Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling
Nonalcoholic steatohepatitis (NASH) and dietary cholesterol are risk factors for hepatocellular carcinoma (HCC). Here, the authors utilise mouse models to show that dietary cholesterol induces NASH by deregulating genes involved in metabolism, inflammation and calcium signaling to induce NASH-HCC.
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06931-6 |
| _version_ | 1818341766848315392 |
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| author | Jessie Qiaoyi Liang Narcissus Teoh Lixia Xu Sharon Pok Xiangchun Li Eagle S. H. Chu Jonathan Chiu Ling Dong Evi Arfianti W. Geoffrey Haigh Matthew M. Yeh George N. Ioannou Joseph J. Y. Sung Geoffrey Farrell Jun Yu |
| author_facet | Jessie Qiaoyi Liang Narcissus Teoh Lixia Xu Sharon Pok Xiangchun Li Eagle S. H. Chu Jonathan Chiu Ling Dong Evi Arfianti W. Geoffrey Haigh Matthew M. Yeh George N. Ioannou Joseph J. Y. Sung Geoffrey Farrell Jun Yu |
| author_sort | Jessie Qiaoyi Liang |
| collection | DOAJ |
| description | Nonalcoholic steatohepatitis (NASH) and dietary cholesterol are risk factors for hepatocellular carcinoma (HCC). Here, the authors utilise mouse models to show that dietary cholesterol induces NASH by deregulating genes involved in metabolism, inflammation and calcium signaling to induce NASH-HCC. |
| first_indexed | 2024-12-13T16:04:01Z |
| format | Article |
| id | doaj.art-f586a8b5cf4f4dbbb56141228ef1c3be |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:04:01Z |
| publishDate | 2018-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f586a8b5cf4f4dbbb56141228ef1c3be2022-12-21T23:39:05ZengNature PortfolioNature Communications2041-17232018-10-019111310.1038/s41467-018-06931-6Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signalingJessie Qiaoyi Liang0Narcissus Teoh1Lixia Xu2Sharon Pok3Xiangchun Li4Eagle S. H. Chu5Jonathan Chiu6Ling Dong7Evi Arfianti8W. Geoffrey Haigh9Matthew M. Yeh10George N. Ioannou11Joseph J. Y. Sung12Geoffrey Farrell13Jun Yu14Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Institute of Digestive Disease and Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong KongLiver Research Group, Australian National University Medical School at the Canberra HospitalDepartment of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Institute of Digestive Disease and Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong KongLiver Research Group, Australian National University Medical School at the Canberra HospitalDepartment of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Institute of Digestive Disease and Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong KongDepartment of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Institute of Digestive Disease and Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong KongDepartment of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Institute of Digestive Disease and Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong KongDepartment of Gastroenterology and Hepatology, Zhongshan Hospital of Fudan UniversityLiver Research Group, Australian National University Medical School at the Canberra HospitalDepartment of Gastroenterology and Hepatology, Veterans Affairs Puget Sound Health Care System and University of WashingtonDepartment of Pathology, University of Washington School of MedicineDepartment of Gastroenterology and Hepatology, Veterans Affairs Puget Sound Health Care System and University of WashingtonDepartment of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Institute of Digestive Disease and Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong KongLiver Research Group, Australian National University Medical School at the Canberra HospitalDepartment of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Institute of Digestive Disease and Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong KongNonalcoholic steatohepatitis (NASH) and dietary cholesterol are risk factors for hepatocellular carcinoma (HCC). Here, the authors utilise mouse models to show that dietary cholesterol induces NASH by deregulating genes involved in metabolism, inflammation and calcium signaling to induce NASH-HCC.https://doi.org/10.1038/s41467-018-06931-6 |
| spellingShingle | Jessie Qiaoyi Liang Narcissus Teoh Lixia Xu Sharon Pok Xiangchun Li Eagle S. H. Chu Jonathan Chiu Ling Dong Evi Arfianti W. Geoffrey Haigh Matthew M. Yeh George N. Ioannou Joseph J. Y. Sung Geoffrey Farrell Jun Yu Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling Nature Communications |
| title | Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling |
| title_full | Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling |
| title_fullStr | Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling |
| title_full_unstemmed | Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling |
| title_short | Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling |
| title_sort | dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling |
| url | https://doi.org/10.1038/s41467-018-06931-6 |
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