Potential Incompatibility Problem of Intravenous Drugs’ Administration among Intensive Care Unit (ICU) Patients at PKU Muhammadiyah Yogyakarta Hospital
Drugs’ administration among hospitalized patients in ICU commonly is given intravenously. Mixing the intravenous drugs may result in incompatibility problem that might affect the drugs’ stability and bioavailability. The aim of the study was to investigate the potential incompatibility problem of i...
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| Format: | Article |
| Language: | Indonesian |
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Universitas Gadjah Mada
2019-12-01
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| Series: | Jurnal Manajemen dan Pelayanan Farmasi |
| Subjects: | |
| Online Access: | https://jurnal.ugm.ac.id/jmpf/article/view/40930 |
| _version_ | 1828854359774986240 |
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| author | Ardhanarishwari Umi Salamah Fita Rahmawati Fivy Kurniawati |
| author_facet | Ardhanarishwari Umi Salamah Fita Rahmawati Fivy Kurniawati |
| author_sort | Ardhanarishwari Umi Salamah |
| collection | DOAJ |
| description | Drugs’ administration among hospitalized patients in ICU commonly is given intravenously. Mixing the intravenous drugs may result in incompatibility problem that might affect the drugs’ stability and bioavailability. The aim of the study was to investigate the potential incompatibility problem of intravenous mixing drugs’ administration among ICU patients at PKU Muhammadiyah Yogyakarta Hospital. This study was a cross-sectional study in which design and data was obtained from ICU patients’ medical record retrospectively with purposive sampling in order to observe the pattern of intravenous drug’s combination. The potential incompatibility problem was analyzed using Handbook on Injectable Drugs. There were 79 out of 119 medical records which fulfilled sample inclusion criteria taken in this study. Parenteral dosage form was commonly used rather than non parenteral (62.06%) among ICUs’ patients. The potential incompatibility pattern consisted of incompatibility of intravenous drugs, electrolyte solutions/parenteral nutritions in mixture form, and the electrolyte solutions/parenteral nutritions, which are administrated simultaneously. Potential incompatibility of intravenous dosage was found in 50 events out of 79 patients (0.63 events per patients), which consisted of 8 events (8.51%) in using of drugs administrated simultaneously, 10 events (19.23%) in using of electrolyte solutions/parenteral nutritions in mixture form, and 32 events (11.72%) in using of electrolyte solutions/parenteral nutritions administrated simultaneously. Common potential incompatibilities types were precipitation of drugs and drug’s adsorption to packaging materials. |
| first_indexed | 2024-12-13T00:32:42Z |
| format | Article |
| id | doaj.art-f57ccd4e6975443a8a146478693bd022 |
| institution | Directory Open Access Journal |
| issn | 2088-8139 2443-2946 |
| language | Indonesian |
| last_indexed | 2024-12-13T00:32:42Z |
| publishDate | 2019-12-01 |
| publisher | Universitas Gadjah Mada |
| record_format | Article |
| series | Jurnal Manajemen dan Pelayanan Farmasi |
| spelling | doaj.art-f57ccd4e6975443a8a146478693bd0222022-12-22T00:05:18ZindUniversitas Gadjah MadaJurnal Manajemen dan Pelayanan Farmasi2088-81392443-29462019-12-019423824210.22146/jmpf.4093026059Potential Incompatibility Problem of Intravenous Drugs’ Administration among Intensive Care Unit (ICU) Patients at PKU Muhammadiyah Yogyakarta HospitalArdhanarishwari Umi Salamah0Fita Rahmawati1Fivy Kurniawati2Fakultas Farmasi, Universitas Gadjah MadaFakultas Farmasi, Universitas Gadjah MadaFakultas Farmasi, Universitas Gadjah MadaDrugs’ administration among hospitalized patients in ICU commonly is given intravenously. Mixing the intravenous drugs may result in incompatibility problem that might affect the drugs’ stability and bioavailability. The aim of the study was to investigate the potential incompatibility problem of intravenous mixing drugs’ administration among ICU patients at PKU Muhammadiyah Yogyakarta Hospital. This study was a cross-sectional study in which design and data was obtained from ICU patients’ medical record retrospectively with purposive sampling in order to observe the pattern of intravenous drug’s combination. The potential incompatibility problem was analyzed using Handbook on Injectable Drugs. There were 79 out of 119 medical records which fulfilled sample inclusion criteria taken in this study. Parenteral dosage form was commonly used rather than non parenteral (62.06%) among ICUs’ patients. The potential incompatibility pattern consisted of incompatibility of intravenous drugs, electrolyte solutions/parenteral nutritions in mixture form, and the electrolyte solutions/parenteral nutritions, which are administrated simultaneously. Potential incompatibility of intravenous dosage was found in 50 events out of 79 patients (0.63 events per patients), which consisted of 8 events (8.51%) in using of drugs administrated simultaneously, 10 events (19.23%) in using of electrolyte solutions/parenteral nutritions in mixture form, and 32 events (11.72%) in using of electrolyte solutions/parenteral nutritions administrated simultaneously. Common potential incompatibilities types were precipitation of drugs and drug’s adsorption to packaging materials.https://jurnal.ugm.ac.id/jmpf/article/view/40930incompatibilityintravenousintensive care unit |
| spellingShingle | Ardhanarishwari Umi Salamah Fita Rahmawati Fivy Kurniawati Potential Incompatibility Problem of Intravenous Drugs’ Administration among Intensive Care Unit (ICU) Patients at PKU Muhammadiyah Yogyakarta Hospital Jurnal Manajemen dan Pelayanan Farmasi incompatibility intravenous intensive care unit |
| title | Potential Incompatibility Problem of Intravenous Drugs’ Administration among Intensive Care Unit (ICU) Patients at PKU Muhammadiyah Yogyakarta Hospital |
| title_full | Potential Incompatibility Problem of Intravenous Drugs’ Administration among Intensive Care Unit (ICU) Patients at PKU Muhammadiyah Yogyakarta Hospital |
| title_fullStr | Potential Incompatibility Problem of Intravenous Drugs’ Administration among Intensive Care Unit (ICU) Patients at PKU Muhammadiyah Yogyakarta Hospital |
| title_full_unstemmed | Potential Incompatibility Problem of Intravenous Drugs’ Administration among Intensive Care Unit (ICU) Patients at PKU Muhammadiyah Yogyakarta Hospital |
| title_short | Potential Incompatibility Problem of Intravenous Drugs’ Administration among Intensive Care Unit (ICU) Patients at PKU Muhammadiyah Yogyakarta Hospital |
| title_sort | potential incompatibility problem of intravenous drugs administration among intensive care unit icu patients at pku muhammadiyah yogyakarta hospital |
| topic | incompatibility intravenous intensive care unit |
| url | https://jurnal.ugm.ac.id/jmpf/article/view/40930 |
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