METTL3-regulated m6A modification impairs the decidualization of endometrial stromal cells by regulating YTHDF2-mediated degradation of FOXO1 mRNA in endometriosis-related infertility

METTL3-regulated m6A modification impairs the decidualization of endometrial stromal cells by regulating YTHDF2-mediated degradation of FOXO1 mRNA in endometriosis-related infertility

Abstract Background Endometriosis-related infertility is a common worldwide reproductive health concern. Despite ongoing research, the causes of infertility remain unclear. Evidence suggests that epigenetic regulation is crucial in reproduction. However, the role of N6-methyladenosine (m6A) modifica...

Full description

Bibliographic Details
Main Authors:	Xiaoou Li, Jie Jin, Xuefeng Long, Ruiwen Weng, Wenqian Xiong, Jiaxin Liang, Junjun Liu, Jingwen Sun, Xueqin Cai, Ling Zhang, Yi Liu
Format:	Article
Language:	English
Published:	BMC 2023-10-01
Series:	Reproductive Biology and Endocrinology
Subjects:	Decidualization Endometriosis Infertility N6-methyladenosine Methyltransferase-like 3 Forkhead box O1
Online Access:	https://doi.org/10.1186/s12958-023-01151-0

Similar Items

METTL3 Mediates Epithelial–Mesenchymal Transition by Modulating FOXO1 mRNA N6‐Methyladenosine‐Dependent YTHDF2 Binding: A Novel Mechanism of Radiation‐Induced Lung Injury
by: Yang Feng, et al.
Published: (2023-06-01)

Mechanism of METTL14-mediated ERα m6A regulation of endometrial cancer metastasis
by: ZHAO Manying, WU Dongyue, DU Ruiting, YIN Lu, LUO Yulu
Published: (2023-03-01)

METTL3 facilitates immunosurveillance by inhibiting YTHDF2-mediated NLRC5 mRNA degradation in endometrial cancer
by: Lei Zhan, et al.
Published: (2023-04-01)

WTAP promotes proliferation and aerobic glycolysis via regulating m6A modification of BMI1 mRNA
by: DIAO Xinfeng, LI Xinmao, HOU Liang, WEI Zhixuan
Published: (2023-07-01)

MEF2C Expression Is Regulated by the Post-transcriptional Activation of the METTL3-m6A-YTHDF1 Axis in Myoblast Differentiation
by: Xinran Yang, et al.
Published: (2022-04-01)

The involvement of RNA N6‐methyladenosine and histone methylation modification in decidualization and endometriosis‐associated infertility
by: Xiang Lin, et al.
Published: (2024-02-01)

Sequencing, Physiological Regulation, and Representative Disease Research Progress of RNA m<sup>6</sup>A Modification
by: Xiaoqian Chen, et al.
Published: (2024-03-01)

YTHDF1 Promotes Bladder Cancer Cell Proliferation via the METTL3/YTHDF1–RPN2–PI3K/AKT/mTOR Axis
by: Junlong Zhu, et al.
Published: (2023-04-01)

METTL16 promotes hepatocellular carcinoma progression through downregulating RAB11B-AS1 in an m6A-dependent manner
by: Yun-zhang Dai, et al.
Published: (2022-05-01)

Methyltransferase-like (METTL) homologues participate in Nicotiana benthamiana antiviral responses
by: Jianying Yue, et al.
Published: (2023-12-01)

PGRMC1 Regulates Cellular Senescence via Modulating FOXO1 Expression in Decidualizing Endometrial Stromal Cells
by: Atsuya Tsuru, et al.
Published: (2022-07-01)

MTA, an RNA m<sup>6</sup>A Methyltransferase, Enhances Drought Tolerance by Regulating the Development of Trichomes and Roots in Poplar
by: Liang Lu, et al.
Published: (2020-04-01)

The Identification of Critical m6A RNA Methylation Regulators as Malignant Prognosis Factors in Prostate Adenocarcinoma
by: Jiaju Xu, et al.
Published: (2020-12-01)

Study on the Role and Mechanism of METTL3 Mediating the Up-regulation of  m6A Modified Long Non-coding RNA THAP7-AS1 in Promoting the Occurrence of  Lung Cancer
by: Yu ZHANG, et al.
Published: (2023-12-01)

Functional Characterization of Two RNA Methyltransferase Genes <i>METTL3</i> and <i>METTL14</i> Uncovers the Roles of m<sup>6</sup>A in Mediating Adaptation of <i>Plutella xylostella</i> to Host Plants
by: Bei-Bei Wang, et al.
Published: (2022-09-01)

The m6A Methyltransferase METTL3 Is Functionally Implicated in DLBCL Development by Regulating m6A Modification in PEDF
by: Yingying Cheng, et al.
Published: (2020-08-01)

The role of RNA methyltransferase METTL3 in gynecologic cancers: Results and mechanisms
by: Yuxiang Zhang, et al.
Published: (2023-03-01)

FOXO1 Regulates Bacteria-Induced Neutrophil Activity
by: Guangyu Dong, et al.
Published: (2017-09-01)

Loss of KMT2D induces prostate cancer ROS-mediated DNA damage by suppressing the enhancer activity and DNA binding of antioxidant transcription factor FOXO3
by: Shidong Lv, et al.
Published: (2019-12-01)

YTHDF1 Aggravates the Progression of Cervical Cancer Through m6A-Mediated Up-Regulation of RANBP2
by: Haocheng Wang, et al.
Published: (2021-03-01)

RNA Methyltransferase METTL16’s Protein Domains Have Differential Functional Effects on Cell Processes
by: Emily S. Talic, et al.
Published: (2023-06-01)

High stretch cycling inhibits the morphological and biological decidual process in human endometrial stromal cells
by: Ryohei Saito, et al.
Published: (2020-10-01)

The role of mRNA m6A methylation in the nervous system
by: Jiashuo Li, et al.
Published: (2019-08-01)

N6-methyladenosine reader YTHDF1 regulates the proliferation and migration of airway smooth muscle cells through m6A/cyclin D1 in asthma
by: Juan Wang, et al.
Published: (2023-03-01)

METTL3 regulates N6-methyladenosine modification of ANGPTL3 mRNA and potentiates malignant progression of stomach adenocarcinoma
by: Zhijin Zhang, et al.
Published: (2023-06-01)

METTL3 Is Involved in the Development of Graves’ Disease by Inducing SOCS mRNA m6A Modification
by: Rong-hua Song, et al.
Published: (2021-09-01)

Novel insights into mutual regulation between N6-methyladenosine modification and LncRNAs in tumors
by: Nan Zhang, et al.
Published: (2023-06-01)

Novel insights into the m6A-RNA methyltransferase METTL3 in cancer
by: Yiqing Cai, et al.
Published: (2021-04-01)

Forkhead box transcription factors (FOXOs and FOXM1) in glioma: from molecular mechanisms to therapeutics
by: Peyman Tabnak, et al.
Published: (2023-10-01)

Combination of Decitabine and Entinostat Synergistically Inhibits Urothelial Bladder Cancer Cells via Activation of FoxO1
by: Chenyin Wang, et al.
Published: (2020-02-01)

The Regulators of Human Endometrial Stromal Cell Decidualization
by: Hiromi Murata, et al.
Published: (2022-09-01)

The RNA m6A writer METTL3 in tumor microenvironment: emerging roles and therapeutic implications
by: Weiqi Su, et al.
Published: (2024-01-01)

Mucosal Immunity and the FOXO1 Transcription Factors
by: Dana T. Graves, et al.
Published: (2019-11-01)

Ythdf2-mediated m6A mRNA clearance modulates neural development in mice
by: Miaomiao Li, et al.
Published: (2018-05-01)

METTL14 Inhibits Hepatocellular Carcinoma Metastasis Through Regulating EGFR/PI3K/AKT Signaling Pathway in an m6A-Dependent Manner
by: Shi Y, et al.
Published: (2020-12-01)

YTHDF2 alleviates cardiac hypertrophy via regulating Myh7 mRNA decoy
by: Hongfei Xu, et al.
Published: (2021-07-01)

Expression and Regulation of a Novel Decidual Cells-Derived Estrogen Target during Decidualization
by: Lin Lu, et al.
Published: (2022-12-01)

METTL3/m6A/IFIT2 regulates proliferation, invasion and immunity in esophageal squamous cell carcinoma
by: Fangfang Ge, et al.
Published: (2022-10-01)

Linalool Prevents Cisplatin Induced Muscle Atrophy by Regulating IGF-1/Akt/FoxO Pathway
by: Hong Zhang, et al.
Published: (2020-11-01)

YTHDF1 Facilitates the Progression of Hepatocellular Carcinoma by Promoting FZD5 mRNA Translation in an m6A-Dependent Manner
by: Xiangxiang Liu, et al.
Published: (2020-12-01)