Development and Evaluation of a Reconstitutable Dry Suspension to Improve the Dissolution and Oral Absorption of Poorly Water-Soluble Celecoxib

Development and Evaluation of a Reconstitutable Dry Suspension to Improve the Dissolution and Oral Absorption of Poorly Water-Soluble Celecoxib

This study aims at developing and evaluating reconstitutable dry suspension (RDS) improved for dissolution rate, oral absorption, and convenience of use of poorly water-soluble celecoxib (CXB). Micro-sized CXB particle was used to manufacture nanosuspension by using bead milling and then RDS was mad...

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Bibliographic Details
Main Authors: Hye-In Kim, Sang Yeob Park, Seok Ju Park, Jewon Lee, Kwan Hyung Cho, Jun-Pil Jee, Hee-Cheol Kim, Han-Joo Maeng, Dong-Jin Jang
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Pharmaceutics
Subjects:
reconstitutable
nanosuspension
bead milling
crystallinity
dissolution
pharmacokinetics
Online Access:http://www.mdpi.com/1999-4923/10/3/140

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