Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer.
<h4>Objective</h4>The rare incidence of submucosal invasive non-ampullary duodenal carcinoma has led to scant information in literature; therefore, we compared the clinicopathological features between submucosal invasive carcinoma (SM-Ca), mucosal carcinoma (M-Ca), and advanced carcinoma...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0256797 |
| _version_ | 1818363135450415104 |
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| author | Katsunori Matsueda Hiromitsu Kanzaki Ryuta Takenaka Masahiro Nakagawa Kazuhiro Matsueda Masaya Iwamuro Seiji Kawano Yoshiro Kawahara Tomohiro Toji Takehiro Tanaka Takahito Yagi Toshiyoshi Fujiwara Hiroyuki Okada |
| author_facet | Katsunori Matsueda Hiromitsu Kanzaki Ryuta Takenaka Masahiro Nakagawa Kazuhiro Matsueda Masaya Iwamuro Seiji Kawano Yoshiro Kawahara Tomohiro Toji Takehiro Tanaka Takahito Yagi Toshiyoshi Fujiwara Hiroyuki Okada |
| author_sort | Katsunori Matsueda |
| collection | DOAJ |
| description | <h4>Objective</h4>The rare incidence of submucosal invasive non-ampullary duodenal carcinoma has led to scant information in literature; therefore, we compared the clinicopathological features between submucosal invasive carcinoma (SM-Ca), mucosal carcinoma (M-Ca), and advanced carcinoma (Ad-Ca).<h4>Materials</h4>We retrospectively analyzed 165 patients with sporadic non-ampullary duodenal carcinomas (SNADCs) from four institutions between January 2003 and December 2018. The SNADCs were divided to three groups according to histological diagnosis: SM-Ca, M-Ca, and Ad-Ca. The clinicopathological characteristics and mucin phenotypes were compared between groups.<h4>Results</h4>Among the 165 SNADCs, 11 (7%) were classified as SM-Ca, 70 (42%) as M-Ca, and 84 (51%) as Ad-Ca. We found that all SM-Ca (P = 0.013) and most Ad-Ca (P = 0.020) lesions were located on the oral-Vater; however, an almost equal distribution of M-Ca lesions was found between the oral- and anal-Vater. No significant difference was observed between the tumor diameter of M-Ca and SM-Ca; however, 45% (5/11) of SM-Ca were ≤10 mm. A total of 73% (8/11) of SM-Ca were classified as gastric phenotype and no lesions were classified as intestinal phenotype; whereas most M-Ca were classified as intestinal phenotype (67%, 8/12).<h4>Conclusions</h4>SM-Ca lesions were all located on the oral-Vater and were highly associated with the gastric mucin phenotype, which were different from the features of most M-Ca. |
| first_indexed | 2024-12-13T21:43:40Z |
| format | Article |
| id | doaj.art-f56dc1d9a0b44cb88ca59770a5b0a6ff |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T21:43:40Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f56dc1d9a0b44cb88ca59770a5b0a6ff2022-12-21T23:30:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01168e025679710.1371/journal.pone.0256797Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer.Katsunori MatsuedaHiromitsu KanzakiRyuta TakenakaMasahiro NakagawaKazuhiro MatsuedaMasaya IwamuroSeiji KawanoYoshiro KawaharaTomohiro TojiTakehiro TanakaTakahito YagiToshiyoshi FujiwaraHiroyuki Okada<h4>Objective</h4>The rare incidence of submucosal invasive non-ampullary duodenal carcinoma has led to scant information in literature; therefore, we compared the clinicopathological features between submucosal invasive carcinoma (SM-Ca), mucosal carcinoma (M-Ca), and advanced carcinoma (Ad-Ca).<h4>Materials</h4>We retrospectively analyzed 165 patients with sporadic non-ampullary duodenal carcinomas (SNADCs) from four institutions between January 2003 and December 2018. The SNADCs were divided to three groups according to histological diagnosis: SM-Ca, M-Ca, and Ad-Ca. The clinicopathological characteristics and mucin phenotypes were compared between groups.<h4>Results</h4>Among the 165 SNADCs, 11 (7%) were classified as SM-Ca, 70 (42%) as M-Ca, and 84 (51%) as Ad-Ca. We found that all SM-Ca (P = 0.013) and most Ad-Ca (P = 0.020) lesions were located on the oral-Vater; however, an almost equal distribution of M-Ca lesions was found between the oral- and anal-Vater. No significant difference was observed between the tumor diameter of M-Ca and SM-Ca; however, 45% (5/11) of SM-Ca were ≤10 mm. A total of 73% (8/11) of SM-Ca were classified as gastric phenotype and no lesions were classified as intestinal phenotype; whereas most M-Ca were classified as intestinal phenotype (67%, 8/12).<h4>Conclusions</h4>SM-Ca lesions were all located on the oral-Vater and were highly associated with the gastric mucin phenotype, which were different from the features of most M-Ca.https://doi.org/10.1371/journal.pone.0256797 |
| spellingShingle | Katsunori Matsueda Hiromitsu Kanzaki Ryuta Takenaka Masahiro Nakagawa Kazuhiro Matsueda Masaya Iwamuro Seiji Kawano Yoshiro Kawahara Tomohiro Toji Takehiro Tanaka Takahito Yagi Toshiyoshi Fujiwara Hiroyuki Okada Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer. PLoS ONE |
| title | Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer. |
| title_full | Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer. |
| title_fullStr | Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer. |
| title_full_unstemmed | Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer. |
| title_short | Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer. |
| title_sort | clinical and phenotypical characteristics of submucosal invasive carcinoma in non ampullary duodenal cancer |
| url | https://doi.org/10.1371/journal.pone.0256797 |
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