The challenge of musculoskeletal tissue engineering – from cell cultures to large animal models

The challenge of musculoskeletal tissue engineering – from cell cultures to large animal models

Engineering functional skeletal muscle tissue still remains a major challenge. So far clinically relevant sizes of functional skeletal muscle tissue could not be engineered yet. One of the obstacles to overcome is the development of a suitable scaffold for muscle tissue engineering in vivo, another...

Full description

Bibliographic Details
Main Authors: Beier, Justus P., Boos, Anja M., Weigand, Annika, Arkudas, Andreas, Horch, Raymund E.
Format: Article
Language:deu
Published: German Medical Science GMS Publishing House 2015-08-01
Series:GMS German Plastic, Reconstructive and Aesthetic Surgery – Burn and Hand Surgery
Subjects:
skeletal muscle tissue engineering
axial vascularization
electrospun nanofibers
myoblasts
mesenchymal stem cells
large animal model
Online Access:http://www.egms.de/static/en/journals/gpras/2015-5/gpras000033.shtml
Description
Summary:Engineering functional skeletal muscle tissue still remains a major challenge. So far clinically relevant sizes of functional skeletal muscle tissue could not be engineered yet. One of the obstacles to overcome is the development of a suitable scaffold for muscle tissue engineering in vivo, another is the lack of differentiation in expanded adult muscle precursor cells. Materials and different architectures of scaffolds which are used for engineering functional skeletal muscle are presented here as well as approaches to the differentiation challenge. Finally the translation from cell culture over small to large animal models for engineering axially vascularized musculoskeletal tissues will be described.
ISSN:2193-7052

Similar Items