Alterations in One-Carbon Metabolism in Celiac Disease
Celiac disease (CD) is an autoimmune enteropathy associated with alterations of metabolism. Metabolomics studies, although limited, showed changes in choline, choline-derived lipids, and methionine concentrations, which could be ascribed to alterations in one-carbon metabolism. To date, no targeted...
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| Format: | Article |
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MDPI AG
2020-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/12/3723 |
| _version_ | 1797545994457448448 |
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| author | Rafael Martín-Masot Natàlia Mota-Martorell Mariona Jové José Maldonado Reinald Pamplona Teresa Nestares |
| author_facet | Rafael Martín-Masot Natàlia Mota-Martorell Mariona Jové José Maldonado Reinald Pamplona Teresa Nestares |
| author_sort | Rafael Martín-Masot |
| collection | DOAJ |
| description | Celiac disease (CD) is an autoimmune enteropathy associated with alterations of metabolism. Metabolomics studies, although limited, showed changes in choline, choline-derived lipids, and methionine concentrations, which could be ascribed to alterations in one-carbon metabolism. To date, no targeted metabolomics analysis investigating differences in the plasma choline/methionine metabolome of CD subjects are reported. This work is a targeted metabolomic study that analyzes 37 metabolites of the one-carbon metabolism in 17 children with CD, treated with a gluten-free diet and 17 healthy control siblings, in order to establish the potential defects in this metabolic network. Our results demonstrate the persistence of defects in the transsulfuration pathway of CD subjects, despite dietary treatment, while choline metabolism, methionine cycle, and folate cycle seem to be reversed and preserved to healthy levels. These findings describe for the first time, a metabolic defect in one-carbon metabolism which could have profound implications in the physiopathology and treatment of CD. |
| first_indexed | 2024-03-10T14:22:51Z |
| format | Article |
| id | doaj.art-f564e4e2cde348d8afd612e63baa6c36 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T14:22:51Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-f564e4e2cde348d8afd612e63baa6c362023-11-20T23:14:58ZengMDPI AGNutrients2072-66432020-12-011212372310.3390/nu12123723Alterations in One-Carbon Metabolism in Celiac DiseaseRafael Martín-Masot0Natàlia Mota-Martorell1Mariona Jové2José Maldonado3Reinald Pamplona4Teresa Nestares5Pediatric Gastroenterology and Nutrition Unit, Hospital Regional Universitario de Málaga, 29011 Malaga, SpainDepartment of Experimental Medicine, Lleida Biomedical Research Institute (IRBLleida), University of Lleida (UdL), 25198 Lleida, SpainDepartment of Experimental Medicine, Lleida Biomedical Research Institute (IRBLleida), University of Lleida (UdL), 25198 Lleida, SpainDepartment of Pediatrics, University of Granada, 18071 Granada, SpainDepartment of Experimental Medicine, Lleida Biomedical Research Institute (IRBLleida), University of Lleida (UdL), 25198 Lleida, SpainBiomedical Research Centre (CIBM), Department of Physiology and “José MataixVerdú” Institute of Nutrition and Food Technology (INYTA), University of Granada, 18071 Granada, SpainCeliac disease (CD) is an autoimmune enteropathy associated with alterations of metabolism. Metabolomics studies, although limited, showed changes in choline, choline-derived lipids, and methionine concentrations, which could be ascribed to alterations in one-carbon metabolism. To date, no targeted metabolomics analysis investigating differences in the plasma choline/methionine metabolome of CD subjects are reported. This work is a targeted metabolomic study that analyzes 37 metabolites of the one-carbon metabolism in 17 children with CD, treated with a gluten-free diet and 17 healthy control siblings, in order to establish the potential defects in this metabolic network. Our results demonstrate the persistence of defects in the transsulfuration pathway of CD subjects, despite dietary treatment, while choline metabolism, methionine cycle, and folate cycle seem to be reversed and preserved to healthy levels. These findings describe for the first time, a metabolic defect in one-carbon metabolism which could have profound implications in the physiopathology and treatment of CD.https://www.mdpi.com/2072-6643/12/12/3723amino acidscholineceliac diseasefolate cyclemass spectrometrymethionine cycle |
| spellingShingle | Rafael Martín-Masot Natàlia Mota-Martorell Mariona Jové José Maldonado Reinald Pamplona Teresa Nestares Alterations in One-Carbon Metabolism in Celiac Disease Nutrients amino acids choline celiac disease folate cycle mass spectrometry methionine cycle |
| title | Alterations in One-Carbon Metabolism in Celiac Disease |
| title_full | Alterations in One-Carbon Metabolism in Celiac Disease |
| title_fullStr | Alterations in One-Carbon Metabolism in Celiac Disease |
| title_full_unstemmed | Alterations in One-Carbon Metabolism in Celiac Disease |
| title_short | Alterations in One-Carbon Metabolism in Celiac Disease |
| title_sort | alterations in one carbon metabolism in celiac disease |
| topic | amino acids choline celiac disease folate cycle mass spectrometry methionine cycle |
| url | https://www.mdpi.com/2072-6643/12/12/3723 |
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