Efficacy of solid dispersion of fenbendazole against gastrointestinal strongylatosis of young cattle
The purpose of the research is to study the efficacy of solid dispersion of fenbendazole (SDF) against nematodoses of young cattle.Materials and methods. The study of SDF, obtained by mechanochemical processing of fenbendazole substance with polyvinylpyrrolidone (PVP) polymer, was carried out on 126...
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Federal Scientific Centre VIEV
2021-03-01
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| Series: | Российский паразитологический журнал |
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| Online Access: | https://vniigis.elpub.ru/jour/article/view/721 |
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| author | A. I. Varlamova I. A. Arkhipov K. M. Sadov S. S. Khalikov M. V. Arisov E. N. Borzunov |
| author_facet | A. I. Varlamova I. A. Arkhipov K. M. Sadov S. S. Khalikov M. V. Arisov E. N. Borzunov |
| author_sort | A. I. Varlamova |
| collection | DOAJ |
| description | The purpose of the research is to study the efficacy of solid dispersion of fenbendazole (SDF) against nematodoses of young cattle.Materials and methods. The study of SDF, obtained by mechanochemical processing of fenbendazole substance with polyvinylpyrrolidone (PVP) polymer, was carried out on 126 young cattle naturally infected with nematodiroses and other gastrointestinal strongylatoses. The animals were divided into 6 experimental groups of 10–11 animals each and SDF was administered once orally at doses of 2.0; 3.0 and 4.0 mg/kg of active substance (a.s.) (I-III groups) in comparison with the mechanical mixture of fenbendazole (FBZ) and PVP in a ratio of 1:9 (IV group) and substance FBZ at a dose of 3.0 mg/kg (group V) against each helminthosis. The control group of animals did not receive the drugs. Anthelmintic efficacy was evaluated in the "control test" based on the data of ovoscopic examination of feces of young cattle by flotation method before and 17 days after drugs administration.Results and discussion. SDF with PVP at a dose of 2.0; 3.0 and 4.0 mg/kg of a.s. in the form of a 10% powder showed respectively 88.4; 97.3 and 100% efficiency at nematodiroses and 89.2; 98.4 and 99.5 % activity against other types of gastrointestinal strongylates upon obtaining 32.3 and 32.4 % effect of the mechanical mixture of FBZ with PVP and 29.7 and 27.4% efficiency of the base preparation at a dose of 3.0 mg/kg. SDF showed 88.4; 97.3 and 100% of efficacy at doses of 2.0; 3.0 and 4.0 mg/kg of a.s., respectively, against nematodiroses and 89.2; 98.4 and 99.5% against other gastrointestinal strongylatoses in the form of 10% powder. It should be noted that mechanical mixture of PBZ with PVP showed 32.3 and 32.4% efficacy and the efficacy of the basic drug was 29.7 and 27.4% at a dose of 3.0 mg/kg against each helminthosis. |
| first_indexed | 2024-03-08T21:40:36Z |
| format | Article |
| id | doaj.art-f57ac86a6aff4b32a7ca31fc1495c88f |
| institution | Directory Open Access Journal |
| issn | 1998-8435 2541-7843 |
| language | Russian |
| last_indexed | 2024-04-25T02:04:35Z |
| publishDate | 2021-03-01 |
| publisher | Federal Scientific Centre VIEV |
| record_format | Article |
| series | Российский паразитологический журнал |
| spelling | doaj.art-f57ac86a6aff4b32a7ca31fc1495c88f2024-03-07T14:34:31ZrusFederal Scientific Centre VIEVРоссийский паразитологический журнал1998-84352541-78432021-03-01151929710.31016/1998-8435-2021-15-1-92-97627Efficacy of solid dispersion of fenbendazole against gastrointestinal strongylatosis of young cattleA. I. Varlamova0I. A. Arkhipov1K. M. Sadov2S. S. Khalikov3M. V. Arisov4E. N. Borzunov5All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution “Federal Scientific Centre VIEV”All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution “Federal Scientific Centre VIEV”All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution “Federal Scientific Centre VIEV”Nesmeyanov Institute of Organoelement Compounds of Russian Academy of SciencesAll-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution “Federal Scientific Centre VIEV”All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution “Federal Scientific Centre VIEV”The purpose of the research is to study the efficacy of solid dispersion of fenbendazole (SDF) against nematodoses of young cattle.Materials and methods. The study of SDF, obtained by mechanochemical processing of fenbendazole substance with polyvinylpyrrolidone (PVP) polymer, was carried out on 126 young cattle naturally infected with nematodiroses and other gastrointestinal strongylatoses. The animals were divided into 6 experimental groups of 10–11 animals each and SDF was administered once orally at doses of 2.0; 3.0 and 4.0 mg/kg of active substance (a.s.) (I-III groups) in comparison with the mechanical mixture of fenbendazole (FBZ) and PVP in a ratio of 1:9 (IV group) and substance FBZ at a dose of 3.0 mg/kg (group V) against each helminthosis. The control group of animals did not receive the drugs. Anthelmintic efficacy was evaluated in the "control test" based on the data of ovoscopic examination of feces of young cattle by flotation method before and 17 days after drugs administration.Results and discussion. SDF with PVP at a dose of 2.0; 3.0 and 4.0 mg/kg of a.s. in the form of a 10% powder showed respectively 88.4; 97.3 and 100% efficiency at nematodiroses and 89.2; 98.4 and 99.5 % activity against other types of gastrointestinal strongylates upon obtaining 32.3 and 32.4 % effect of the mechanical mixture of FBZ with PVP and 29.7 and 27.4% efficiency of the base preparation at a dose of 3.0 mg/kg. SDF showed 88.4; 97.3 and 100% of efficacy at doses of 2.0; 3.0 and 4.0 mg/kg of a.s., respectively, against nematodiroses and 89.2; 98.4 and 99.5% against other gastrointestinal strongylatoses in the form of 10% powder. It should be noted that mechanical mixture of PBZ with PVP showed 32.3 and 32.4% efficacy and the efficacy of the basic drug was 29.7 and 27.4% at a dose of 3.0 mg/kg against each helminthosis.https://vniigis.elpub.ru/jour/article/view/721fenbendazolesolid dispersionpolyvinylpyrrolidoneefficacystrongylatescattle |
| spellingShingle | A. I. Varlamova I. A. Arkhipov K. M. Sadov S. S. Khalikov M. V. Arisov E. N. Borzunov Efficacy of solid dispersion of fenbendazole against gastrointestinal strongylatosis of young cattle Российский паразитологический журнал fenbendazole solid dispersion polyvinylpyrrolidone efficacy strongylates cattle |
| title | Efficacy of solid dispersion of fenbendazole against gastrointestinal strongylatosis of young cattle |
| title_full | Efficacy of solid dispersion of fenbendazole against gastrointestinal strongylatosis of young cattle |
| title_fullStr | Efficacy of solid dispersion of fenbendazole against gastrointestinal strongylatosis of young cattle |
| title_full_unstemmed | Efficacy of solid dispersion of fenbendazole against gastrointestinal strongylatosis of young cattle |
| title_short | Efficacy of solid dispersion of fenbendazole against gastrointestinal strongylatosis of young cattle |
| title_sort | efficacy of solid dispersion of fenbendazole against gastrointestinal strongylatosis of young cattle |
| topic | fenbendazole solid dispersion polyvinylpyrrolidone efficacy strongylates cattle |
| url | https://vniigis.elpub.ru/jour/article/view/721 |
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