<i>Helicobacter pylori</i> Infection in Children with Phenylketonuria Does Not Depend on Metabolic Control and Is Not More Frequent Than in Healthy Subjects—A Cross-Sectional Study
In a small preliminary study, phenylketonuria and poor metabolic control were suggested as risk factors for <i>Helicobacter pylori</i> infection in children as detected with an antigen stool test. We aimed to determine <i>Helicobacter pylori</i> prevalence in an adequately si...
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| Format: | Article |
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MDPI AG
2021-08-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/8/8/713 |
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| author | Marek Walkowiak Łukasz Kałużny Renata Mozrzymas Małgorzata Jamka Bożena Mikołuć Joanna Jagłowska Ewa Starostecka Roza Nurgaliyeva Jarosław Walkowiak Aleksandra Lisowska |
| author_facet | Marek Walkowiak Łukasz Kałużny Renata Mozrzymas Małgorzata Jamka Bożena Mikołuć Joanna Jagłowska Ewa Starostecka Roza Nurgaliyeva Jarosław Walkowiak Aleksandra Lisowska |
| author_sort | Marek Walkowiak |
| collection | DOAJ |
| description | In a small preliminary study, phenylketonuria and poor metabolic control were suggested as risk factors for <i>Helicobacter pylori</i> infection in children as detected with an antigen stool test. We aimed to determine <i>Helicobacter pylori</i> prevalence in an adequately sized group of individuals with phenylketonuria and healthy subjects using the standard gold test (urea breath test). Further, we correlated <i>Helicobacter pylori</i> infection with metabolic control. The study comprised 103 individuals with phenylketonuria and 103 healthy subjects on whom a <sup>13</sup>C urea breath test was performed. Blood phenylalanine levels in the preceding year were analysed. The infection rate did not differ between individuals with phenylketonuria and healthy subjects (10.7% vs 15.5%; <i>p</i> = 0.41). The frequency of testing and phenylalanine concentrations of <i>Helicobacter pylori</i>-positive and <i>Helicobacter pylori</i>-negative patients with phenylketonuria did not differ (<i>p</i> = 0.92 and <i>p</i> = 0.54, respectively). No associations were detected for body mass index or metabolic control. Forward stepwise regression models revealed that age (<i>p =</i> 0.0009–0.0016) was the only independent correlate of <i>Helicobacter pylori</i> infection with a relatively low fraction of the variability of the condition being explained (adjR<sup>2</sup> = 0.0721–0.0754; model <i>p</i> = 0.020–0.023). In conclusion, <i>Helicobacter pylori</i> infection in phenylketonuria is not more frequent than in the general population. Moreover, it does not depend on metabolic control. |
| first_indexed | 2024-03-10T08:55:04Z |
| format | Article |
| id | doaj.art-f58af81abdec4568a743471fceb87128 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T08:55:04Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-f58af81abdec4568a743471fceb871282023-11-22T07:14:50ZengMDPI AGChildren2227-90672021-08-018871310.3390/children8080713<i>Helicobacter pylori</i> Infection in Children with Phenylketonuria Does Not Depend on Metabolic Control and Is Not More Frequent Than in Healthy Subjects—A Cross-Sectional StudyMarek Walkowiak0Łukasz Kałużny1Renata Mozrzymas2Małgorzata Jamka3Bożena Mikołuć4Joanna Jagłowska5Ewa Starostecka6Roza Nurgaliyeva7Jarosław Walkowiak8Aleksandra Lisowska9Department of Reproduction, Poznan University of Medical Sciences, Polna Str. 33, 60-535 Poznan, PolandDepartment of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna Str. 27/33, 60-572 Poznan, PolandResearch and Development Center, Regional Specialist Hospital, Kamieńskiego Str. 73a, 51-124 Wrocław, PolandDepartment of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna Str. 27/33, 60-572 Poznan, PolandDepartment of Pediatrics, Rheumatology, Immunology and Metabolic Bone Diseases, Medical University of Bialystok, Waszyngtona Str. 17, 15-274 Bialystok, PolandDepartment of Pediatrics, Hematology and Oncology, Medical University of Gdansk, Dębinki Str. 7, 80-211 Gdansk, PolandThe Regional Center of Rare Diseases, Polish Mother’s Memorial Hospital Research Institute, Rzgowska Str. 281/289, 93-338 Łodź, PolandDepartment of Normal Physiology, West Kazakhstan Marat Ospanov Medical University, Maresyev Str. 68, Aktobe 030019, KazakhstanDepartment of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna Str. 27/33, 60-572 Poznan, PolandDepartment of Clinical Auxology and Pediatric Nursing, Poznan University of Medical Sciences, Szpitalna Str. 27/33, 60-572 Poznan, PolandIn a small preliminary study, phenylketonuria and poor metabolic control were suggested as risk factors for <i>Helicobacter pylori</i> infection in children as detected with an antigen stool test. We aimed to determine <i>Helicobacter pylori</i> prevalence in an adequately sized group of individuals with phenylketonuria and healthy subjects using the standard gold test (urea breath test). Further, we correlated <i>Helicobacter pylori</i> infection with metabolic control. The study comprised 103 individuals with phenylketonuria and 103 healthy subjects on whom a <sup>13</sup>C urea breath test was performed. Blood phenylalanine levels in the preceding year were analysed. The infection rate did not differ between individuals with phenylketonuria and healthy subjects (10.7% vs 15.5%; <i>p</i> = 0.41). The frequency of testing and phenylalanine concentrations of <i>Helicobacter pylori</i>-positive and <i>Helicobacter pylori</i>-negative patients with phenylketonuria did not differ (<i>p</i> = 0.92 and <i>p</i> = 0.54, respectively). No associations were detected for body mass index or metabolic control. Forward stepwise regression models revealed that age (<i>p =</i> 0.0009–0.0016) was the only independent correlate of <i>Helicobacter pylori</i> infection with a relatively low fraction of the variability of the condition being explained (adjR<sup>2</sup> = 0.0721–0.0754; model <i>p</i> = 0.020–0.023). In conclusion, <i>Helicobacter pylori</i> infection in phenylketonuria is not more frequent than in the general population. Moreover, it does not depend on metabolic control.https://www.mdpi.com/2227-9067/8/8/713inborn errors of metabolismphenylalaninepaediatricsanthropometry |
| spellingShingle | Marek Walkowiak Łukasz Kałużny Renata Mozrzymas Małgorzata Jamka Bożena Mikołuć Joanna Jagłowska Ewa Starostecka Roza Nurgaliyeva Jarosław Walkowiak Aleksandra Lisowska <i>Helicobacter pylori</i> Infection in Children with Phenylketonuria Does Not Depend on Metabolic Control and Is Not More Frequent Than in Healthy Subjects—A Cross-Sectional Study Children inborn errors of metabolism phenylalanine paediatrics anthropometry |
| title | <i>Helicobacter pylori</i> Infection in Children with Phenylketonuria Does Not Depend on Metabolic Control and Is Not More Frequent Than in Healthy Subjects—A Cross-Sectional Study |
| title_full | <i>Helicobacter pylori</i> Infection in Children with Phenylketonuria Does Not Depend on Metabolic Control and Is Not More Frequent Than in Healthy Subjects—A Cross-Sectional Study |
| title_fullStr | <i>Helicobacter pylori</i> Infection in Children with Phenylketonuria Does Not Depend on Metabolic Control and Is Not More Frequent Than in Healthy Subjects—A Cross-Sectional Study |
| title_full_unstemmed | <i>Helicobacter pylori</i> Infection in Children with Phenylketonuria Does Not Depend on Metabolic Control and Is Not More Frequent Than in Healthy Subjects—A Cross-Sectional Study |
| title_short | <i>Helicobacter pylori</i> Infection in Children with Phenylketonuria Does Not Depend on Metabolic Control and Is Not More Frequent Than in Healthy Subjects—A Cross-Sectional Study |
| title_sort | i helicobacter pylori i infection in children with phenylketonuria does not depend on metabolic control and is not more frequent than in healthy subjects a cross sectional study |
| topic | inborn errors of metabolism phenylalanine paediatrics anthropometry |
| url | https://www.mdpi.com/2227-9067/8/8/713 |
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