Potential neuropsychological mechanism involved in the transition from suicide ideation to action – a resting-state fMRI study implicating the insula
Abstract Background Understanding the neural mechanism underlying the transition from suicidal ideation to action is crucial but remains unclear. To explore this mechanism, we combined resting-state functional connectivity (rsFC) and computational modeling to investigate differences between those wh...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2023-01-01
|
| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933823024446/type/journal_article |
| _version_ | 1827809196752502784 |
|---|---|
| author | Shulin Fang Samuel F. Law Xinlei Ji Qinyu Liu Panwen Zhang Runqing Zhong Huanhuan Li Xiaosheng Wang Shuqiao Yao Xiang Wang |
| author_facet | Shulin Fang Samuel F. Law Xinlei Ji Qinyu Liu Panwen Zhang Runqing Zhong Huanhuan Li Xiaosheng Wang Shuqiao Yao Xiang Wang |
| author_sort | Shulin Fang |
| collection | DOAJ |
| description | Abstract
Background
Understanding the neural mechanism underlying the transition from suicidal ideation to action is crucial but remains unclear. To explore this mechanism, we combined resting-state functional connectivity (rsFC) and computational modeling to investigate differences between those who attempted suicide(SA) and those who hold only high levels of suicidal ideation(HSI).
Methods
A total of 120 MDD patients were categorized into SA group (n=47) and HSI group (n=73). All participants completed a resting-state functional MRI scan, with three subregions of the insula and the dorsal anterior cingulate cortex (dACC) being chosen as the region of interest (ROI) in seed-to-voxel analyses. Additionally, 86 participants completed the balloon analogue risk task (BART), and a five-parameter Bayesian modeling of BART was estimated.
Results
In the SA group, the FC between the ventral anterior insula (vAI) and the superior/middle frontal gyrus (vAI-SFG, vAI-MFG), as well as the FC between posterior insula (pI) and MFG (pI-MFG), were lower than those in HSI group. The correlation analysis showed a negative correlation between the FC of vAI-SFG and psychological pain avoidance in SA group, whereas a positive correlation in HSI group. Furthermore, the FC of vAI-MFG displayed a negative correlation with loss aversion in SA group, while a positive correlation was found with psychological pain avoidance in HSI group.
Conclusion
In current study, two distinct neural mechanisms were identified in the insula which involving in the progression from suicidal ideation to action. Dysfunction in vAI FCs may gradually stabilize as individuals experience heightened psychological pain, and a shift from positive to negative correlation patterns of vAI-MFC may indicate a transition from state to trait impairment. Additionally, the dysfunction in PI FC may lead to a lowered threshold for suicide by blunting the perception of physical harm.
|
| first_indexed | 2024-03-11T22:39:22Z |
| format | Article |
| id | doaj.art-f5892a7d33604970bf0445b8196af82b |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T22:39:22Z |
| publishDate | 2023-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-f5892a7d33604970bf0445b8196af82b2023-09-22T10:20:44ZengCambridge University PressEuropean Psychiatry0924-93381778-35852023-01-016610.1192/j.eurpsy.2023.2444Potential neuropsychological mechanism involved in the transition from suicide ideation to action – a resting-state fMRI study implicating the insulaShulin Fang0https://orcid.org/0000-0003-2820-8527Samuel F. Law1https://orcid.org/0000-0002-1918-8782Xinlei Ji2https://orcid.org/0000-0002-1133-9582Qinyu Liu3https://orcid.org/0000-0003-1793-6035Panwen Zhang4https://orcid.org/0000-0002-8696-2715Runqing Zhong5Huanhuan Li6Xiaosheng Wang7Shuqiao Yao8Xiang Wang9Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China China National Clinical Research Center on Mental Disorders (Xiangya), Changsha, Hunan, ChinaDepartment of Psychiatry, University of Toronto, Toronto, Ontario, CanadaMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China China National Clinical Research Center on Mental Disorders (Xiangya), Changsha, Hunan, ChinaMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China China National Clinical Research Center on Mental Disorders (Xiangya), Changsha, Hunan, ChinaMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China Shanghai Songjiang Jiuting Middle School, Shanghai, ChinaMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China China National Clinical Research Center on Mental Disorders (Xiangya), Changsha, Hunan, ChinaDepartment of Psychology, Renmin University of China, Beijing, ChinaDepartment of Human Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Hunan, ChinaMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China China National Clinical Research Center on Mental Disorders (Xiangya), Changsha, Hunan, ChinaMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China China National Clinical Research Center on Mental Disorders (Xiangya), Changsha, Hunan, ChinaAbstract Background Understanding the neural mechanism underlying the transition from suicidal ideation to action is crucial but remains unclear. To explore this mechanism, we combined resting-state functional connectivity (rsFC) and computational modeling to investigate differences between those who attempted suicide(SA) and those who hold only high levels of suicidal ideation(HSI). Methods A total of 120 MDD patients were categorized into SA group (n=47) and HSI group (n=73). All participants completed a resting-state functional MRI scan, with three subregions of the insula and the dorsal anterior cingulate cortex (dACC) being chosen as the region of interest (ROI) in seed-to-voxel analyses. Additionally, 86 participants completed the balloon analogue risk task (BART), and a five-parameter Bayesian modeling of BART was estimated. Results In the SA group, the FC between the ventral anterior insula (vAI) and the superior/middle frontal gyrus (vAI-SFG, vAI-MFG), as well as the FC between posterior insula (pI) and MFG (pI-MFG), were lower than those in HSI group. The correlation analysis showed a negative correlation between the FC of vAI-SFG and psychological pain avoidance in SA group, whereas a positive correlation in HSI group. Furthermore, the FC of vAI-MFG displayed a negative correlation with loss aversion in SA group, while a positive correlation was found with psychological pain avoidance in HSI group. Conclusion In current study, two distinct neural mechanisms were identified in the insula which involving in the progression from suicidal ideation to action. Dysfunction in vAI FCs may gradually stabilize as individuals experience heightened psychological pain, and a shift from positive to negative correlation patterns of vAI-MFC may indicate a transition from state to trait impairment. Additionally, the dysfunction in PI FC may lead to a lowered threshold for suicide by blunting the perception of physical harm. https://www.cambridge.org/core/product/identifier/S0924933823024446/type/journal_articledecision-makingideation-to-action frameworkinsularesting-state fMRIsuicide |
| spellingShingle | Shulin Fang Samuel F. Law Xinlei Ji Qinyu Liu Panwen Zhang Runqing Zhong Huanhuan Li Xiaosheng Wang Shuqiao Yao Xiang Wang Potential neuropsychological mechanism involved in the transition from suicide ideation to action – a resting-state fMRI study implicating the insula European Psychiatry decision-making ideation-to-action framework insula resting-state fMRI suicide |
| title | Potential neuropsychological mechanism involved in the transition from suicide ideation to action – a resting-state fMRI study implicating the insula |
| title_full | Potential neuropsychological mechanism involved in the transition from suicide ideation to action – a resting-state fMRI study implicating the insula |
| title_fullStr | Potential neuropsychological mechanism involved in the transition from suicide ideation to action – a resting-state fMRI study implicating the insula |
| title_full_unstemmed | Potential neuropsychological mechanism involved in the transition from suicide ideation to action – a resting-state fMRI study implicating the insula |
| title_short | Potential neuropsychological mechanism involved in the transition from suicide ideation to action – a resting-state fMRI study implicating the insula |
| title_sort | potential neuropsychological mechanism involved in the transition from suicide ideation to action a resting state fmri study implicating the insula |
| topic | decision-making ideation-to-action framework insula resting-state fMRI suicide |
| url | https://www.cambridge.org/core/product/identifier/S0924933823024446/type/journal_article |
| work_keys_str_mv | AT shulinfang potentialneuropsychologicalmechanisminvolvedinthetransitionfromsuicideideationtoactionarestingstatefmristudyimplicatingtheinsula AT samuelflaw potentialneuropsychologicalmechanisminvolvedinthetransitionfromsuicideideationtoactionarestingstatefmristudyimplicatingtheinsula AT xinleiji potentialneuropsychologicalmechanisminvolvedinthetransitionfromsuicideideationtoactionarestingstatefmristudyimplicatingtheinsula AT qinyuliu potentialneuropsychologicalmechanisminvolvedinthetransitionfromsuicideideationtoactionarestingstatefmristudyimplicatingtheinsula AT panwenzhang potentialneuropsychologicalmechanisminvolvedinthetransitionfromsuicideideationtoactionarestingstatefmristudyimplicatingtheinsula AT runqingzhong potentialneuropsychologicalmechanisminvolvedinthetransitionfromsuicideideationtoactionarestingstatefmristudyimplicatingtheinsula AT huanhuanli potentialneuropsychologicalmechanisminvolvedinthetransitionfromsuicideideationtoactionarestingstatefmristudyimplicatingtheinsula AT xiaoshengwang potentialneuropsychologicalmechanisminvolvedinthetransitionfromsuicideideationtoactionarestingstatefmristudyimplicatingtheinsula AT shuqiaoyao potentialneuropsychologicalmechanisminvolvedinthetransitionfromsuicideideationtoactionarestingstatefmristudyimplicatingtheinsula AT xiangwang potentialneuropsychologicalmechanisminvolvedinthetransitionfromsuicideideationtoactionarestingstatefmristudyimplicatingtheinsula |