Coordinated Formation of IMPDH2 Cytoophidium in Mouse Oocytes and Granulosa Cells

Coordinated Formation of IMPDH2 Cytoophidium in Mouse Oocytes and Granulosa Cells

Inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme catalyzing de novo biosynthesis of guanine nucleotides, aggregates under certain circumstances into a type of non-membranous filamentous macrostructure termed “cytoophidium” or “rod and ring” in several types of cells. However, th...

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Bibliographic Details
Main Authors: Shiwen Ni, Teng Zhang, Chenmin Zhou, Min Long, Xuan Hou, Liji You, Hui Li, Lanying Shi, You-Qiang Su
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
IMPDH2
cytoophidium
oocyte maturation
granulosa cell
mycophenolic acid
guanine nucleotide
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.690536/full

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