SARS-CoV-2 infection increases the gene expression profile for Alzheimer’s disease risk
The coronavirus disease 2019 (COVID-19) pandemic has caused over 600,000,000 infections globally thus far. Up to 30% of individuals with mild to severe disease develop long COVID, exhibiting diverse neurologic symptoms including dementias. However, there is a paucity of knowledge of molecular brain...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Molecular Therapy: Methods & Clinical Development |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2329050122001322 |
| _version_ | 1811247798955278336 |
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| author | Ryan Green Karthick Mayilsamy Andrew R. McGill Taylor E. Martinez Bala Chandran Laura J. Blair Paula C. Bickford Shyam S. Mohapatra Subhra Mohapatra |
| author_facet | Ryan Green Karthick Mayilsamy Andrew R. McGill Taylor E. Martinez Bala Chandran Laura J. Blair Paula C. Bickford Shyam S. Mohapatra Subhra Mohapatra |
| author_sort | Ryan Green |
| collection | DOAJ |
| description | The coronavirus disease 2019 (COVID-19) pandemic has caused over 600,000,000 infections globally thus far. Up to 30% of individuals with mild to severe disease develop long COVID, exhibiting diverse neurologic symptoms including dementias. However, there is a paucity of knowledge of molecular brain markers and whether these can precipitate the onset of Alzheimer’s disease (AD). Herein, we report the brain gene expression profiles of severe COVID-19 patients showing increased expression of innate immune response genes and genes implicated in AD pathogenesis. The use of a mouse-adapted strain of SARS-CoV-2 (MA10) in an aged mouse model shows evidence of viral neurotropism, prolonged viral infection, increased expression of tau aggregator FKBP51, interferon-inducible gene Ifi204, and complement genes C4 and C5AR1. Brain histopathology shows AD signatures including increased tau-phosphorylation, tau-oligomerization, and α-synuclein expression in aged MA10 infected mice. The results of gene expression profiling of SARS-CoV-2-infected and AD brains and studies in the MA10 aged mouse model taken together, for the first time provide evidence suggesting that SARS-CoV-2 infection alters expression of genes in the brain associated with the development of AD. Future studies of common molecular markers in SARS-CoV-2 infection and AD could be useful for developing novel therapies targeting AD. |
| first_indexed | 2024-04-12T15:15:49Z |
| format | Article |
| id | doaj.art-f5788a47b7924c8db7fe23ddaa442896 |
| institution | Directory Open Access Journal |
| issn | 2329-0501 |
| language | English |
| last_indexed | 2024-04-12T15:15:49Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Therapy: Methods & Clinical Development |
| spelling | doaj.art-f5788a47b7924c8db7fe23ddaa4428962022-12-22T03:27:37ZengElsevierMolecular Therapy: Methods & Clinical Development2329-05012022-12-0127217229SARS-CoV-2 infection increases the gene expression profile for Alzheimer’s disease riskRyan Green0Karthick Mayilsamy1Andrew R. McGill2Taylor E. Martinez3Bala Chandran4Laura J. Blair5Paula C. Bickford6Shyam S. Mohapatra7Subhra Mohapatra8Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; James A Haley VA Hospital, Tampa, FL 33612, USADepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; James A Haley VA Hospital, Tampa, FL 33612, USADepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; James A Haley VA Hospital, Tampa, FL 33612, USADepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; James A Haley VA Hospital, Tampa, FL 33612, USADepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USADepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; Byrd Alzheimer’s Research Institute, University of South Florida, Tampa, FL 33613, USA; James A Haley VA Hospital, Tampa, FL 33612, USACenter of Excellence for Aging and Brain Repair, Departments of Neurosurgery and Brain Repair, and Molecular Pharmacology and Physiology, Morsani College of Medicine, Tampa, FL 33613, USA; James A Haley VA Hospital, Tampa, FL 33612, USADepartment of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; James A Haley VA Hospital, Tampa, FL 33612, USADepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; James A Haley VA Hospital, Tampa, FL 33612, USA; Corresponding author Subhra Mohapatra, Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.The coronavirus disease 2019 (COVID-19) pandemic has caused over 600,000,000 infections globally thus far. Up to 30% of individuals with mild to severe disease develop long COVID, exhibiting diverse neurologic symptoms including dementias. However, there is a paucity of knowledge of molecular brain markers and whether these can precipitate the onset of Alzheimer’s disease (AD). Herein, we report the brain gene expression profiles of severe COVID-19 patients showing increased expression of innate immune response genes and genes implicated in AD pathogenesis. The use of a mouse-adapted strain of SARS-CoV-2 (MA10) in an aged mouse model shows evidence of viral neurotropism, prolonged viral infection, increased expression of tau aggregator FKBP51, interferon-inducible gene Ifi204, and complement genes C4 and C5AR1. Brain histopathology shows AD signatures including increased tau-phosphorylation, tau-oligomerization, and α-synuclein expression in aged MA10 infected mice. The results of gene expression profiling of SARS-CoV-2-infected and AD brains and studies in the MA10 aged mouse model taken together, for the first time provide evidence suggesting that SARS-CoV-2 infection alters expression of genes in the brain associated with the development of AD. Future studies of common molecular markers in SARS-CoV-2 infection and AD could be useful for developing novel therapies targeting AD.http://www.sciencedirect.com/science/article/pii/S2329050122001322SARS CoV-2COVID-19Alzheimer’s diseaseneuroinflammation |
| spellingShingle | Ryan Green Karthick Mayilsamy Andrew R. McGill Taylor E. Martinez Bala Chandran Laura J. Blair Paula C. Bickford Shyam S. Mohapatra Subhra Mohapatra SARS-CoV-2 infection increases the gene expression profile for Alzheimer’s disease risk Molecular Therapy: Methods & Clinical Development SARS CoV-2 COVID-19 Alzheimer’s disease neuroinflammation |
| title | SARS-CoV-2 infection increases the gene expression profile for Alzheimer’s disease risk |
| title_full | SARS-CoV-2 infection increases the gene expression profile for Alzheimer’s disease risk |
| title_fullStr | SARS-CoV-2 infection increases the gene expression profile for Alzheimer’s disease risk |
| title_full_unstemmed | SARS-CoV-2 infection increases the gene expression profile for Alzheimer’s disease risk |
| title_short | SARS-CoV-2 infection increases the gene expression profile for Alzheimer’s disease risk |
| title_sort | sars cov 2 infection increases the gene expression profile for alzheimer s disease risk |
| topic | SARS CoV-2 COVID-19 Alzheimer’s disease neuroinflammation |
| url | http://www.sciencedirect.com/science/article/pii/S2329050122001322 |
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