Drug*placebo interaction effect may bias clinical trials interpretation: hybrid balanced placebo and randomized placebo-controlled design

Drug*placebo interaction effect may bias clinical trials interpretation: hybrid balanced placebo and randomized placebo-controlled design

Abstract Background Conventional randomized placebo-controlled study design assumes the absence of drug*placebo interaction. We hypothesized the presence of such an interaction and that conventionally estimated drug effect might be biased. The objectives of the study were to determine the drug*place...

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Bibliographic Details
Main Authors: Muhammad M. Hammami, Safa Hammami, Reem Al-Swayeh, Eman Al-Gaai, Faduma Abdi Farah, Sophia J. S. De Padua
Format: Article
Language:English
Published: BMC 2016-11-01
Series:BMC Medical Research Methodology
Subjects:
Balanced placebo design
Randomized placebo-controlled trials
Biased drug effect size
Drug placebo interaction
Effect modification
Online Access:http://link.springer.com/article/10.1186/s12874-016-0269-1

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