The unique characteristics of COVID-19 coagulopathy
Abstract Thrombotic complications and coagulopathy frequently occur in COVID-19. However, the characteristics of COVID-19-associated coagulopathy (CAC) are distinct from those seen with bacterial sepsis-induced coagulopathy (SIC) and disseminated intravascular coagulation (DIC), with CAC usually sho...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | Critical Care |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13054-020-03077-0 |
| _version_ | 1828870154538188800 |
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| author | Toshiaki Iba Jerrold H. Levy Jean Marie Connors Theodore E. Warkentin Jecko Thachil Marcel Levi |
| author_facet | Toshiaki Iba Jerrold H. Levy Jean Marie Connors Theodore E. Warkentin Jecko Thachil Marcel Levi |
| author_sort | Toshiaki Iba |
| collection | DOAJ |
| description | Abstract Thrombotic complications and coagulopathy frequently occur in COVID-19. However, the characteristics of COVID-19-associated coagulopathy (CAC) are distinct from those seen with bacterial sepsis-induced coagulopathy (SIC) and disseminated intravascular coagulation (DIC), with CAC usually showing increased D-dimer and fibrinogen levels but initially minimal abnormalities in prothrombin time and platelet count. Venous thromboembolism and arterial thrombosis are more frequent in CAC compared to SIC/DIC. Clinical and laboratory features of CAC overlap somewhat with a hemophagocytic syndrome, antiphospholipid syndrome, and thrombotic microangiopathy. We summarize the key characteristics of representative coagulopathies, discussing similarities and differences so as to define the unique character of CAC. |
| first_indexed | 2024-12-13T06:05:04Z |
| format | Article |
| id | doaj.art-f56f9079ba90414db7bf6ae355c7974c |
| institution | Directory Open Access Journal |
| issn | 1364-8535 |
| language | English |
| last_indexed | 2024-12-13T06:05:04Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Critical Care |
| spelling | doaj.art-f56f9079ba90414db7bf6ae355c7974c2022-12-21T23:57:14ZengBMCCritical Care1364-85352020-06-012411810.1186/s13054-020-03077-0The unique characteristics of COVID-19 coagulopathyToshiaki Iba0Jerrold H. Levy1Jean Marie Connors2Theodore E. Warkentin3Jecko Thachil4Marcel Levi5Department of Emergency and Disaster Medicine, Juntendo University Graduate School of MedicineDepartment of Anesthesiology, Critical Care, and Surgery, Duke University School of MedicineHematology Division Brigham and Women’s Hospital, Harvard Medical SchoolDepartment of Pathology and Molecular Medicine, and Department of Medicine, McMaster UniversityDepartment of Haematology, Manchester Royal InfirmaryDepartment of Medicine, University College London Hospitals NHS Foundation Trust and Cardio-metabolic Programme-NIHR UCLH/UCL BRC LondonAbstract Thrombotic complications and coagulopathy frequently occur in COVID-19. However, the characteristics of COVID-19-associated coagulopathy (CAC) are distinct from those seen with bacterial sepsis-induced coagulopathy (SIC) and disseminated intravascular coagulation (DIC), with CAC usually showing increased D-dimer and fibrinogen levels but initially minimal abnormalities in prothrombin time and platelet count. Venous thromboembolism and arterial thrombosis are more frequent in CAC compared to SIC/DIC. Clinical and laboratory features of CAC overlap somewhat with a hemophagocytic syndrome, antiphospholipid syndrome, and thrombotic microangiopathy. We summarize the key characteristics of representative coagulopathies, discussing similarities and differences so as to define the unique character of CAC.http://link.springer.com/article/10.1186/s13054-020-03077-0COVID-19CoagulopathyDisseminated intravascular coagulationHemophagocytic syndromeAntiphospholipid syndromeThrombotic microangiopathy |
| spellingShingle | Toshiaki Iba Jerrold H. Levy Jean Marie Connors Theodore E. Warkentin Jecko Thachil Marcel Levi The unique characteristics of COVID-19 coagulopathy Critical Care COVID-19 Coagulopathy Disseminated intravascular coagulation Hemophagocytic syndrome Antiphospholipid syndrome Thrombotic microangiopathy |
| title | The unique characteristics of COVID-19 coagulopathy |
| title_full | The unique characteristics of COVID-19 coagulopathy |
| title_fullStr | The unique characteristics of COVID-19 coagulopathy |
| title_full_unstemmed | The unique characteristics of COVID-19 coagulopathy |
| title_short | The unique characteristics of COVID-19 coagulopathy |
| title_sort | unique characteristics of covid 19 coagulopathy |
| topic | COVID-19 Coagulopathy Disseminated intravascular coagulation Hemophagocytic syndrome Antiphospholipid syndrome Thrombotic microangiopathy |
| url | http://link.springer.com/article/10.1186/s13054-020-03077-0 |
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