Praziquantel activates a native cation current in Schistosoma mansoni

Praziquantel activates a native cation current in Schistosoma mansoni

IntroductionPraziquantel (PZQ), an anthelmintic drug discovered in the 1970s, is still used to treat schistosomiasis and various other infections caused by parasitic flatworms. PZQ causes a triad of phenotypic effects on schistosome worms – rapid depolarization, muscle contraction, and damage throug...

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Bibliographic Details
Main Authors: Evgeny G. Chulkov, Claudia M. Rohr, Jonathan S. Marchant
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Parasitology
Subjects:
parasite
anthelmintic
schistosome
ion channel
TRP channel
Online Access:https://www.frontiersin.org/articles/10.3389/fpara.2023.1285177/full

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