Prophylactic role of ciprofloxacin and ceftriaxone in prostate biopsy-related infection: randomized comparative study of bacterial spectrum and antibiotic sensitivities
Abstract Background The mainstay for the diagnosis of prostate cancer is transrectal ultrasound-guided prostate biopsy. However, prostate biopsy is associated with a significant risk of complications including urinary tract infection. This study aims to compare the bacterial profile and antibiotic s...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-12-01
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| Series: | African Journal of Urology |
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| Online Access: | https://doi.org/10.1186/s12301-021-00258-3 |
| _version_ | 1829488782142865408 |
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| author | Chinonso Odo Emmanuel Nwali Afogu Charles Azuwuike Odoemene Anselm Okwudili Obi Timothy Uzoma Mbaeri Emmanuel Ahuizechukwu Obiesie Chike John Okeke Ugochukwu Uzodimma Nnadozie Augustine Obasi Ulebe |
| author_facet | Chinonso Odo Emmanuel Nwali Afogu Charles Azuwuike Odoemene Anselm Okwudili Obi Timothy Uzoma Mbaeri Emmanuel Ahuizechukwu Obiesie Chike John Okeke Ugochukwu Uzodimma Nnadozie Augustine Obasi Ulebe |
| author_sort | Chinonso Odo |
| collection | DOAJ |
| description | Abstract Background The mainstay for the diagnosis of prostate cancer is transrectal ultrasound-guided prostate biopsy. However, prostate biopsy is associated with a significant risk of complications including urinary tract infection. This study aims to compare the bacterial profile and antibiotic susceptibility pattern in urinary tract infection after prostate biopsy between patients on 2 different antimicrobial prophylactic regimens. Methods This was a comparative cross-sectional study done at the urology unit of our institution, over 13 months. Fifty-six patients who met the inclusion criteria made up the study population and were randomly assigned to two groups. Those in group 1 (28) received intravenous ciprofloxacin (Juhel) 400 mg at induction of anesthesia, while those in group 2 (28) received intravenous ceftriaxone (Rocephin) 1 g at induction of anesthesia. All patients received bisacodyl (dulcolax) rectal suppositories 20 mg nocte starting 2 nights before the procedure as well as intravenous metronidazole (Juhel) at induction of anesthesia. Urine samples were taken for urine culture and sensitivity three days after biopsy. Isolated organisms and their antibiotics sensitivities were documented. Statistical analysis was done using SPSS version 21.0 with the level of significance set at P < 0.05. Results In group 1 the prevalence of urinary tract infection was 61%. Escherichia coli was isolated in 11(64.71%) cases, Klebsiella species in 3(17.65%), staphylococcus aureus in 1(5.88%), Proteus species in 1(5.88%), and non-hemolytic streptococcus species in 1(5.88%). In this group, all isolated bacterial organisms were resistant to ciprofloxacin. In group 2 the prevalence of urinary tract infection was 43%. Klebsiella spp was isolated in 6(50%) cases, Pseudomonas aeruginosa in 3(25%), E. coli in 2(16.67%), Staphylococcus in 1(8.33%). In group 2 all isolated bacterial organisms were resistant to ceftriaxone. Conclusion Ciprofloxacin and ceftriaxone are both associated with a high rate of urinary tract infection when used as prophylaxis for prostate biopsy. The bacterial etiology of prostate biopsy-related urinary tract infection is dependent on the prophylactic antibiotics used. Based on the high rate of urinary tract infection associated with the use of either ciprofloxacin or ceftriaxone, we recommend a combination of both drugs as prophylaxis for prostate biopsy. |
| first_indexed | 2024-12-14T23:56:26Z |
| format | Article |
| id | doaj.art-f589a688af684a0d9984d251d39bc017 |
| institution | Directory Open Access Journal |
| issn | 1110-5704 1961-9987 |
| language | English |
| last_indexed | 2024-12-14T23:56:26Z |
| publishDate | 2021-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | African Journal of Urology |
| spelling | doaj.art-f589a688af684a0d9984d251d39bc0172022-12-21T22:43:06ZengSpringerOpenAfrican Journal of Urology1110-57041961-99872021-12-012711610.1186/s12301-021-00258-3Prophylactic role of ciprofloxacin and ceftriaxone in prostate biopsy-related infection: randomized comparative study of bacterial spectrum and antibiotic sensitivitiesChinonso Odo0Emmanuel Nwali Afogu1Charles Azuwuike Odoemene2Anselm Okwudili Obi3Timothy Uzoma Mbaeri4Emmanuel Ahuizechukwu Obiesie5Chike John Okeke6Ugochukwu Uzodimma Nnadozie7Augustine Obasi Ulebe8Department of Surgery, Alex-Ekwueme Federal University Teaching Hospital AbakalikiDepartment of Surgery, Alex-Ekwueme Federal University Teaching Hospital AbakalikiDepartment of Surgery, Alex-Ekwueme Federal University Teaching Hospital AbakalikiDepartment of Surgery, Alex-Ekwueme Federal University Teaching Hospital AbakalikiDepartment of Surgery, Nnamdi Azikiwe University Teaching Hospital NnewiDepartment of Surgery, Nnamdi Azikiwe University Teaching Hospital NnewiDepartment of Surgery, Alex-Ekwueme Federal University Teaching Hospital AbakalikiDepartment of Surgery, Alex-Ekwueme Federal University Teaching Hospital AbakalikiDepartment of Surgery, Alex-Ekwueme Federal University Teaching Hospital AbakalikiAbstract Background The mainstay for the diagnosis of prostate cancer is transrectal ultrasound-guided prostate biopsy. However, prostate biopsy is associated with a significant risk of complications including urinary tract infection. This study aims to compare the bacterial profile and antibiotic susceptibility pattern in urinary tract infection after prostate biopsy between patients on 2 different antimicrobial prophylactic regimens. Methods This was a comparative cross-sectional study done at the urology unit of our institution, over 13 months. Fifty-six patients who met the inclusion criteria made up the study population and were randomly assigned to two groups. Those in group 1 (28) received intravenous ciprofloxacin (Juhel) 400 mg at induction of anesthesia, while those in group 2 (28) received intravenous ceftriaxone (Rocephin) 1 g at induction of anesthesia. All patients received bisacodyl (dulcolax) rectal suppositories 20 mg nocte starting 2 nights before the procedure as well as intravenous metronidazole (Juhel) at induction of anesthesia. Urine samples were taken for urine culture and sensitivity three days after biopsy. Isolated organisms and their antibiotics sensitivities were documented. Statistical analysis was done using SPSS version 21.0 with the level of significance set at P < 0.05. Results In group 1 the prevalence of urinary tract infection was 61%. Escherichia coli was isolated in 11(64.71%) cases, Klebsiella species in 3(17.65%), staphylococcus aureus in 1(5.88%), Proteus species in 1(5.88%), and non-hemolytic streptococcus species in 1(5.88%). In this group, all isolated bacterial organisms were resistant to ciprofloxacin. In group 2 the prevalence of urinary tract infection was 43%. Klebsiella spp was isolated in 6(50%) cases, Pseudomonas aeruginosa in 3(25%), E. coli in 2(16.67%), Staphylococcus in 1(8.33%). In group 2 all isolated bacterial organisms were resistant to ceftriaxone. Conclusion Ciprofloxacin and ceftriaxone are both associated with a high rate of urinary tract infection when used as prophylaxis for prostate biopsy. The bacterial etiology of prostate biopsy-related urinary tract infection is dependent on the prophylactic antibiotics used. Based on the high rate of urinary tract infection associated with the use of either ciprofloxacin or ceftriaxone, we recommend a combination of both drugs as prophylaxis for prostate biopsy.https://doi.org/10.1186/s12301-021-00258-3Prostate biopsyFluoroquinolone resistancePost-biopsy urine culture |
| spellingShingle | Chinonso Odo Emmanuel Nwali Afogu Charles Azuwuike Odoemene Anselm Okwudili Obi Timothy Uzoma Mbaeri Emmanuel Ahuizechukwu Obiesie Chike John Okeke Ugochukwu Uzodimma Nnadozie Augustine Obasi Ulebe Prophylactic role of ciprofloxacin and ceftriaxone in prostate biopsy-related infection: randomized comparative study of bacterial spectrum and antibiotic sensitivities African Journal of Urology Prostate biopsy Fluoroquinolone resistance Post-biopsy urine culture |
| title | Prophylactic role of ciprofloxacin and ceftriaxone in prostate biopsy-related infection: randomized comparative study of bacterial spectrum and antibiotic sensitivities |
| title_full | Prophylactic role of ciprofloxacin and ceftriaxone in prostate biopsy-related infection: randomized comparative study of bacterial spectrum and antibiotic sensitivities |
| title_fullStr | Prophylactic role of ciprofloxacin and ceftriaxone in prostate biopsy-related infection: randomized comparative study of bacterial spectrum and antibiotic sensitivities |
| title_full_unstemmed | Prophylactic role of ciprofloxacin and ceftriaxone in prostate biopsy-related infection: randomized comparative study of bacterial spectrum and antibiotic sensitivities |
| title_short | Prophylactic role of ciprofloxacin and ceftriaxone in prostate biopsy-related infection: randomized comparative study of bacterial spectrum and antibiotic sensitivities |
| title_sort | prophylactic role of ciprofloxacin and ceftriaxone in prostate biopsy related infection randomized comparative study of bacterial spectrum and antibiotic sensitivities |
| topic | Prostate biopsy Fluoroquinolone resistance Post-biopsy urine culture |
| url | https://doi.org/10.1186/s12301-021-00258-3 |
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