Enhanced functional synchronization of medial and lateral PFC underlies internally-guided action planning
Actions are often internally guided, reflecting our covert will and intentions. The dorsomedial prefrontal cortex, including the pre-Supplementary Motor Area (pre-SMA), has been implicated in the internally generated aspects of action planning, such as choice and intention. Yet, the mechanism by whi...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2012-04-01
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| Series: | Frontiers in Human Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2012.00079/full |
| _version_ | 1819047518740152320 |
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| author | Keren eRosenberg Katz Keren eRosenberg Katz Shahar eJamshy Shahar eJamshy Neomi eSinger Neomi eSinger Ilana ePodlipsky Svetlana eKipervasser Svetlana eKipervasser Fani eAndelman Miri eNeufeld Miri eNeufeld Nathan eIntrator Itzhak eFried Itzhak eFried Itzhak eFried Talma eHendler Talma eHendler Talma eHendler |
| author_facet | Keren eRosenberg Katz Keren eRosenberg Katz Shahar eJamshy Shahar eJamshy Neomi eSinger Neomi eSinger Ilana ePodlipsky Svetlana eKipervasser Svetlana eKipervasser Fani eAndelman Miri eNeufeld Miri eNeufeld Nathan eIntrator Itzhak eFried Itzhak eFried Itzhak eFried Talma eHendler Talma eHendler Talma eHendler |
| author_sort | Keren eRosenberg Katz |
| collection | DOAJ |
| description | Actions are often internally guided, reflecting our covert will and intentions. The dorsomedial prefrontal cortex, including the pre-Supplementary Motor Area (pre-SMA), has been implicated in the internally generated aspects of action planning, such as choice and intention. Yet, the mechanism by which this area interacts with other cognitive brain regions such as the dorsolateral prefrontal cortex, a central node in decision making, is still unclear. To shed light on this mechanism, brain activity was measured via fMRI and intracranial EEG in two studies during the performance of visually cued repeated finger tapping in which the choice of finger was guided by either a presented number (external) or self choice (internal). A functional-MRI study in 15 healthy participants demonstrated that the pre-SMA, compared to the SMA proper, was more active and also more functionally-correlated with the dorsolateral prefrontal cortex during internally- compared to externally- guided action planning (p<0.05, random effect). In a similar manner, an intracranial-EEG study in 5 epilepsy patients showed greater inter-regional gamma related connectivity between electrodes situated in medial and lateral aspects of the prefrontal cortex for internally- compared to externally-guided actions. Although this finding was observed for groups of electrodes situated both in the pre-SMA and SMA-proper, increased intra-cluster gamma related connectivity was only observed for the pre-SMA (sign-test, p<0.0001). Overall our findings provide multi-scale indications for the involvement of the dorsomedial prefrontal cortex, and especially the pre-SMA, in generating internally-guided motor planning. Our intracranial-EEG results further point to enhanced functional connectivity between decision making- and motor planning aspects of the PFC, as a possible neural mechanism for internally generated action planning. |
| first_indexed | 2024-12-21T11:01:38Z |
| format | Article |
| id | doaj.art-f577b9c7eb55444a98170acbc8501a2c |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-21T11:01:38Z |
| publishDate | 2012-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-f577b9c7eb55444a98170acbc8501a2c2022-12-21T19:06:20ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612012-04-01610.3389/fnhum.2012.0007921257Enhanced functional synchronization of medial and lateral PFC underlies internally-guided action planningKeren eRosenberg Katz0Keren eRosenberg Katz1Shahar eJamshy2Shahar eJamshy3Neomi eSinger4Neomi eSinger5Ilana ePodlipsky6Svetlana eKipervasser7Svetlana eKipervasser8Fani eAndelman9Miri eNeufeld10Miri eNeufeld11Nathan eIntrator12Itzhak eFried13Itzhak eFried14Itzhak eFried15Talma eHendler16Talma eHendler17Talma eHendler18Tel-Aviv Medical CenterTel-Aviv UniversityTel-Aviv Medical CenterTel-Aviv UniversityTel-Aviv Medical CenterTel Aviv UniversityTel-Aviv Medical CenterTel-Aviv Sourasky Medical CenterTel-Aviv UniversityTel-Aviv Sourasky Medical CenterTel-Aviv Sourasky Medical CenterTel-Aviv UniversityTel-Aviv UniversityTel-Aviv Sourasky Medical CenterTel-Aviv UniversityUniversity of CaliforniaTel-Aviv Medical CenterTel-Aviv UniversityTel Aviv UniversityActions are often internally guided, reflecting our covert will and intentions. The dorsomedial prefrontal cortex, including the pre-Supplementary Motor Area (pre-SMA), has been implicated in the internally generated aspects of action planning, such as choice and intention. Yet, the mechanism by which this area interacts with other cognitive brain regions such as the dorsolateral prefrontal cortex, a central node in decision making, is still unclear. To shed light on this mechanism, brain activity was measured via fMRI and intracranial EEG in two studies during the performance of visually cued repeated finger tapping in which the choice of finger was guided by either a presented number (external) or self choice (internal). A functional-MRI study in 15 healthy participants demonstrated that the pre-SMA, compared to the SMA proper, was more active and also more functionally-correlated with the dorsolateral prefrontal cortex during internally- compared to externally- guided action planning (p<0.05, random effect). In a similar manner, an intracranial-EEG study in 5 epilepsy patients showed greater inter-regional gamma related connectivity between electrodes situated in medial and lateral aspects of the prefrontal cortex for internally- compared to externally-guided actions. Although this finding was observed for groups of electrodes situated both in the pre-SMA and SMA-proper, increased intra-cluster gamma related connectivity was only observed for the pre-SMA (sign-test, p<0.0001). Overall our findings provide multi-scale indications for the involvement of the dorsomedial prefrontal cortex, and especially the pre-SMA, in generating internally-guided motor planning. Our intracranial-EEG results further point to enhanced functional connectivity between decision making- and motor planning aspects of the PFC, as a possible neural mechanism for internally generated action planning.http://journal.frontiersin.org/Journal/10.3389/fnhum.2012.00079/fullPrefrontal CortexfMRIgamma bandFinger-tappingiEEGinternally guided |
| spellingShingle | Keren eRosenberg Katz Keren eRosenberg Katz Shahar eJamshy Shahar eJamshy Neomi eSinger Neomi eSinger Ilana ePodlipsky Svetlana eKipervasser Svetlana eKipervasser Fani eAndelman Miri eNeufeld Miri eNeufeld Nathan eIntrator Itzhak eFried Itzhak eFried Itzhak eFried Talma eHendler Talma eHendler Talma eHendler Enhanced functional synchronization of medial and lateral PFC underlies internally-guided action planning Frontiers in Human Neuroscience Prefrontal Cortex fMRI gamma band Finger-tapping iEEG internally guided |
| title | Enhanced functional synchronization of medial and lateral PFC underlies internally-guided action planning |
| title_full | Enhanced functional synchronization of medial and lateral PFC underlies internally-guided action planning |
| title_fullStr | Enhanced functional synchronization of medial and lateral PFC underlies internally-guided action planning |
| title_full_unstemmed | Enhanced functional synchronization of medial and lateral PFC underlies internally-guided action planning |
| title_short | Enhanced functional synchronization of medial and lateral PFC underlies internally-guided action planning |
| title_sort | enhanced functional synchronization of medial and lateral pfc underlies internally guided action planning |
| topic | Prefrontal Cortex fMRI gamma band Finger-tapping iEEG internally guided |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2012.00079/full |
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