<i>Gelsemium elegans</i> Benth: Chemical Components, Pharmacological Effects, and Toxicity Mechanisms
<i>Gelsemium elegans</i> Benth (GEB), also known as heartbreak grass, is a highly poisonous plant belonging to the family <i>Loganiaceae</i> and genus <i>Gelsemium</i> that has broad application prospects in medicine. This article reviews its chemical components,...
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| Format: | Article |
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MDPI AG
2021-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/23/7145 |
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| author | Hailing Lin Hongqiang Qiu Yu Cheng Maobai Liu Maohua Chen Youxiong Que Wancai Que |
| author_facet | Hailing Lin Hongqiang Qiu Yu Cheng Maobai Liu Maohua Chen Youxiong Que Wancai Que |
| author_sort | Hailing Lin |
| collection | DOAJ |
| description | <i>Gelsemium elegans</i> Benth (GEB), also known as heartbreak grass, is a highly poisonous plant belonging to the family <i>Loganiaceae</i> and genus <i>Gelsemium</i> that has broad application prospects in medicine. This article reviews its chemical components, pharmacological effects, toxicity mechanisms, and research progress in clinical applications in recent years. Indole alkaloids are the main active components of GEB and have a variety of pharmacological and biological functions. They have anti-tumor, anti-inflammatory, analgesic, and immunomodulation properties, with the therapeutic dose being close to the toxic dose. Application of small-dose indole alkaloids fails to work effectively, while high-dose usage is prone to poisoning, aggravating the patient’s conditions. Special caution is needed, especially to observe the changes in the disease condition of the patients in clinical practice. In-depth research on the chemical components and mechanisms of GEB is essential to the development of promising lead compounds and lays the foundation for extensive clinical application and safe usage of GEB in the future. |
| first_indexed | 2024-03-10T04:48:55Z |
| format | Article |
| id | doaj.art-f565d58e655b4b41b1c65c6bc38b06c8 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T04:48:55Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-f565d58e655b4b41b1c65c6bc38b06c82023-11-23T02:48:04ZengMDPI AGMolecules1420-30492021-11-012623714510.3390/molecules26237145<i>Gelsemium elegans</i> Benth: Chemical Components, Pharmacological Effects, and Toxicity MechanismsHailing Lin0Hongqiang Qiu1Yu Cheng2Maobai Liu3Maohua Chen4Youxiong Que5Wancai Que6Department of Pharmacy, Fujian Medical University Union Hospital, 29 Xin Quan Rd, Gulou, Fuzhou 350001, ChinaDepartment of Pharmacy, Fujian Medical University Union Hospital, 29 Xin Quan Rd, Gulou, Fuzhou 350001, ChinaDepartment of Pharmacy, Fujian Medical University Union Hospital, 29 Xin Quan Rd, Gulou, Fuzhou 350001, ChinaDepartment of Pharmacy, Fujian Medical University Union Hospital, 29 Xin Quan Rd, Gulou, Fuzhou 350001, ChinaDepartment of Pharmacy, Fujian Medical University Union Hospital, 29 Xin Quan Rd, Gulou, Fuzhou 350001, ChinaCollege of Agriculture, Fujian Agriculture and Forestry University, Fuzhou 350002, ChinaDepartment of Pharmacy, Fujian Medical University Union Hospital, 29 Xin Quan Rd, Gulou, Fuzhou 350001, China<i>Gelsemium elegans</i> Benth (GEB), also known as heartbreak grass, is a highly poisonous plant belonging to the family <i>Loganiaceae</i> and genus <i>Gelsemium</i> that has broad application prospects in medicine. This article reviews its chemical components, pharmacological effects, toxicity mechanisms, and research progress in clinical applications in recent years. Indole alkaloids are the main active components of GEB and have a variety of pharmacological and biological functions. They have anti-tumor, anti-inflammatory, analgesic, and immunomodulation properties, with the therapeutic dose being close to the toxic dose. Application of small-dose indole alkaloids fails to work effectively, while high-dose usage is prone to poisoning, aggravating the patient’s conditions. Special caution is needed, especially to observe the changes in the disease condition of the patients in clinical practice. In-depth research on the chemical components and mechanisms of GEB is essential to the development of promising lead compounds and lays the foundation for extensive clinical application and safe usage of GEB in the future.https://www.mdpi.com/1420-3049/26/23/7145<i>Gelsemium elegans</i> Benth (GEB)pharmacologytoxicologymechanisms |
| spellingShingle | Hailing Lin Hongqiang Qiu Yu Cheng Maobai Liu Maohua Chen Youxiong Que Wancai Que <i>Gelsemium elegans</i> Benth: Chemical Components, Pharmacological Effects, and Toxicity Mechanisms Molecules <i>Gelsemium elegans</i> Benth (GEB) pharmacology toxicology mechanisms |
| title | <i>Gelsemium elegans</i> Benth: Chemical Components, Pharmacological Effects, and Toxicity Mechanisms |
| title_full | <i>Gelsemium elegans</i> Benth: Chemical Components, Pharmacological Effects, and Toxicity Mechanisms |
| title_fullStr | <i>Gelsemium elegans</i> Benth: Chemical Components, Pharmacological Effects, and Toxicity Mechanisms |
| title_full_unstemmed | <i>Gelsemium elegans</i> Benth: Chemical Components, Pharmacological Effects, and Toxicity Mechanisms |
| title_short | <i>Gelsemium elegans</i> Benth: Chemical Components, Pharmacological Effects, and Toxicity Mechanisms |
| title_sort | i gelsemium elegans i benth chemical components pharmacological effects and toxicity mechanisms |
| topic | <i>Gelsemium elegans</i> Benth (GEB) pharmacology toxicology mechanisms |
| url | https://www.mdpi.com/1420-3049/26/23/7145 |
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