Association between long-term static postures exposure and musculoskeletal disorders among university employees: A viewpoint of inflammatory pathways
BackgroundMusculoskeletal disorders (MSDs) are critical occupational and social problems. With the improvement of production mechanization and automation, and the widespread application of computers, more occupations are exposed to static postures and load. This study explored the role of inflammati...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.1055374/full |
| _version_ | 1811213528837652480 |
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| author | Yidan Dong Ping Jiang Xu Jin Nanyu Jiang Wenchu Huang Yu Peng Yuhong Shen Lihua He Mikael Forsman Mikael Forsman Liyun Yang Liyun Yang |
| author_facet | Yidan Dong Ping Jiang Xu Jin Nanyu Jiang Wenchu Huang Yu Peng Yuhong Shen Lihua He Mikael Forsman Mikael Forsman Liyun Yang Liyun Yang |
| author_sort | Yidan Dong |
| collection | DOAJ |
| description | BackgroundMusculoskeletal disorders (MSDs) are critical occupational and social problems. With the improvement of production mechanization and automation, and the widespread application of computers, more occupations are exposed to static postures and load. This study explored the role of inflammation in the association between static postures exposure and MSDs.MethodsThis study adopted a prospective nested case-control design in which 66 lower back MSDs cases and 66 healthy controls were selected from a cohort study of university employees. The personal information, postural load, musculoskeletal symptoms, pressure pain thresholds (PPTs), and inflammatory cytokines were collected. Logistic and linear regressions were used to investigate the association among postural load, inflammatory cytokines, and lower back MSDs. Mediation analysis was used to calculate the mediation effect.ResultsThe results of logistic and linear regressions showed that postural load and inflammatory cytokines were positively associated with lower back MSDs (P < 0.05), and postural load was positively associated with inflammatory cytokines (P < 0.05). Further, mediation analysis showed that the mediation effect of postural load on the lower back MSDs through TNF-α was 0.073 (95%CI: 0.025–0.128), and the mediation effect of posture load on the lower back MSDs through IL-6 was 0.098 (95%CI: 0.041–0.179), respectively.ConclusionStatic postures were associated with the occurrence of MSDs through inflammatory cytokines, and low-level inflammation may be a critical early event in the generation of MSDs. This study may help bridge the gap of potential mechanisms linking static postures to increased risks of MSDs, and provide new evidence for targeted protection against the global increasing MSDs. |
| first_indexed | 2024-04-12T05:48:03Z |
| format | Article |
| id | doaj.art-f57551d3315b4b88b84b266a0bf6ca80 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-12T05:48:03Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-f57551d3315b4b88b84b266a0bf6ca802022-12-22T03:45:25ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-12-011010.3389/fpubh.2022.10553741055374Association between long-term static postures exposure and musculoskeletal disorders among university employees: A viewpoint of inflammatory pathwaysYidan Dong0Ping Jiang1Xu Jin2Nanyu Jiang3Wenchu Huang4Yu Peng5Yuhong Shen6Lihua He7Mikael Forsman8Mikael Forsman9Liyun Yang10Liyun Yang11Department of Occupational and Environmental Health, School of Public Health, Peking University, Beijing, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Peking University, Beijing, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Peking University, Beijing, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Peking University, Beijing, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Peking University, Beijing, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Peking University, Beijing, ChinaInstitute of Quartermaster Engineering & Technology, Beijing, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Peking University, Beijing, ChinaDivision of Ergonomics, School of Engineering Sciences in Chemistry, Biotechnology, and Health, Royal Institute of Technology, Huddinge, SwedenUnit of Occupational Medicine, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SwedenDivision of Ergonomics, School of Engineering Sciences in Chemistry, Biotechnology, and Health, Royal Institute of Technology, Huddinge, SwedenUnit of Occupational Medicine, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SwedenBackgroundMusculoskeletal disorders (MSDs) are critical occupational and social problems. With the improvement of production mechanization and automation, and the widespread application of computers, more occupations are exposed to static postures and load. This study explored the role of inflammation in the association between static postures exposure and MSDs.MethodsThis study adopted a prospective nested case-control design in which 66 lower back MSDs cases and 66 healthy controls were selected from a cohort study of university employees. The personal information, postural load, musculoskeletal symptoms, pressure pain thresholds (PPTs), and inflammatory cytokines were collected. Logistic and linear regressions were used to investigate the association among postural load, inflammatory cytokines, and lower back MSDs. Mediation analysis was used to calculate the mediation effect.ResultsThe results of logistic and linear regressions showed that postural load and inflammatory cytokines were positively associated with lower back MSDs (P < 0.05), and postural load was positively associated with inflammatory cytokines (P < 0.05). Further, mediation analysis showed that the mediation effect of postural load on the lower back MSDs through TNF-α was 0.073 (95%CI: 0.025–0.128), and the mediation effect of posture load on the lower back MSDs through IL-6 was 0.098 (95%CI: 0.041–0.179), respectively.ConclusionStatic postures were associated with the occurrence of MSDs through inflammatory cytokines, and low-level inflammation may be a critical early event in the generation of MSDs. This study may help bridge the gap of potential mechanisms linking static postures to increased risks of MSDs, and provide new evidence for targeted protection against the global increasing MSDs.https://www.frontiersin.org/articles/10.3389/fpubh.2022.1055374/fullmusculoskeletal disorderslower back paininflammatory cytokinestatic posturesnested case-control studyuniversity employees |
| spellingShingle | Yidan Dong Ping Jiang Xu Jin Nanyu Jiang Wenchu Huang Yu Peng Yuhong Shen Lihua He Mikael Forsman Mikael Forsman Liyun Yang Liyun Yang Association between long-term static postures exposure and musculoskeletal disorders among university employees: A viewpoint of inflammatory pathways Frontiers in Public Health musculoskeletal disorders lower back pain inflammatory cytokine static postures nested case-control study university employees |
| title | Association between long-term static postures exposure and musculoskeletal disorders among university employees: A viewpoint of inflammatory pathways |
| title_full | Association between long-term static postures exposure and musculoskeletal disorders among university employees: A viewpoint of inflammatory pathways |
| title_fullStr | Association between long-term static postures exposure and musculoskeletal disorders among university employees: A viewpoint of inflammatory pathways |
| title_full_unstemmed | Association between long-term static postures exposure and musculoskeletal disorders among university employees: A viewpoint of inflammatory pathways |
| title_short | Association between long-term static postures exposure and musculoskeletal disorders among university employees: A viewpoint of inflammatory pathways |
| title_sort | association between long term static postures exposure and musculoskeletal disorders among university employees a viewpoint of inflammatory pathways |
| topic | musculoskeletal disorders lower back pain inflammatory cytokine static postures nested case-control study university employees |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.1055374/full |
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