Identification of a novel cytosolic aldehyde dehydrogenase allele, <it>ALDHIAI*4</it>

Identification of a novel cytosolic aldehyde dehydrogenase allele, <it>ALDHIAI*4</it>

<p>Abstract</p> <p>This paper reports the identification of a novel cytosolic aldehyde dehydrogenase 1 (<it>ALDHIAI</it>) allele. One hundred and sixty-two Indo-Trinidadian and 85 Afro-Trinidadian individuals were genotyped. A novel <it>ALDHIAI </it>allele,...

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Bibliographic Details
Main Authors: Moore Shelley M, Liang Tiebing, Graves Tamara J, McCall Kevin M, Carr Lucinda G, Ehlers Cindy L
Format: Article
Language:English
Published: BMC 2009-07-01
Series:Human Genomics
Subjects:
ALDHIAI
base pair
polymorphism
Trinidad and Tobago
Online Access:http://www.humgenomics.com/content/3/4/304
Description
Summary:<p>Abstract</p> <p>This paper reports the identification of a novel cytosolic aldehyde dehydrogenase 1 (<it>ALDHIAI</it>) allele. One hundred and sixty-two Indo-Trinidadian and 85 Afro-Trinidadian individuals were genotyped. A novel <it>ALDHIAI </it>allele, <it>ALDHIAI*4</it>, was identified in an Indo-Trinidadian alcoholic with an A inserted at position -554 relative to the translational start site, +1. It was concluded that a wider cross-section of individuals needs to be evaluated in order to determine the representative frequency of the allele, and to see if it is associated with risk of alcoholism.</p>
ISSN:1479-7364

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