Mitochondrial heterogeneity in diseases
Abstract As key organelles involved in cellular metabolism, mitochondria frequently undergo adaptive changes in morphology, components and functions in response to various environmental stresses and cellular demands. Previous studies of mitochondria research have gradually evolved, from focusing on...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-08-01
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| Series: | Signal Transduction and Targeted Therapy |
| Online Access: | https://doi.org/10.1038/s41392-023-01546-w |
| _version_ | 1797556131624648704 |
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| author | Long Chen Mengnan Zhou Hao Li Delin Liu Peng Liao Yao Zong Changqing Zhang Weiguo Zou Junjie Gao |
| author_facet | Long Chen Mengnan Zhou Hao Li Delin Liu Peng Liao Yao Zong Changqing Zhang Weiguo Zou Junjie Gao |
| author_sort | Long Chen |
| collection | DOAJ |
| description | Abstract As key organelles involved in cellular metabolism, mitochondria frequently undergo adaptive changes in morphology, components and functions in response to various environmental stresses and cellular demands. Previous studies of mitochondria research have gradually evolved, from focusing on morphological change analysis to systematic multiomics, thereby revealing the mitochondrial variation between cells or within the mitochondrial population within a single cell. The phenomenon of mitochondrial variation features is defined as mitochondrial heterogeneity. Moreover, mitochondrial heterogeneity has been reported to influence a variety of physiological processes, including tissue homeostasis, tissue repair, immunoregulation, and tumor progression. Here, we comprehensively review the mitochondrial heterogeneity in different tissues under pathological states, involving variant features of mitochondrial DNA, RNA, protein and lipid components. Then, the mechanisms that contribute to mitochondrial heterogeneity are also summarized, such as the mutation of the mitochondrial genome and the import of mitochondrial proteins that result in the heterogeneity of mitochondrial DNA and protein components. Additionally, multiple perspectives are investigated to better comprehend the mysteries of mitochondrial heterogeneity between cells. Finally, we summarize the prospective mitochondrial heterogeneity-targeting therapies in terms of alleviating mitochondrial oxidative damage, reducing mitochondrial carbon stress and enhancing mitochondrial biogenesis to relieve various pathological conditions. The possibility of recent technological advances in targeted mitochondrial gene editing is also discussed. |
| first_indexed | 2024-03-10T16:58:30Z |
| format | Article |
| id | doaj.art-f56d46dc305b42998fe8519b7a9ed41e |
| institution | Directory Open Access Journal |
| issn | 2059-3635 |
| language | English |
| last_indexed | 2024-03-10T16:58:30Z |
| publishDate | 2023-08-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Signal Transduction and Targeted Therapy |
| spelling | doaj.art-f56d46dc305b42998fe8519b7a9ed41e2023-11-20T11:04:53ZengNature Publishing GroupSignal Transduction and Targeted Therapy2059-36352023-08-018112710.1038/s41392-023-01546-wMitochondrial heterogeneity in diseasesLong Chen0Mengnan Zhou1Hao Li2Delin Liu3Peng Liao4Yao Zong5Changqing Zhang6Weiguo Zou7Junjie Gao8State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Sciences, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of SciencesDepartment of Pathogenic Biology, School of Basic Medical Science, China Medical UniversityDepartment of Orthopaedics, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Orthopaedics, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Orthopaedics, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineCentre for Orthopaedic Research, Medical School, The University of Western AustraliaDepartment of Orthopaedics, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineState Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Sciences, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of SciencesDepartment of Orthopaedics, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineAbstract As key organelles involved in cellular metabolism, mitochondria frequently undergo adaptive changes in morphology, components and functions in response to various environmental stresses and cellular demands. Previous studies of mitochondria research have gradually evolved, from focusing on morphological change analysis to systematic multiomics, thereby revealing the mitochondrial variation between cells or within the mitochondrial population within a single cell. The phenomenon of mitochondrial variation features is defined as mitochondrial heterogeneity. Moreover, mitochondrial heterogeneity has been reported to influence a variety of physiological processes, including tissue homeostasis, tissue repair, immunoregulation, and tumor progression. Here, we comprehensively review the mitochondrial heterogeneity in different tissues under pathological states, involving variant features of mitochondrial DNA, RNA, protein and lipid components. Then, the mechanisms that contribute to mitochondrial heterogeneity are also summarized, such as the mutation of the mitochondrial genome and the import of mitochondrial proteins that result in the heterogeneity of mitochondrial DNA and protein components. Additionally, multiple perspectives are investigated to better comprehend the mysteries of mitochondrial heterogeneity between cells. Finally, we summarize the prospective mitochondrial heterogeneity-targeting therapies in terms of alleviating mitochondrial oxidative damage, reducing mitochondrial carbon stress and enhancing mitochondrial biogenesis to relieve various pathological conditions. The possibility of recent technological advances in targeted mitochondrial gene editing is also discussed.https://doi.org/10.1038/s41392-023-01546-w |
| spellingShingle | Long Chen Mengnan Zhou Hao Li Delin Liu Peng Liao Yao Zong Changqing Zhang Weiguo Zou Junjie Gao Mitochondrial heterogeneity in diseases Signal Transduction and Targeted Therapy |
| title | Mitochondrial heterogeneity in diseases |
| title_full | Mitochondrial heterogeneity in diseases |
| title_fullStr | Mitochondrial heterogeneity in diseases |
| title_full_unstemmed | Mitochondrial heterogeneity in diseases |
| title_short | Mitochondrial heterogeneity in diseases |
| title_sort | mitochondrial heterogeneity in diseases |
| url | https://doi.org/10.1038/s41392-023-01546-w |
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