Ultra-Hypofractionation for Whole-Breast Irradiation in Early Breast Cancer: Interim Analysis of a Prospective Study
We report on the early clinical outcomes of a prospective series of early breast cancer (EBC) patients treated with ultra-hypofractionated post-operative whole-breast irradiation (WBI) after breast-conserving surgery (BCS) and axillary management. Primary endpoints were patient’s compliance and acut...
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MDPI AG
2022-10-01
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| Online Access: | https://www.mdpi.com/2227-9059/10/10/2568 |
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| author | Valeria Sigaudi Micol Zannetti Eleonora Ferrara Irene Manfredda Eleonora Mones Gianfranco Loi Marco Krengli Pierfrancesco Franco |
| author_facet | Valeria Sigaudi Micol Zannetti Eleonora Ferrara Irene Manfredda Eleonora Mones Gianfranco Loi Marco Krengli Pierfrancesco Franco |
| author_sort | Valeria Sigaudi |
| collection | DOAJ |
| description | We report on the early clinical outcomes of a prospective series of early breast cancer (EBC) patients treated with ultra-hypofractionated post-operative whole-breast irradiation (WBI) after breast-conserving surgery (BCS) and axillary management. Primary endpoints were patient’s compliance and acute toxicity. Secondary endpoints included physician-rated cosmesis and ipsilateral breast tumour recurrence (IBTR). Acute toxicity was evaluated at the end of WBI, 3 weeks and 6 months thereafter, according to the Common Terminology Criteria for Adverse Events (v. 5.0). Patients were treated between September 2021 and May 2022. The treatment schedule for WBI consisted of either 26 Gy in 5 fractions over one week (standard approach) or 28.5 Gy in 5 fractions over 5 weeks (reserved to elders). Inverse planned intensity-modulated radiation therapy (IMRT) was used employing a static technique. A total of 70 patients were treated. Fifty-nine were treated with the 26 Gy/5 fr/1 w and 11 with the 28.5 Gy/5 fr/5 ws schedule. Median age was 67 and 70 in the two groups. Most of the patients had left-sided tumours (53.2%) in the 26 Gy/5 fr/1 w or right-sided lesions (63.6%) in the 28.5 Gy/5 fr/5 ws group. Most of the patients had a clinical T1N0 disease and a pathological pT1pN0(sn) after surgery. Ductal invasive carcinoma was the most frequent histology. Luminal A intrinsic subtyping was most frequent. Most of the patients underwent BCS and sentinel lymph node biopsy and adjuvant endocrine therapy. All patients completed the treatment program as planned. Maximum detected acute skin toxicities were grade 2 erythema (6.7%), grade 2 induration (4.4%), and grade 2 skin colour changes. No early IBTR was observed. Ultra-hypofractionated WBI provides favourable compliance and early clinical outcomes in EBC after BCS in a real-world setting. |
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| spelling | doaj.art-f57bfe2cb3f84f07934ecf847a2f09922023-11-23T23:05:13ZengMDPI AGBiomedicines2227-90592022-10-011010256810.3390/biomedicines10102568Ultra-Hypofractionation for Whole-Breast Irradiation in Early Breast Cancer: Interim Analysis of a Prospective StudyValeria Sigaudi0Micol Zannetti1Eleonora Ferrara2Irene Manfredda3Eleonora Mones4Gianfranco Loi5Marco Krengli6Pierfrancesco Franco7Department of Translational Medicine (DIMET), University of Eastern Piedmont, 28100 Novara, ItalyDepartment of Translational Medicine (DIMET), University of Eastern Piedmont, 28100 Novara, ItalyDepartment of Radiation Oncology, Maggiore della Carità University Hospital, 28100 Novara, ItalyDepartment of Radiation Oncology, Maggiore della Carità University Hospital, 28100 Novara, ItalyDepartment of Medical Physics, Maggiore della Carità University Hospital, 28100 Novara, ItalyDepartment of Medical Physics, Maggiore della Carità University Hospital, 28100 Novara, ItalyDepartment of Translational Medicine (DIMET), University of Eastern Piedmont, 28100 Novara, ItalyDepartment of Translational Medicine (DIMET), University of Eastern Piedmont, 28100 Novara, ItalyWe report on the early clinical outcomes of a prospective series of early breast cancer (EBC) patients treated with ultra-hypofractionated post-operative whole-breast irradiation (WBI) after breast-conserving surgery (BCS) and axillary management. Primary endpoints were patient’s compliance and acute toxicity. Secondary endpoints included physician-rated cosmesis and ipsilateral breast tumour recurrence (IBTR). Acute toxicity was evaluated at the end of WBI, 3 weeks and 6 months thereafter, according to the Common Terminology Criteria for Adverse Events (v. 5.0). Patients were treated between September 2021 and May 2022. The treatment schedule for WBI consisted of either 26 Gy in 5 fractions over one week (standard approach) or 28.5 Gy in 5 fractions over 5 weeks (reserved to elders). Inverse planned intensity-modulated radiation therapy (IMRT) was used employing a static technique. A total of 70 patients were treated. Fifty-nine were treated with the 26 Gy/5 fr/1 w and 11 with the 28.5 Gy/5 fr/5 ws schedule. Median age was 67 and 70 in the two groups. Most of the patients had left-sided tumours (53.2%) in the 26 Gy/5 fr/1 w or right-sided lesions (63.6%) in the 28.5 Gy/5 fr/5 ws group. Most of the patients had a clinical T1N0 disease and a pathological pT1pN0(sn) after surgery. Ductal invasive carcinoma was the most frequent histology. Luminal A intrinsic subtyping was most frequent. Most of the patients underwent BCS and sentinel lymph node biopsy and adjuvant endocrine therapy. All patients completed the treatment program as planned. Maximum detected acute skin toxicities were grade 2 erythema (6.7%), grade 2 induration (4.4%), and grade 2 skin colour changes. No early IBTR was observed. Ultra-hypofractionated WBI provides favourable compliance and early clinical outcomes in EBC after BCS in a real-world setting.https://www.mdpi.com/2227-9059/10/10/2568early breast cancerradiotherapyhypofractionationultra-hypofractionationbreast-conserving surgeryradiation |
| spellingShingle | Valeria Sigaudi Micol Zannetti Eleonora Ferrara Irene Manfredda Eleonora Mones Gianfranco Loi Marco Krengli Pierfrancesco Franco Ultra-Hypofractionation for Whole-Breast Irradiation in Early Breast Cancer: Interim Analysis of a Prospective Study Biomedicines early breast cancer radiotherapy hypofractionation ultra-hypofractionation breast-conserving surgery radiation |
| title | Ultra-Hypofractionation for Whole-Breast Irradiation in Early Breast Cancer: Interim Analysis of a Prospective Study |
| title_full | Ultra-Hypofractionation for Whole-Breast Irradiation in Early Breast Cancer: Interim Analysis of a Prospective Study |
| title_fullStr | Ultra-Hypofractionation for Whole-Breast Irradiation in Early Breast Cancer: Interim Analysis of a Prospective Study |
| title_full_unstemmed | Ultra-Hypofractionation for Whole-Breast Irradiation in Early Breast Cancer: Interim Analysis of a Prospective Study |
| title_short | Ultra-Hypofractionation for Whole-Breast Irradiation in Early Breast Cancer: Interim Analysis of a Prospective Study |
| title_sort | ultra hypofractionation for whole breast irradiation in early breast cancer interim analysis of a prospective study |
| topic | early breast cancer radiotherapy hypofractionation ultra-hypofractionation breast-conserving surgery radiation |
| url | https://www.mdpi.com/2227-9059/10/10/2568 |
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