pH-responsive theranostic nanoplatform of ferrite and ceria co-engineered nanoparticles for anti-inflammatory
Multiple component integration to achieve both therapy and diagnosis in a single theranostic nanosystem has aroused great research interest in the medical investigator. This study aimed to construct a novel theranostic nanoplatform ferrite and ceria co-engineered mesoporous silica nanoparticles (Fe/...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.983677/full |
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| author | Yuanyao Dou Yuanyao Dou Yimin Zhang Caiyu Lin Rui Han Yubo Wang Di Wu Jie Zheng Conghua Lu Liling Tang Yong He |
| author_facet | Yuanyao Dou Yuanyao Dou Yimin Zhang Caiyu Lin Rui Han Yubo Wang Di Wu Jie Zheng Conghua Lu Liling Tang Yong He |
| author_sort | Yuanyao Dou |
| collection | DOAJ |
| description | Multiple component integration to achieve both therapy and diagnosis in a single theranostic nanosystem has aroused great research interest in the medical investigator. This study aimed to construct a novel theranostic nanoplatform ferrite and ceria co-engineered mesoporous silica nanoparticles (Fe/Ce-MSN) antioxidant agent though a facile metal Fe/Ce-codoping approach in the MSN framework. The resulted Fe3+-incorporated ceria-based MSN nanoparticles possessing a higher Ce3+-to-Ce4+ ratio than those revealed by ceria-only nanoparticles. The as-prepared Fe/Ce-MSN nanoparticles exhibited an excellent efficiency in scavenging reactive oxygen species (ROS), which is attributed to improving the superoxide dismutase (SOD) mimetics activity by increasing Ce3+ content and maintaining a higher activity of catalase (CAT) mimetics via including ferrite ion in nanoparticles. The fast Fe/Ce-MSN biodegradation, which is sensitive to the mild acidic microenvironment of inflammation, can accelerate Fe/Ce ion release, and the freed Fe ions enhanced T2-weighted magnetic resonance imaging in the inflammation site. PEGylated Fe/Ce-MSN nanoparticles in vitro cell models significantly attenuated ROS-induced inflammation, oxidative stress, and apoptosis in macrophages by scavenging overproduced intracellular ROS. More importantly, Fe/Ce-MSN-PEG NPs exhibited significant anti-inflammatory effects by inhibiting lipopolysaccharide (LPS)-induced expression of tumor necrosis factor-α (TNF-α) and interleukin-1 beta (IL-1β) levels in vitro. Additionally, it can promote the macrophages polarization of pro-inflammatory M1 phenotype towards an anti-inflammatory M2 phenotype. Thus, the novel pH-responsive theranostic nanoplatform shows great promise for inflammation and oxidative stress-associated disease treatment. |
| first_indexed | 2024-04-12T04:56:24Z |
| format | Article |
| id | doaj.art-f58394e3469e4aa58810278711e8e7b8 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-12T04:56:24Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-f58394e3469e4aa58810278711e8e7b82022-12-22T03:47:08ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-09-011010.3389/fbioe.2022.983677983677pH-responsive theranostic nanoplatform of ferrite and ceria co-engineered nanoparticles for anti-inflammatoryYuanyao Dou0Yuanyao Dou1Yimin Zhang2Caiyu Lin3Rui Han4Yubo Wang5Di Wu6Jie Zheng7Conghua Lu8Liling Tang9Yong He10Department of Respiratory Medicine, Daping Hospital, Army Medical University, Chongqing, ChinaKey Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, ChinaDepartment of Respiratory Medicine, Daping Hospital, Army Medical University, Chongqing, ChinaDepartment of Respiratory Medicine, Daping Hospital, Army Medical University, Chongqing, ChinaDepartment of Respiratory Medicine, Daping Hospital, Army Medical University, Chongqing, ChinaDepartment of Respiratory Medicine, Daping Hospital, Army Medical University, Chongqing, ChinaDepartment of Respiratory Medicine, Daping Hospital, Army Medical University, Chongqing, ChinaDepartment of Respiratory Medicine, Daping Hospital, Army Medical University, Chongqing, ChinaDepartment of Respiratory Medicine, Daping Hospital, Army Medical University, Chongqing, ChinaKey Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, ChinaDepartment of Respiratory Medicine, Daping Hospital, Army Medical University, Chongqing, ChinaMultiple component integration to achieve both therapy and diagnosis in a single theranostic nanosystem has aroused great research interest in the medical investigator. This study aimed to construct a novel theranostic nanoplatform ferrite and ceria co-engineered mesoporous silica nanoparticles (Fe/Ce-MSN) antioxidant agent though a facile metal Fe/Ce-codoping approach in the MSN framework. The resulted Fe3+-incorporated ceria-based MSN nanoparticles possessing a higher Ce3+-to-Ce4+ ratio than those revealed by ceria-only nanoparticles. The as-prepared Fe/Ce-MSN nanoparticles exhibited an excellent efficiency in scavenging reactive oxygen species (ROS), which is attributed to improving the superoxide dismutase (SOD) mimetics activity by increasing Ce3+ content and maintaining a higher activity of catalase (CAT) mimetics via including ferrite ion in nanoparticles. The fast Fe/Ce-MSN biodegradation, which is sensitive to the mild acidic microenvironment of inflammation, can accelerate Fe/Ce ion release, and the freed Fe ions enhanced T2-weighted magnetic resonance imaging in the inflammation site. PEGylated Fe/Ce-MSN nanoparticles in vitro cell models significantly attenuated ROS-induced inflammation, oxidative stress, and apoptosis in macrophages by scavenging overproduced intracellular ROS. More importantly, Fe/Ce-MSN-PEG NPs exhibited significant anti-inflammatory effects by inhibiting lipopolysaccharide (LPS)-induced expression of tumor necrosis factor-α (TNF-α) and interleukin-1 beta (IL-1β) levels in vitro. Additionally, it can promote the macrophages polarization of pro-inflammatory M1 phenotype towards an anti-inflammatory M2 phenotype. Thus, the novel pH-responsive theranostic nanoplatform shows great promise for inflammation and oxidative stress-associated disease treatment.https://www.frontiersin.org/articles/10.3389/fbioe.2022.983677/fullreactive oxygen species (ROS)Fe/Ce-MSN-PEG NPstheranostic nanoplatformanti-oxidative stressanti-inflammatory |
| spellingShingle | Yuanyao Dou Yuanyao Dou Yimin Zhang Caiyu Lin Rui Han Yubo Wang Di Wu Jie Zheng Conghua Lu Liling Tang Yong He pH-responsive theranostic nanoplatform of ferrite and ceria co-engineered nanoparticles for anti-inflammatory Frontiers in Bioengineering and Biotechnology reactive oxygen species (ROS) Fe/Ce-MSN-PEG NPs theranostic nanoplatform anti-oxidative stress anti-inflammatory |
| title | pH-responsive theranostic nanoplatform of ferrite and ceria co-engineered nanoparticles for anti-inflammatory |
| title_full | pH-responsive theranostic nanoplatform of ferrite and ceria co-engineered nanoparticles for anti-inflammatory |
| title_fullStr | pH-responsive theranostic nanoplatform of ferrite and ceria co-engineered nanoparticles for anti-inflammatory |
| title_full_unstemmed | pH-responsive theranostic nanoplatform of ferrite and ceria co-engineered nanoparticles for anti-inflammatory |
| title_short | pH-responsive theranostic nanoplatform of ferrite and ceria co-engineered nanoparticles for anti-inflammatory |
| title_sort | ph responsive theranostic nanoplatform of ferrite and ceria co engineered nanoparticles for anti inflammatory |
| topic | reactive oxygen species (ROS) Fe/Ce-MSN-PEG NPs theranostic nanoplatform anti-oxidative stress anti-inflammatory |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.983677/full |
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