Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling

Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling

Nonalcoholic steatohepatitis (NASH) and dietary cholesterol are risk factors for hepatocellular carcinoma (HCC). Here, the authors utilise mouse models to show that dietary cholesterol induces NASH by deregulating genes involved in metabolism, inflammation and calcium signaling to induce NASH-HCC.

Bibliographic Details
Main Authors: Jessie Qiaoyi Liang, Narcissus Teoh, Lixia Xu, Sharon Pok, Xiangchun Li, Eagle S. H. Chu, Jonathan Chiu, Ling Dong, Evi Arfianti, W. Geoffrey Haigh, Matthew M. Yeh, George N. Ioannou, Joseph J. Y. Sung, Geoffrey Farrell, Jun Yu
Format: Article
Language:English
Published: Nature Portfolio 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06931-6

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