3D Cell Spheroids as a Tool for Evaluating the Effectiveness of Carbon Nanotubes as a Drug Delivery and Photothermal Therapy Agents
Cell spheroids (CSs) are three-dimensional models in vitro that have a microenvironment similar to tissues. Such three-dimensional cellular structures are of great interest in the field of nano biomedical research, as they can simulate information about the characteristics of nanoparticles (NPs) by...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | C |
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| Online Access: | https://www.mdpi.com/2311-5629/8/4/56 |
| _version_ | 1797461049628164096 |
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| author | Roman A. Anisimov Dmitry A. Gorin Anatolii A. Abalymov |
| author_facet | Roman A. Anisimov Dmitry A. Gorin Anatolii A. Abalymov |
| author_sort | Roman A. Anisimov |
| collection | DOAJ |
| description | Cell spheroids (CSs) are three-dimensional models in vitro that have a microenvironment similar to tissues. Such three-dimensional cellular structures are of great interest in the field of nano biomedical research, as they can simulate information about the characteristics of nanoparticles (NPs) by avoiding the use of laboratory animals. Due to the development of areas such as bioethics and tissue engineering, it is expected that the use of such 3D cell structures will become an even more valuable tool in the hands of researchers. We present an overview of carbon nanotubes (CNTs) research on CSs in order to determine the mechanism of their incorporation into CSs, drug delivery, and photothermal therapy. We will look at such areas as the application of CNTs for medical purposes, the advantages of spheroids over classical 2D cell culture, the ways in which CNTs pass into the intercellular space, and the ways in which they are absorbed by cells in a three-dimensional environment, the use of the spheroid model for such studies as drug delivery and photothermal therapy. Thus, CSs are suitable models for obtaining additional information on the required properties of CNTs in their application in nanobiomedicine. |
| first_indexed | 2024-03-09T17:14:52Z |
| format | Article |
| id | doaj.art-f581038c38bb464bad940889852a1ba0 |
| institution | Directory Open Access Journal |
| issn | 2311-5629 |
| language | English |
| last_indexed | 2024-03-09T17:14:52Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | C |
| spelling | doaj.art-f581038c38bb464bad940889852a1ba02023-11-24T13:49:17ZengMDPI AGC2311-56292022-10-01845610.3390/c80400563D Cell Spheroids as a Tool for Evaluating the Effectiveness of Carbon Nanotubes as a Drug Delivery and Photothermal Therapy AgentsRoman A. Anisimov0Dmitry A. Gorin1Anatolii A. Abalymov2Science Medical Center, Saratov State University, 410012 Saratov, RussiaCenter for Photonic Science and Engineering, Skolkovo Institute of Science and Technology, 121205 Moscow, RussiaScience Medical Center, Saratov State University, 410012 Saratov, RussiaCell spheroids (CSs) are three-dimensional models in vitro that have a microenvironment similar to tissues. Such three-dimensional cellular structures are of great interest in the field of nano biomedical research, as they can simulate information about the characteristics of nanoparticles (NPs) by avoiding the use of laboratory animals. Due to the development of areas such as bioethics and tissue engineering, it is expected that the use of such 3D cell structures will become an even more valuable tool in the hands of researchers. We present an overview of carbon nanotubes (CNTs) research on CSs in order to determine the mechanism of their incorporation into CSs, drug delivery, and photothermal therapy. We will look at such areas as the application of CNTs for medical purposes, the advantages of spheroids over classical 2D cell culture, the ways in which CNTs pass into the intercellular space, and the ways in which they are absorbed by cells in a three-dimensional environment, the use of the spheroid model for such studies as drug delivery and photothermal therapy. Thus, CSs are suitable models for obtaining additional information on the required properties of CNTs in their application in nanobiomedicine.https://www.mdpi.com/2311-5629/8/4/56cell spheroidscarbon nanotubesCNTsnanomedicinespenetration |
| spellingShingle | Roman A. Anisimov Dmitry A. Gorin Anatolii A. Abalymov 3D Cell Spheroids as a Tool for Evaluating the Effectiveness of Carbon Nanotubes as a Drug Delivery and Photothermal Therapy Agents C cell spheroids carbon nanotubes CNTs nanomedicines penetration |
| title | 3D Cell Spheroids as a Tool for Evaluating the Effectiveness of Carbon Nanotubes as a Drug Delivery and Photothermal Therapy Agents |
| title_full | 3D Cell Spheroids as a Tool for Evaluating the Effectiveness of Carbon Nanotubes as a Drug Delivery and Photothermal Therapy Agents |
| title_fullStr | 3D Cell Spheroids as a Tool for Evaluating the Effectiveness of Carbon Nanotubes as a Drug Delivery and Photothermal Therapy Agents |
| title_full_unstemmed | 3D Cell Spheroids as a Tool for Evaluating the Effectiveness of Carbon Nanotubes as a Drug Delivery and Photothermal Therapy Agents |
| title_short | 3D Cell Spheroids as a Tool for Evaluating the Effectiveness of Carbon Nanotubes as a Drug Delivery and Photothermal Therapy Agents |
| title_sort | 3d cell spheroids as a tool for evaluating the effectiveness of carbon nanotubes as a drug delivery and photothermal therapy agents |
| topic | cell spheroids carbon nanotubes CNTs nanomedicines penetration |
| url | https://www.mdpi.com/2311-5629/8/4/56 |
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