Genotoxicity analysis and identification of citrinin based on a systematic literature search
Citrinin （CIT） is a mycotoxin produced by several species of the genera Aspergillus， Penicillium， and Monascus， and it often contaminates grains and grain products. CIT shows clear nephrotoxicity， while its carcinogenicity evidence is insufficient. Considering the ability of genotoxicity tests to sc...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
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The Editorial Office of Chinese Journal of Food Hygiene
2023-08-01
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| Series: | Zhongguo shipin weisheng zazhi |
| Subjects: | |
| Online Access: | https://www.zgspws.com/zgspwszz/article/abstract/202308016?st=article_issue |
| _version_ | 1827346729859547136 |
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| author | WANG Kexin TAN Jianbin LI Qing CHEN Bifeng ZHAO Min |
| author_facet | WANG Kexin TAN Jianbin LI Qing CHEN Bifeng ZHAO Min |
| author_sort | WANG Kexin |
| collection | DOAJ |
| description | Citrinin （CIT） is a mycotoxin produced by several species of the genera Aspergillus， Penicillium， and Monascus， and it often contaminates grains and grain products. CIT shows clear nephrotoxicity， while its carcinogenicity evidence is insufficient. Considering the ability of genotoxicity tests to screen chemicals for potential carcinogenicity， the genotoxicity of CIT was reviewed from the perspective of three genetic endpoints， including genetic mutation， chromosomal aberrations， and DNA damage. CIT is a genotoxic substance that induces chromosomal aberrations. The mechanism may be related to its influence on tubulin polymerization and spindle formation during cellular mitosis， thereby causing cell cycle blocking. This study provides basic data for follow-up risk assessments of CIT. |
| first_indexed | 2024-03-07T23:35:59Z |
| format | Article |
| id | doaj.art-f56fdcc7bbfc4db69d5fc9d463b01cc5 |
| institution | Directory Open Access Journal |
| issn | 1004-8456 |
| language | zho |
| last_indexed | 2024-03-07T23:35:59Z |
| publishDate | 2023-08-01 |
| publisher | The Editorial Office of Chinese Journal of Food Hygiene |
| record_format | Article |
| series | Zhongguo shipin weisheng zazhi |
| spelling | doaj.art-f56fdcc7bbfc4db69d5fc9d463b01cc52024-02-20T07:50:45ZzhoThe Editorial Office of Chinese Journal of Food HygieneZhongguo shipin weisheng zazhi1004-84562023-08-013581235124110.13590/j.cjfh.2023.08.0161004-8456（2023）08-1235-07Genotoxicity analysis and identification of citrinin based on a systematic literature searchWANG Kexin0TAN Jianbin1LI Qing2CHEN Bifeng3ZHAO Min4Guangdong Provincial Center for Disease Control and Prevention, Guangdong Guangzhou 511430, ChinaGuangdong Provincial Center for Disease Control and Prevention, Guangdong Guangzhou 511430, ChinaGuangdong Provincial Center for Disease Control and Prevention, Guangdong Guangzhou 511430, ChinaGuangdong Provincial Center for Disease Control and Prevention, Guangdong Guangzhou 511430, ChinaGuangdong Provincial Center for Disease Control and Prevention, Guangdong Guangzhou 511430, ChinaCitrinin （CIT） is a mycotoxin produced by several species of the genera Aspergillus， Penicillium， and Monascus， and it often contaminates grains and grain products. CIT shows clear nephrotoxicity， while its carcinogenicity evidence is insufficient. Considering the ability of genotoxicity tests to screen chemicals for potential carcinogenicity， the genotoxicity of CIT was reviewed from the perspective of three genetic endpoints， including genetic mutation， chromosomal aberrations， and DNA damage. CIT is a genotoxic substance that induces chromosomal aberrations. The mechanism may be related to its influence on tubulin polymerization and spindle formation during cellular mitosis， thereby causing cell cycle blocking. This study provides basic data for follow-up risk assessments of CIT.https://www.zgspws.com/zgspwszz/article/abstract/202308016?st=article_issuecitriningenotoxicitygene mutationchromosome aberrationdna damage |
| spellingShingle | WANG Kexin TAN Jianbin LI Qing CHEN Bifeng ZHAO Min Genotoxicity analysis and identification of citrinin based on a systematic literature search Zhongguo shipin weisheng zazhi citrinin genotoxicity gene mutation chromosome aberration dna damage |
| title | Genotoxicity analysis and identification of citrinin based on a systematic literature search |
| title_full | Genotoxicity analysis and identification of citrinin based on a systematic literature search |
| title_fullStr | Genotoxicity analysis and identification of citrinin based on a systematic literature search |
| title_full_unstemmed | Genotoxicity analysis and identification of citrinin based on a systematic literature search |
| title_short | Genotoxicity analysis and identification of citrinin based on a systematic literature search |
| title_sort | genotoxicity analysis and identification of citrinin based on a systematic literature search |
| topic | citrinin genotoxicity gene mutation chromosome aberration dna damage |
| url | https://www.zgspws.com/zgspwszz/article/abstract/202308016?st=article_issue |
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