Intraoral Myeloid Sarcoma with Bilateral Involvement - Case Report
Background: Myeloid sarcoma (MS) is a solid malignant tumour associated with infiltration of immature myeloid precursor cells in an extramedullary site. The term MS has replaced the term granulocytic sarcoma and chloroma, which were used in the past. MS in the oral cavity is very uncommon, with less...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Balkan Stomatological Society
2017-07-01
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| Series: | Balkan Journal of Dental Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/bjdm-2017-0020 |
| _version_ | 1828544540482469888 |
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| author | Poulopoulos Athanasios Iordanidis Fotios Andreadis Dimitrios Antoniadis Konstantinos |
| author_facet | Poulopoulos Athanasios Iordanidis Fotios Andreadis Dimitrios Antoniadis Konstantinos |
| author_sort | Poulopoulos Athanasios |
| collection | DOAJ |
| description | Background: Myeloid sarcoma (MS) is a solid malignant tumour associated with infiltration of immature myeloid precursor cells in an extramedullary site. The term MS has replaced the term granulocytic sarcoma and chloroma, which were used in the past. MS in the oral cavity is very uncommon, with less of 40 cases reported until recently. Case Report: We report the first case, the features, and the diagnostic sequence, of intraoral MS with bilateral palatal involvement, which presented as an initial manifestation, and preceded the appearance of acute myeloid leukaemia (AML). Diagnostic confirmation of such oral mucosal lesions usually requires biopsy, histopathological examination with additional immunohistochemical investigation. MS can occur during the course of acute or chronic myelogenous leukaemia, and myelodysplastic syndromes. In the vast majority of the reported cases, only one site was involved with a single intraoral MS lesion, and the cases predominantly associated with AML. Conclusion: The majority of intraoral MS occurs in patients with known AML, but in some of them, presented as an initial manifestation, and preceded the appearance of the disease. Therefore, clinicians should carefully evaluate all unusual oral lesions of unknown origin. |
| first_indexed | 2024-12-12T02:32:28Z |
| format | Article |
| id | doaj.art-f567d090b7b343f597d3ec38676e1b0e |
| institution | Directory Open Access Journal |
| issn | 2335-0245 |
| language | English |
| last_indexed | 2024-12-12T02:32:28Z |
| publishDate | 2017-07-01 |
| publisher | Balkan Stomatological Society |
| record_format | Article |
| series | Balkan Journal of Dental Medicine |
| spelling | doaj.art-f567d090b7b343f597d3ec38676e1b0e2022-12-22T00:41:22ZengBalkan Stomatological SocietyBalkan Journal of Dental Medicine2335-02452017-07-0121211912210.1515/bjdm-2017-0020bjdm-2017-0020Intraoral Myeloid Sarcoma with Bilateral Involvement - Case ReportPoulopoulos Athanasios0Iordanidis Fotios1Andreadis Dimitrios2Antoniadis Konstantinos3Department of Oral Medicine & Oral Pathology, Dental School, Aristotle University of Thessaloniki, Thessaloniki, GreeceGloucestershire Cellular Pathology Laboratory, Cheltenham General Hospital, Cheltenham, United Kingdom of Great Britain and Northern IrelandDepartment of Oral Medicine & Oral Pathology, Dental School, Aristotle University of Thessaloniki, Thessaloniki, GreeceDepartment of Oral & Maxillofacial Surgery Dental School, Aristotle University of Thessaloniki, Thessaloniki, GreeceBackground: Myeloid sarcoma (MS) is a solid malignant tumour associated with infiltration of immature myeloid precursor cells in an extramedullary site. The term MS has replaced the term granulocytic sarcoma and chloroma, which were used in the past. MS in the oral cavity is very uncommon, with less of 40 cases reported until recently. Case Report: We report the first case, the features, and the diagnostic sequence, of intraoral MS with bilateral palatal involvement, which presented as an initial manifestation, and preceded the appearance of acute myeloid leukaemia (AML). Diagnostic confirmation of such oral mucosal lesions usually requires biopsy, histopathological examination with additional immunohistochemical investigation. MS can occur during the course of acute or chronic myelogenous leukaemia, and myelodysplastic syndromes. In the vast majority of the reported cases, only one site was involved with a single intraoral MS lesion, and the cases predominantly associated with AML. Conclusion: The majority of intraoral MS occurs in patients with known AML, but in some of them, presented as an initial manifestation, and preceded the appearance of the disease. Therefore, clinicians should carefully evaluate all unusual oral lesions of unknown origin.https://doi.org/10.1515/bjdm-2017-0020myeloid sarcomagranulocytic sarcomachloromaacute myeloid leukaemiaoral tumours |
| spellingShingle | Poulopoulos Athanasios Iordanidis Fotios Andreadis Dimitrios Antoniadis Konstantinos Intraoral Myeloid Sarcoma with Bilateral Involvement - Case Report Balkan Journal of Dental Medicine myeloid sarcoma granulocytic sarcoma chloroma acute myeloid leukaemia oral tumours |
| title | Intraoral Myeloid Sarcoma with Bilateral Involvement - Case Report |
| title_full | Intraoral Myeloid Sarcoma with Bilateral Involvement - Case Report |
| title_fullStr | Intraoral Myeloid Sarcoma with Bilateral Involvement - Case Report |
| title_full_unstemmed | Intraoral Myeloid Sarcoma with Bilateral Involvement - Case Report |
| title_short | Intraoral Myeloid Sarcoma with Bilateral Involvement - Case Report |
| title_sort | intraoral myeloid sarcoma with bilateral involvement case report |
| topic | myeloid sarcoma granulocytic sarcoma chloroma acute myeloid leukaemia oral tumours |
| url | https://doi.org/10.1515/bjdm-2017-0020 |
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