Bioinorganic Modulators of Ferroptosis: A Review of Recent Findings
Ferroptosis was first reported as a separate modality of regulated cell death in 2008 and distinguished under its current name in 2012 after it was first induced with erastin. In the following decade, multiple other chemical agents were researched for their pro- or anti-ferroptotic properties. Compl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/4/3634 |
| _version_ | 1797620506119110656 |
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| author | Adrian Bartos Joanna Sikora |
| author_facet | Adrian Bartos Joanna Sikora |
| author_sort | Adrian Bartos |
| collection | DOAJ |
| description | Ferroptosis was first reported as a separate modality of regulated cell death in 2008 and distinguished under its current name in 2012 after it was first induced with erastin. In the following decade, multiple other chemical agents were researched for their pro- or anti-ferroptotic properties. Complex organic structures with numerous aromatic moieties make up the majority of this list. This review fills a more overlooked niche by gathering, outlining and setting out conclusions regarding less prominent cases of ferroptosis induced by bioinorganic compounds and reported on within the last few years. The article contains a short summary of the application of bioinorganic chemicals based on gallium, several chalcogens, transition metals and elements known as human toxicants used for the purpose of evoking ferroptotic cell death in vitro or in vivo. These are used in the form of free ions, salts, chelates, gaseous and solid oxides or nanoparticles. Knowledge of how exactly these modulators promote or inhibit ferroptosis could be beneficial in the context of future therapies aimed against cancer or neurodegenerative diseases, respectively. |
| first_indexed | 2024-03-11T08:43:32Z |
| format | Article |
| id | doaj.art-f57e902d68944b3fb351957c28254634 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T08:43:32Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f57e902d68944b3fb351957c282546342023-11-16T21:02:48ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01244363410.3390/ijms24043634Bioinorganic Modulators of Ferroptosis: A Review of Recent FindingsAdrian Bartos0Joanna Sikora1Department of Bioinorganic Chemistry, Faculty of Pharmacy, Medical University of Lodz, Jana Muszynskiego 1, 90-151 Lodz, PolandDepartment of Bioinorganic Chemistry, Faculty of Pharmacy, Medical University of Lodz, Jana Muszynskiego 1, 90-151 Lodz, PolandFerroptosis was first reported as a separate modality of regulated cell death in 2008 and distinguished under its current name in 2012 after it was first induced with erastin. In the following decade, multiple other chemical agents were researched for their pro- or anti-ferroptotic properties. Complex organic structures with numerous aromatic moieties make up the majority of this list. This review fills a more overlooked niche by gathering, outlining and setting out conclusions regarding less prominent cases of ferroptosis induced by bioinorganic compounds and reported on within the last few years. The article contains a short summary of the application of bioinorganic chemicals based on gallium, several chalcogens, transition metals and elements known as human toxicants used for the purpose of evoking ferroptotic cell death in vitro or in vivo. These are used in the form of free ions, salts, chelates, gaseous and solid oxides or nanoparticles. Knowledge of how exactly these modulators promote or inhibit ferroptosis could be beneficial in the context of future therapies aimed against cancer or neurodegenerative diseases, respectively.https://www.mdpi.com/1422-0067/24/4/3634ferroptosisironinorganicbioinorganicinducerinhibitor |
| spellingShingle | Adrian Bartos Joanna Sikora Bioinorganic Modulators of Ferroptosis: A Review of Recent Findings International Journal of Molecular Sciences ferroptosis iron inorganic bioinorganic inducer inhibitor |
| title | Bioinorganic Modulators of Ferroptosis: A Review of Recent Findings |
| title_full | Bioinorganic Modulators of Ferroptosis: A Review of Recent Findings |
| title_fullStr | Bioinorganic Modulators of Ferroptosis: A Review of Recent Findings |
| title_full_unstemmed | Bioinorganic Modulators of Ferroptosis: A Review of Recent Findings |
| title_short | Bioinorganic Modulators of Ferroptosis: A Review of Recent Findings |
| title_sort | bioinorganic modulators of ferroptosis a review of recent findings |
| topic | ferroptosis iron inorganic bioinorganic inducer inhibitor |
| url | https://www.mdpi.com/1422-0067/24/4/3634 |
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