Lp(a) does not affect intima media thickness in hypercholesterolemic children –a retrospective cross sectional study
Purpose: Combined hyperlipidaemia results in premature atherosclerosis and a high burden of cardiovascular morbidity and mortality. Early identification of highly affected subjects within this population is of utmost importance to enable informed treatment decisions. The measurement of intima media...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Atherosclerosis Plus |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667089522000578 |
| _version_ | 1797866947983966208 |
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| author | Oliver Helk Andreas Böck Claudia Stefanutti Kurt Widhalm |
| author_facet | Oliver Helk Andreas Böck Claudia Stefanutti Kurt Widhalm |
| author_sort | Oliver Helk |
| collection | DOAJ |
| description | Purpose: Combined hyperlipidaemia results in premature atherosclerosis and a high burden of cardiovascular morbidity and mortality. Early identification of highly affected subjects within this population is of utmost importance to enable informed treatment decisions. The measurement of intima media thickness (IMT) is a readily available, non-invasive method to investigate evidence of early atherosclerosis. To assess the usefulness of this method in pediatric subjects with hypercholesterolemia, we here examined a possible interaction of LDL-C and Lp(a) on IMT. Methods: Blood lipids (Lp(a), LDL-cholesterol, total cholesterol, triglycerides, high density lipoprotein (HDL) -cholesterol, apolipoprotein A1, apolipoprotein B), anthropometric parameters (age, height, weight, body mass index (BMI)) and possibly existing early evidence of atherosclerotic lesions measured by intima media thickness (IMT zscore).as a surrogate parameter was examined retrospectively in 113 children and adolescents (aged 1–18 years) with elevated Lp(a) and/or LDL-cholesterol (Lp(a) > 30 mg/dL, LDL>130 mg/dL). Furthermore, we compared hsCRP levels between groups. Results: There were no significant differences in IMT Zscore or hsCRP between groups. Regression analysis did not reveal a statistically significant interaction between Lp(a) and LDL-C. Conclusions: At the age of 6–18 years, we found no significant differences in early markers of atherosclerosis between subjects with high Lp(a)- and/or high LDL-cholesterol with no detectable synergistic effects between the two lipoproteins. |
| first_indexed | 2024-04-09T23:32:26Z |
| format | Article |
| id | doaj.art-f584f13c7d0c43ed9fe24cbf4b128952 |
| institution | Directory Open Access Journal |
| issn | 2667-0895 |
| language | English |
| last_indexed | 2024-04-09T23:32:26Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Atherosclerosis Plus |
| spelling | doaj.art-f584f13c7d0c43ed9fe24cbf4b1289522023-03-21T04:17:16ZengElsevierAtherosclerosis Plus2667-08952023-03-015117Lp(a) does not affect intima media thickness in hypercholesterolemic children –a retrospective cross sectional studyOliver Helk0Andreas Böck1Claudia Stefanutti2Kurt Widhalm3Department of Nephrology and Dialysis, Medical University of Vienna, AustriaUniversity Department for Paediatrics and Adolescent Medicine, Medical University of Vienna, AustriaExtracorporeal Therapeutic Techniques, Lipid Clinic and Atherosclerosis Prevention Centre, Department of Molecular Medicine and Department of Immunohematology and Transfusion Medicine, ‘Sapienza’ University of Rome, ItalyUniversity Department for Paediatrics and Adolescent Medicine, Medical University of Vienna, Austria; Corresponding author. Alserstraße 14a/5, 1090, Vienna, Austria.Purpose: Combined hyperlipidaemia results in premature atherosclerosis and a high burden of cardiovascular morbidity and mortality. Early identification of highly affected subjects within this population is of utmost importance to enable informed treatment decisions. The measurement of intima media thickness (IMT) is a readily available, non-invasive method to investigate evidence of early atherosclerosis. To assess the usefulness of this method in pediatric subjects with hypercholesterolemia, we here examined a possible interaction of LDL-C and Lp(a) on IMT. Methods: Blood lipids (Lp(a), LDL-cholesterol, total cholesterol, triglycerides, high density lipoprotein (HDL) -cholesterol, apolipoprotein A1, apolipoprotein B), anthropometric parameters (age, height, weight, body mass index (BMI)) and possibly existing early evidence of atherosclerotic lesions measured by intima media thickness (IMT zscore).as a surrogate parameter was examined retrospectively in 113 children and adolescents (aged 1–18 years) with elevated Lp(a) and/or LDL-cholesterol (Lp(a) > 30 mg/dL, LDL>130 mg/dL). Furthermore, we compared hsCRP levels between groups. Results: There were no significant differences in IMT Zscore or hsCRP between groups. Regression analysis did not reveal a statistically significant interaction between Lp(a) and LDL-C. Conclusions: At the age of 6–18 years, we found no significant differences in early markers of atherosclerosis between subjects with high Lp(a)- and/or high LDL-cholesterol with no detectable synergistic effects between the two lipoproteins.http://www.sciencedirect.com/science/article/pii/S2667089522000578 |
| spellingShingle | Oliver Helk Andreas Böck Claudia Stefanutti Kurt Widhalm Lp(a) does not affect intima media thickness in hypercholesterolemic children –a retrospective cross sectional study Atherosclerosis Plus |
| title | Lp(a) does not affect intima media thickness in hypercholesterolemic children –a retrospective cross sectional study |
| title_full | Lp(a) does not affect intima media thickness in hypercholesterolemic children –a retrospective cross sectional study |
| title_fullStr | Lp(a) does not affect intima media thickness in hypercholesterolemic children –a retrospective cross sectional study |
| title_full_unstemmed | Lp(a) does not affect intima media thickness in hypercholesterolemic children –a retrospective cross sectional study |
| title_short | Lp(a) does not affect intima media thickness in hypercholesterolemic children –a retrospective cross sectional study |
| title_sort | lp a does not affect intima media thickness in hypercholesterolemic children a retrospective cross sectional study |
| url | http://www.sciencedirect.com/science/article/pii/S2667089522000578 |
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