti-drug resistant TBtreatment failuredisease progression |
| spellingShingle | Anees ur Rehman Mahnoor Khattak Usman Mushtaq Muhammad Latif Imran Ahmad Muhammad Fawad Rasool Sadia Shakeel Khezar Hayat Rabia Hussain Ghaidaa Ali Alhazmi Afnan Owedah Alshomrani Mohammed Ibrahim Alalawi Saleh Alghamdi Mohammad Tarique Imam Safa S. Almarzoky Abuhussain Sarah M. Khayyat Abdul Haseeb The impact of diabetes mellitus on the emergence of multi-drug resistant tuberculosis and treatment failure in TB-diabetes comorbid patients: a systematic review and meta-analysis Frontiers in Public Health tuberculosis diabetes mellitus TB-DM comorbidity multi-drug resistant TB treatment failure disease progression |
| title | The impact of diabetes mellitus on the emergence of multi-drug resistant tuberculosis and treatment failure in TB-diabetes comorbid patients: a systematic review and meta-analysis |
| title_full | The impact of diabetes mellitus on the emergence of multi-drug resistant tuberculosis and treatment failure in TB-diabetes comorbid patients: a systematic review and meta-analysis |
| title_fullStr | The impact of diabetes mellitus on the emergence of multi-drug resistant tuberculosis and treatment failure in TB-diabetes comorbid patients: a systematic review and meta-analysis |
| title_full_unstemmed | The impact of diabetes mellitus on the emergence of multi-drug resistant tuberculosis and treatment failure in TB-diabetes comorbid patients: a systematic review and meta-analysis |
| title_short | The impact of diabetes mellitus on the emergence of multi-drug resistant tuberculosis and treatment failure in TB-diabetes comorbid patients: a systematic review and meta-analysis |
| title_sort | impact of diabetes mellitus on the emergence of multi drug resistant tuberculosis and treatment failure in tb diabetes comorbid patients a systematic review and meta analysis |
| topic | tuberculosis diabetes mellitus TB-DM comorbidity multi-drug resistant TB treatment failure disease progression |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1244450/full |
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