Investigating the novel-binding site of RPA2 on Menin and predicting the effect of point mutation of Menin through protein–protein interactions

Investigating the novel-binding site of RPA2 on Menin and predicting the effect of point mutation of Menin through protein–protein interactions

Abstract Protein–protein interactions (PPIs) play a critical role in all biological processes. Menin is tumor suppressor protein, mutated in multiple endocrine neoplasia type 1 syndrome and has been shown to interact with multiple transcription factors including (RPA2) subunit of replication protein...

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Bibliographic Details
Main Authors: Gurjeet Kaur, Manisha Prajapat, Harvinder Singh, Phulen sarma, Sanjay kumar Bhadada, Nishant Shekhar, Saurabh Sharma, Shweta Sinha, Subodh kumar, Ajay Prakash, Bikash Medhi
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-35599-2

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