apoE3[K146N/R147W] acts as a dominant negative apoE form that prevents remnant clearance and inhibits the biogenesis of HDL[S]

apoE3[K146N/R147W] acts as a dominant negative apoE form that prevents remnant clearance and inhibits the biogenesis of HDL[S]

The K146N/R147W substitutions in apoE3 were described in patients with a dominant form of type III hyperlipoproteinemia. The effects of these mutations on the in vivo functions of apoE were studied by adenovirus-mediated gene transfer in different mouse models. Expression of the apoE3[K146N/R147W] m...

Full description

Bibliographic Details
Main Authors:	Panagiotis Fotakis, Alexander Vezeridis, Ioannis Dafnis, Angeliki Chroni, Dimitris Kardassis, Vassilis I. Zannis
Format:	Article
Language:	English
Published:	Elsevier 2014-07-01
Series:	Journal of Lipid Research
Subjects:	apolipoprotein E3 dominant type III hyperlipoproteinemia lipoprotein lipase lecithin:cholesterol acyl transferase hypertriglyceridemia recombinant adenovirus
Online Access:	http://www.sciencedirect.com/science/article/pii/S002222752035238X

Similar Items

Molecular etiology of a dominant form of type III hyperlipoproteinemia caused by R142C substitution in apoE4[S]
by: Alexander M. Vezeridis, et al.
Published: (2011-01-01)

Familial chylomicronemia syndrome: case reports of siblings with deletions of the GPIHBP1 gene
by: Ka Young Kim, et al.
Published: (2024-04-01)

Significance of the hydrophobic residues 225–230 of apoA-I for the biogenesis of HDL1[S]
by: Panagiotis Fotakis, et al.
Published: (2013-12-01)

Alteration of negatively charged residues in the 89 to 99 domain of apoA-I affects lipid homeostasis and maturation of HDL[S]
by: Andreas K. Kateifides, et al.
Published: (2011-07-01)

Management of Patients with Type V Hyperlipoproteinemia: An Uncommon Phenotype of Dyslipidemia with Chylomicronemia and Severe Hypertriglyceridemia
by: Ya-Hui Chang, et al.
Published: (2022-12-01)

Exchange of phospholipids between low and high density lipoproteins of squirrel monkeys
by: D. Roger Illingworth, et al.
Published: (1972-03-01)

rHDL modeling and the anchoring mechanism of LCAT activation
by: Tommaso Laurenzi, et al.
Published: (2021-01-01)

Role of the hydrophobic and charged residues in the 218–226 region of apoA-I in the biogenesis of HDL1[S]
by: Panagiotis Fotakis, et al.
Published: (2013-12-01)

Initial interaction of apoA-I with ABCA1 impacts in vivo metabolic fate of nascent HDL*s⃞
by: Anny Mulya, et al.
Published: (2008-11-01)

High-Density Lipoprotein, Lecithin: Cholesterol Acyltransferase, and Atherosclerosis
by: Alice Ossoli, et al.
Published: (2016-06-01)

Evidence for altered positional specificity of LCAT in vivo
by: Papasani V. Subbaiah, et al.
Published: (2004-12-01)

LCAT deficiency in mice is associated with a diminished adrenal glucocorticoid function
by: Menno Hoekstra, et al.
Published: (2013-02-01)

Progression of chronic kidney disease in familial LCAT deficiency: a follow-up of the Italian cohort
by: Chiara Pavanello, et al.
Published: (2020-12-01)

Cholesteryl ester flux from HDL to VLDL-1 is preferentially enhanced in type IIB hyperlipidemia in the postprandial state
by: Maryse Guerin, et al.
Published: (2002-10-01)

Movement of cholesterol in vitro in rat blood and quantitation of the exchange of free cholesterol between plasma and erythrocytes
by: F. d'Hollander, et al.
Published: (1972-11-01)

Effect of apoA-I Mutations in the Capacity of Reconstituted HDL to Promote ABCG1-Mediated Cholesterol Efflux.
by: Georgios Daniil, et al.
Published: (2013-01-01)

Low Plasma Lecithin: Cholesterol Acyltransferase (LCAT) Concentration Predicts Chronic Kidney Disease
by: Andrea Baragetti, et al.
Published: (2020-07-01)

Changes in clinical and blood lipid metabolism parameters in Holstein dairy cattle during the transition period
by: A. Khalphallah, et al.
Published: (2018-12-01)

Activation of lipoprotein lipase by lipoprotein fractions of human serum
by: DENNIS M. BIER, et al.
Published: (1970-11-01)

Metabolism of lysolecithin in vivo: effects of hyperlipemia and atherosclerosis in squirrel monkeys
by: OSCAR W. PORTMAN, et al.
Published: (1970-11-01)

A Novel APOC2 Mutation in a Colombian Patient with Recurrent Hypertriglyceridemic Pancreatitis
by: Pinilla-Monsalve GD, et al.
Published: (2020-03-01)

LDL and HDL enriched in triglyceride promote abnormal cholesterol transport
by: Josephine W. Skeggs, et al.
Published: (2002-08-01)

Impact of serum cholesterol esterification rates on the development of diabetes mellitus in a general population
by: Shin-ichiro Tanaka, et al.
Published: (2018-07-01)

Increased plasma cholesterol esterification by LCAT reduces diet-induced atherosclerosis in SR-BI knockout mice[S]
by: Seth G. Thacker, et al.
Published: (2015-07-01)

LCAT deficiency does not impair amyloid metabolism in APP/PS1 mice[S]
by: Sophie Stukas, et al.
Published: (2014-08-01)

Effect of long chain polyunsaturated fatty acids in the sn-2 position of phosphatidylcholine on the interaction with recombinant high density lipoprotein apolipoprotein A-I
by: Kevin W. Huggins, et al.
Published: (1998-12-01)

LCAT facilitates transacylation of 17β-estradiol in the presence of HDL3 subfraction
by: Anna Höckerstedt, et al.
Published: (2002-03-01)

Measurement of two plasma triglyceride lipases by an immunochemical method: studies in patients with hypertriglyceridemia
by: H Greten, et al.
Published: (1976-05-01)

Remnant-like particle cholesterol and triglyceride levels of hypertriglyceridemic patients in the fed and fasted state
by: Caroline Marcoux, et al.
Published: (2000-09-01)

Effects of natural mutations in lecithin:cholesterol acyltransferase on the enzyme structure and activity
by: F. Peelman, et al.
Published: (1999-01-01)

Conversion of lipid transfer inhibitor protein (apolipoprotein F) to its active form depends on LDL composition
by: Richard E. Morton, et al.
Published: (2011-12-01)

Apolipoprotein A-II regulates HDL stability and affects hepatic lipase association and activity
by: Jonathan Boucher, et al.
Published: (2004-05-01)

Hyperlipidemia in APOE2 transgenic mice is ameliorated by a truncated apoE variant lacking the C-terminal domain
by: Gery Gerritsen, et al.
Published: (2003-02-01)

Plasma and cerebrospinal fluid cholesterol esterification is hampered in Alzheimer’s disease
by: Marta Turri, et al.
Published: (2023-05-01)

Evidence that lipid hydroperoxides inhibit plasma lecithin:cholesterol acyltransferase activity
by: John K. Bielicki, et al.
Published: (1999-05-01)

Postprandial chylomicrons
by: Byung-Hong Chung, et al.
Published: (2004-07-01)

Ghrelin Levels in Male Patients with Hyperlipoproteinemia I, II versus Type 2 Diabetes Mellitus.
by: Salma A. Abbas, et al.
Published: (2014-07-01)

Corrective effects of hepatotoxicity by hepatic Dyrk1a gene delivery in mice with intermediate hyperhomocysteinemia
by: Alizée Latour, et al.
Published: (2015-03-01)

In silico modeling of the dynamics of low density lipoprotein composition via a single plasma sample[S]
by: Martin Jansen, et al.
Published: (2016-05-01)

Functional LCAT deficiency in human apolipoprotein A-I transgenic, SR-BI knockout mice
by: Lee Ji-Young, et al.
Published: (2007-05-01)