The Role of c-KIT in Tumorigenesis: Evaluation in Canine Cutaneous Mast Cell Tumors

The Role of c-KIT in Tumorigenesis: Evaluation in Canine Cutaneous Mast Cell Tumors

The c-KIT proto-oncogene has been implicated in the pathogenesis of several neoplastic diseases, including gastrointestinal stromal tumors and mastocytosis in humans, and mast cell tumors (MCTs) in canines. Cutaneous MCTs are common neoplasms in dogs and have a variable biologic behavior. The goal o...

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Bibliographic Details
Main Authors: Joshua D. Webster, Vilma Yuzbasiyan-Gurkan, John B. Kaneene, RoseAnn Miller, James H. Resau, Matti Kiupel
Format: Article
Language:English
Published: Elsevier 2006-02-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
c-KIT
KIT
mutation
animal model
canine
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558606800199

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