The Abundant Distribution and Duplication of SARS-CoV-2 in the Cerebrum and Lungs Promote a High Mortality Rate in Transgenic hACE2-C57 Mice

The Abundant Distribution and Duplication of SARS-CoV-2 in the Cerebrum and Lungs Promote a High Mortality Rate in Transgenic hACE2-C57 Mice

Patients with COVID-19 have been reported to experience neurological complications, although the main cause of death in these patients was determined to be lung damage. Notably, SARS-CoV-2-induced pathological injuries in brains with a viral presence were also found in all fatal animal cases. Thus,...

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Bibliographic Details
Main Authors:	Heng Li, Xin Zhao, Shasha Peng, Yingyan Li, Jing Li, Huiwen Zheng, Yifan Zhang, Yurong Zhao, Yuan Tian, Jinling Yang, Yibin Wang, Xinglong Zhang, Longding Liu
Format:	Article
Language:	English
Published:	MDPI AG 2024-01-01
Series:	International Journal of Molecular Sciences
Subjects:	SARS-CoV-2 cerebrum high mortality rate C57BL/6Smoc-<i>Ace2<sup>em3(hACE2-flag-Wpre-pA)Smoc</sup></i> mice Syrian hamsters viral distribution and duplication
Online Access:	https://www.mdpi.com/1422-0067/25/2/997

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