Extracorporeal Membrane Oxygenation with rituximab‐combined chemotherapy in AIDS‐associated primary cardiac lymphoma: A case report
Abstract Although effective combination of antiretroviral medications is being developed, the incidence of non‐Hodgkin lymphoma (NHL) with human immunodeficiency/acquired immunodeficiency syndrome (HIV/AIDS) still remains significantly higher than that in individuals without infection. Primary cardi...
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| Format: | Article |
| Language: | English |
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Wiley
2021-08-01
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| Series: | Clinical Case Reports |
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| Online Access: | https://doi.org/10.1002/ccr3.4704 |
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| author | Hoyuri Fuseya Takuro Yoshimura Minako Tsutsumi Yosuke Nakaya Mirei Horiuchi Masahiro Yoshida Yoshiki Hayashi Takafumi Nakao Takeshi Inoue Takahisa Yamane |
| author_facet | Hoyuri Fuseya Takuro Yoshimura Minako Tsutsumi Yosuke Nakaya Mirei Horiuchi Masahiro Yoshida Yoshiki Hayashi Takafumi Nakao Takeshi Inoue Takahisa Yamane |
| author_sort | Hoyuri Fuseya |
| collection | DOAJ |
| description | Abstract Although effective combination of antiretroviral medications is being developed, the incidence of non‐Hodgkin lymphoma (NHL) with human immunodeficiency/acquired immunodeficiency syndrome (HIV/AIDS) still remains significantly higher than that in individuals without infection. Primary cardiac lymphoma (PCL) is an NHL that involves the heart and/or the pericardium. PCL is very rare and often causes serious complications, which can be a diagnostic challenge. To our knowledge, no study has reported the measurement of rituximab concentration under venoarterial extracorporeal membrane oxygenation (VA‐ECMO). Herein, we report the case of a 54‐year‐old male patient with AIDS‐associated primary cardiac NHL who developed right ventricular outflow tract obstruction. The patient experienced fatigue and dyspnea on exertion. Contrast‐enhanced computed tomography showed a bulky tumor mass in his right atrium and ventricle, and an echocardiogram revealed severe hypokinesis of his heart and poor cardiac output. A biopsy was performed, and immunohistochemistry revealed diffuse large B‐cell lymphoma. Therefore, he was treated with rituximab‐combined chemotherapy under VA‐ECMO. Blood levels of rituximab were measured during chemotherapy with VA‐ECMO. Thereafter, he was temporarily discharged from the hospital. This clinical case suggests that VA‐ECMO and rituximab‐combined chemotherapy are useful in rescuing patients with severe cardiopulmonary failure due to AIDS‐associated PCL. |
| first_indexed | 2024-04-14T02:22:39Z |
| format | Article |
| id | doaj.art-f561c0abae78415d8875069d3ba5b34c |
| institution | Directory Open Access Journal |
| issn | 2050-0904 |
| language | English |
| last_indexed | 2024-04-14T02:22:39Z |
| publishDate | 2021-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj.art-f561c0abae78415d8875069d3ba5b34c2022-12-22T02:18:00ZengWileyClinical Case Reports2050-09042021-08-0198n/an/a10.1002/ccr3.4704Extracorporeal Membrane Oxygenation with rituximab‐combined chemotherapy in AIDS‐associated primary cardiac lymphoma: A case reportHoyuri Fuseya0Takuro Yoshimura1Minako Tsutsumi2Yosuke Nakaya3Mirei Horiuchi4Masahiro Yoshida5Yoshiki Hayashi6Takafumi Nakao7Takeshi Inoue8Takahisa Yamane9Department of Hematology Osaka City General Hospital Osaka JapanDepartment of Hematology Osaka City General Hospital Osaka JapanDepartment of Hematology Osaka City General Hospital Osaka JapanDepartment of Hematology Osaka City General Hospital Osaka JapanDepartment of Hematology Osaka City General Hospital Osaka JapanDepartment of Hematology Osaka City General Hospital Osaka JapanDepartment of Hematology Osaka City General Hospital Osaka JapanDepartment of Hematology Osaka City General Hospital Osaka JapanDepartment of Pathology Osaka City General Hospital Osaka JapanDepartment of Hematology Osaka City General Hospital Osaka JapanAbstract Although effective combination of antiretroviral medications is being developed, the incidence of non‐Hodgkin lymphoma (NHL) with human immunodeficiency/acquired immunodeficiency syndrome (HIV/AIDS) still remains significantly higher than that in individuals without infection. Primary cardiac lymphoma (PCL) is an NHL that involves the heart and/or the pericardium. PCL is very rare and often causes serious complications, which can be a diagnostic challenge. To our knowledge, no study has reported the measurement of rituximab concentration under venoarterial extracorporeal membrane oxygenation (VA‐ECMO). Herein, we report the case of a 54‐year‐old male patient with AIDS‐associated primary cardiac NHL who developed right ventricular outflow tract obstruction. The patient experienced fatigue and dyspnea on exertion. Contrast‐enhanced computed tomography showed a bulky tumor mass in his right atrium and ventricle, and an echocardiogram revealed severe hypokinesis of his heart and poor cardiac output. A biopsy was performed, and immunohistochemistry revealed diffuse large B‐cell lymphoma. Therefore, he was treated with rituximab‐combined chemotherapy under VA‐ECMO. Blood levels of rituximab were measured during chemotherapy with VA‐ECMO. Thereafter, he was temporarily discharged from the hospital. This clinical case suggests that VA‐ECMO and rituximab‐combined chemotherapy are useful in rescuing patients with severe cardiopulmonary failure due to AIDS‐associated PCL.https://doi.org/10.1002/ccr3.4704acquired immune deficiency syndrome (AIDS)diffuse large B‐cell lymphoma (DLBCL)extracorporeal membrane oxygenation (ECMO)primary cardiac lymphoma (PCL)rituximab |
| spellingShingle | Hoyuri Fuseya Takuro Yoshimura Minako Tsutsumi Yosuke Nakaya Mirei Horiuchi Masahiro Yoshida Yoshiki Hayashi Takafumi Nakao Takeshi Inoue Takahisa Yamane Extracorporeal Membrane Oxygenation with rituximab‐combined chemotherapy in AIDS‐associated primary cardiac lymphoma: A case report Clinical Case Reports acquired immune deficiency syndrome (AIDS) diffuse large B‐cell lymphoma (DLBCL) extracorporeal membrane oxygenation (ECMO) primary cardiac lymphoma (PCL) rituximab |
| title | Extracorporeal Membrane Oxygenation with rituximab‐combined chemotherapy in AIDS‐associated primary cardiac lymphoma: A case report |
| title_full | Extracorporeal Membrane Oxygenation with rituximab‐combined chemotherapy in AIDS‐associated primary cardiac lymphoma: A case report |
| title_fullStr | Extracorporeal Membrane Oxygenation with rituximab‐combined chemotherapy in AIDS‐associated primary cardiac lymphoma: A case report |
| title_full_unstemmed | Extracorporeal Membrane Oxygenation with rituximab‐combined chemotherapy in AIDS‐associated primary cardiac lymphoma: A case report |
| title_short | Extracorporeal Membrane Oxygenation with rituximab‐combined chemotherapy in AIDS‐associated primary cardiac lymphoma: A case report |
| title_sort | extracorporeal membrane oxygenation with rituximab combined chemotherapy in aids associated primary cardiac lymphoma a case report |
| topic | acquired immune deficiency syndrome (AIDS) diffuse large B‐cell lymphoma (DLBCL) extracorporeal membrane oxygenation (ECMO) primary cardiac lymphoma (PCL) rituximab |
| url | https://doi.org/10.1002/ccr3.4704 |
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