Hypersialylation and multiple myeloma
There is growing recognition of the importance of sialylation as a critical post translational modification in cancer. In this article we review the role of increased cell surface sialylation (hypersialylation) in Multiple Myeloma as it relates to cellular trafficking and immune evasion. Knowledge o...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-02-01
|
| Series: | Frontiers in Hematology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/frhem.2024.1360149/full |
| _version_ | 1797302909564616704 |
|---|---|
| author | Michael O’Dwyer Michael O’Dwyer Siobhan Glavey Roisin McAvera Alessandro Natoni Aideen E. Ryan Aideen E. Ryan |
| author_facet | Michael O’Dwyer Michael O’Dwyer Siobhan Glavey Roisin McAvera Alessandro Natoni Aideen E. Ryan Aideen E. Ryan |
| author_sort | Michael O’Dwyer |
| collection | DOAJ |
| description | There is growing recognition of the importance of sialylation as a critical post translational modification in cancer. In this article we review the role of increased cell surface sialylation (hypersialylation) in Multiple Myeloma as it relates to cellular trafficking and immune evasion. Knowledge of the specific effects of sialic acid on cell trafficking machinery and modulation of immune cell interactions will identify opportunities for therapeutic interventions. The available evidence indicates that hypersialylation facilitates disease progression and negatively impacts on response to treatment and overall survival. Further research is required to fully elucidate the mechanisms through which hypersialylation influences disease biology and therapy resistance with the ultimate goal of developing new treatment approaches to improve the outcomes of patients with Multiple Myeloma. |
| first_indexed | 2024-03-07T23:44:45Z |
| format | Article |
| id | doaj.art-f586f68ca55c465981fdf07ac019f9a2 |
| institution | Directory Open Access Journal |
| issn | 2813-3935 |
| language | English |
| last_indexed | 2024-03-07T23:44:45Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Hematology |
| spelling | doaj.art-f586f68ca55c465981fdf07ac019f9a22024-02-19T16:48:51ZengFrontiers Media S.A.Frontiers in Hematology2813-39352024-02-01310.3389/frhem.2024.13601491360149Hypersialylation and multiple myelomaMichael O’Dwyer0Michael O’Dwyer1Siobhan Glavey2Roisin McAvera3Alessandro Natoni4Aideen E. Ryan5Aideen E. Ryan6Department of Hematology, School of Medicine, University of Galway, Galway, IrelandLambe Institute for Translational Research, School of Medicine, College of Medicine Nursing and Health Sciences, University of Galway, Galway, IrelandMultiple Myeloma Research Group, Department of Pathology, Royal College of Surgeons in Ireland, Department of Pathology, Beaumont Hospital, Dublin, IrelandMultiple Myeloma Research Group, Department of Pathology, Royal College of Surgeons in Ireland, Department of Pathology, Beaumont Hospital, Dublin, IrelandHematology, Department of Translational and Precision Medicine, Sapienza University, Rome, ItalyLambe Institute for Translational Research, School of Medicine, College of Medicine Nursing and Health Sciences, University of Galway, Galway, IrelandDiscipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, IrelandThere is growing recognition of the importance of sialylation as a critical post translational modification in cancer. In this article we review the role of increased cell surface sialylation (hypersialylation) in Multiple Myeloma as it relates to cellular trafficking and immune evasion. Knowledge of the specific effects of sialic acid on cell trafficking machinery and modulation of immune cell interactions will identify opportunities for therapeutic interventions. The available evidence indicates that hypersialylation facilitates disease progression and negatively impacts on response to treatment and overall survival. Further research is required to fully elucidate the mechanisms through which hypersialylation influences disease biology and therapy resistance with the ultimate goal of developing new treatment approaches to improve the outcomes of patients with Multiple Myeloma.https://www.frontiersin.org/articles/10.3389/frhem.2024.1360149/fullmultiple myelomaglycosylationsialic acidselectinSiglecimmune evasion |
| spellingShingle | Michael O’Dwyer Michael O’Dwyer Siobhan Glavey Roisin McAvera Alessandro Natoni Aideen E. Ryan Aideen E. Ryan Hypersialylation and multiple myeloma Frontiers in Hematology multiple myeloma glycosylation sialic acid selectin Siglec immune evasion |
| title | Hypersialylation and multiple myeloma |
| title_full | Hypersialylation and multiple myeloma |
| title_fullStr | Hypersialylation and multiple myeloma |
| title_full_unstemmed | Hypersialylation and multiple myeloma |
| title_short | Hypersialylation and multiple myeloma |
| title_sort | hypersialylation and multiple myeloma |
| topic | multiple myeloma glycosylation sialic acid selectin Siglec immune evasion |
| url | https://www.frontiersin.org/articles/10.3389/frhem.2024.1360149/full |
| work_keys_str_mv | AT michaelodwyer hypersialylationandmultiplemyeloma AT michaelodwyer hypersialylationandmultiplemyeloma AT siobhanglavey hypersialylationandmultiplemyeloma AT roisinmcavera hypersialylationandmultiplemyeloma AT alessandronatoni hypersialylationandmultiplemyeloma AT aideeneryan hypersialylationandmultiplemyeloma AT aideeneryan hypersialylationandmultiplemyeloma |