P2X1: a unique platelet receptor with a key role in thromboinflammation
Thromboinflammation involves complex interactions between actors of inflammation and immunity and components of the hemostatic system, which are elicited upon infection or tissue injury. In this context, the interplay between platelets and innate immune cells has been intensively investigated. The A...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-10-01
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| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2021.1902972 |
| _version_ | 1797684173280903168 |
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| author | Cécile Oury Odile Wéra |
| author_facet | Cécile Oury Odile Wéra |
| author_sort | Cécile Oury |
| collection | DOAJ |
| description | Thromboinflammation involves complex interactions between actors of inflammation and immunity and components of the hemostatic system, which are elicited upon infection or tissue injury. In this context, the interplay between platelets and innate immune cells has been intensively investigated. The ATP-gated P2X1 ion channel, expressed on both platelets and neutrophils is of particular interest. On platelets, this ion channel contributes to platelet activation and thrombosis, especially under high shear stress conditions of small arteries, whereas on neutrophils, it is involved in chemotaxis and in mitigating the activation of circulating cells. In vitro studies indicate that it may also be implicated in platelet-dependent immune responses during bacterial infection. More recently, in a mouse model of intestinal epithelial barrier disruption causing systemic inflammation, it has been reported that neutrophil P2X1 ion channel could play a protective role against exaggerated inflammation-associated thrombosis. This review will focus on this unique role of the ATP-gated P2X1 ion channel in thromboinflammation, highlighting possible implications and pointing to the need for further investigation of the role of P2X1 ion channels in the interplay between platelets and neutrophils during thrombus formation under various sterile or infectious inflammatory settings and in distinct vascular beds. |
| first_indexed | 2024-03-12T00:25:43Z |
| format | Article |
| id | doaj.art-f57f602b291442898e204071c8b52320 |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:25:43Z |
| publishDate | 2021-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-f57f602b291442898e204071c8b523202023-09-15T10:38:09ZengTaylor & Francis GroupPlatelets0953-71041369-16352021-10-0132790290810.1080/09537104.2021.19029721902972P2X1: a unique platelet receptor with a key role in thromboinflammationCécile Oury0Odile Wéra1University of LiègeUniversity of LiègeThromboinflammation involves complex interactions between actors of inflammation and immunity and components of the hemostatic system, which are elicited upon infection or tissue injury. In this context, the interplay between platelets and innate immune cells has been intensively investigated. The ATP-gated P2X1 ion channel, expressed on both platelets and neutrophils is of particular interest. On platelets, this ion channel contributes to platelet activation and thrombosis, especially under high shear stress conditions of small arteries, whereas on neutrophils, it is involved in chemotaxis and in mitigating the activation of circulating cells. In vitro studies indicate that it may also be implicated in platelet-dependent immune responses during bacterial infection. More recently, in a mouse model of intestinal epithelial barrier disruption causing systemic inflammation, it has been reported that neutrophil P2X1 ion channel could play a protective role against exaggerated inflammation-associated thrombosis. This review will focus on this unique role of the ATP-gated P2X1 ion channel in thromboinflammation, highlighting possible implications and pointing to the need for further investigation of the role of P2X1 ion channels in the interplay between platelets and neutrophils during thrombus formation under various sterile or infectious inflammatory settings and in distinct vascular beds.http://dx.doi.org/10.1080/09537104.2021.1902972neutrophilsp2x1 ion channelplateletsthromboinflammation |
| spellingShingle | Cécile Oury Odile Wéra P2X1: a unique platelet receptor with a key role in thromboinflammation Platelets neutrophils p2x1 ion channel platelets thromboinflammation |
| title | P2X1: a unique platelet receptor with a key role in thromboinflammation |
| title_full | P2X1: a unique platelet receptor with a key role in thromboinflammation |
| title_fullStr | P2X1: a unique platelet receptor with a key role in thromboinflammation |
| title_full_unstemmed | P2X1: a unique platelet receptor with a key role in thromboinflammation |
| title_short | P2X1: a unique platelet receptor with a key role in thromboinflammation |
| title_sort | p2x1 a unique platelet receptor with a key role in thromboinflammation |
| topic | neutrophils p2x1 ion channel platelets thromboinflammation |
| url | http://dx.doi.org/10.1080/09537104.2021.1902972 |
| work_keys_str_mv | AT cecileoury p2x1auniqueplateletreceptorwithakeyroleinthromboinflammation AT odilewera p2x1auniqueplateletreceptorwithakeyroleinthromboinflammation |