PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection

PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection

Summary: PYHIN proteins AIM2 and IFI204 sense pathogen DNA, while other PYHINs have been shown to regulate host gene expression through as-yet unclear mechanisms. We characterize mouse PYHIN IFI207, which we find is not involved in DNA sensing but rather is required for cytokine promoter induction i...

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Bibliographic Details
Main Authors: Marcin Baran, Claudia Feriotti, Aoife McGinley, Simon R. Carlile, Zhaozhao Jiang, Ricardo Calderon-Gonzalez, Amy Dumigan, Joana Sá-Pessoa, Caroline E. Sutton, Jay Kearney, Rachel M. McLoughlin, Kingston H.G. Mills, Katherine A. Fitzgerald, Jose A. Bengeochea, Andrew G. Bowie
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723003522

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