Effects of tetrahydroxy stilbene glycoside derivatives on free radical damage and apoptosis in APP695V717I transgenic mice
ABSTRACTMitochondrial dysfunction leading to overproduction of oxygen free radicals is an important event in the development of Alzheimer's disease. Tetrahydroxy stilbene glycoside (TSG) is one of the main effective components of Polygonum multiflorum and has a certain free radical scavenging e...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Redox Report |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/13510002.2023.2259246 |
| _version_ | 1797398807094231040 |
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| author | Jun Qian Yun Li Yanyun Wang Qunying Ye Hongbo Luo |
| author_facet | Jun Qian Yun Li Yanyun Wang Qunying Ye Hongbo Luo |
| author_sort | Jun Qian |
| collection | DOAJ |
| description | ABSTRACTMitochondrial dysfunction leading to overproduction of oxygen free radicals is an important event in the development of Alzheimer's disease. Tetrahydroxy stilbene glycoside (TSG) is one of the main effective components of Polygonum multiflorum and has a certain free radical scavenging effect. We synthesized tetrahydroxy stilbene glycoside derivatives (Mito-TSGs) that can cross the mitochondrial membrane and may provide effective protection against Alzheimer's disease. This experiment investigates the protective mechanism of tetrahydroxy stilbene glycoside derivatives against mitochondrial free radical damage and apoptosis in APP695V717I transgenic model mice. The experimental subjects were healthy 3-month-old APP695V717I transgenic model mice, while C57BL/6J mice of the same age and genetic background served as controls. The results demonstrated that the tetrahydroxy stilbene glycoside derivatives significantly improved mouse behavioral performance. It also led to a decrease in the levels of H2O2, NO, MDA, and LD, along with an increase in LDH activity and in the antioxidant enzyme activity of SOD, CAT, and GSH-Px. Moreover, it elevated the mitochondrial membrane potential, decreased the gene and protein expression of Caspase-3 and Bax, and increased the gene and protein expression of Bcl-2. Notably, the effectiveness of tetrahydroxy stilbene glycoside derivatives was superior to that of traditional tetrahydroxy stilbene glycoside. |
| first_indexed | 2024-03-09T01:30:51Z |
| format | Article |
| id | doaj.art-f58c69ec0a2b4817afb7087afae5fadf |
| institution | Directory Open Access Journal |
| issn | 1351-0002 1743-2928 |
| language | English |
| last_indexed | 2024-03-09T01:30:51Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Redox Report |
| spelling | doaj.art-f58c69ec0a2b4817afb7087afae5fadf2023-12-09T20:05:02ZengTaylor & Francis GroupRedox Report1351-00021743-29282023-12-0128110.1080/13510002.2023.2259246Effects of tetrahydroxy stilbene glycoside derivatives on free radical damage and apoptosis in APP695V717I transgenic miceJun Qian0Yun Li1Yanyun Wang2Qunying Ye3Hongbo Luo4Department of Neurology, Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai, People’s Republic of ChinaDepartment of Nephrology, Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai, People’s Republic of ChinaDepartment of Neurology, Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai, People’s Republic of ChinaDepartment of Neurology, Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai, People’s Republic of ChinaDepartment of Neurology, Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai, People’s Republic of ChinaABSTRACTMitochondrial dysfunction leading to overproduction of oxygen free radicals is an important event in the development of Alzheimer's disease. Tetrahydroxy stilbene glycoside (TSG) is one of the main effective components of Polygonum multiflorum and has a certain free radical scavenging effect. We synthesized tetrahydroxy stilbene glycoside derivatives (Mito-TSGs) that can cross the mitochondrial membrane and may provide effective protection against Alzheimer's disease. This experiment investigates the protective mechanism of tetrahydroxy stilbene glycoside derivatives against mitochondrial free radical damage and apoptosis in APP695V717I transgenic model mice. The experimental subjects were healthy 3-month-old APP695V717I transgenic model mice, while C57BL/6J mice of the same age and genetic background served as controls. The results demonstrated that the tetrahydroxy stilbene glycoside derivatives significantly improved mouse behavioral performance. It also led to a decrease in the levels of H2O2, NO, MDA, and LD, along with an increase in LDH activity and in the antioxidant enzyme activity of SOD, CAT, and GSH-Px. Moreover, it elevated the mitochondrial membrane potential, decreased the gene and protein expression of Caspase-3 and Bax, and increased the gene and protein expression of Bcl-2. Notably, the effectiveness of tetrahydroxy stilbene glycoside derivatives was superior to that of traditional tetrahydroxy stilbene glycoside.https://www.tandfonline.com/doi/10.1080/13510002.2023.2259246Alzheimer’s diseasetetrahydroxy stilbene glycoside derivativesfree radical damagemitochondrial targeting compoundsoxidative stressapoptosis |
| spellingShingle | Jun Qian Yun Li Yanyun Wang Qunying Ye Hongbo Luo Effects of tetrahydroxy stilbene glycoside derivatives on free radical damage and apoptosis in APP695V717I transgenic mice Redox Report Alzheimer’s disease tetrahydroxy stilbene glycoside derivatives free radical damage mitochondrial targeting compounds oxidative stress apoptosis |
| title | Effects of tetrahydroxy stilbene glycoside derivatives on free radical damage and apoptosis in APP695V717I transgenic mice |
| title_full | Effects of tetrahydroxy stilbene glycoside derivatives on free radical damage and apoptosis in APP695V717I transgenic mice |
| title_fullStr | Effects of tetrahydroxy stilbene glycoside derivatives on free radical damage and apoptosis in APP695V717I transgenic mice |
| title_full_unstemmed | Effects of tetrahydroxy stilbene glycoside derivatives on free radical damage and apoptosis in APP695V717I transgenic mice |
| title_short | Effects of tetrahydroxy stilbene glycoside derivatives on free radical damage and apoptosis in APP695V717I transgenic mice |
| title_sort | effects of tetrahydroxy stilbene glycoside derivatives on free radical damage and apoptosis in app695v717i transgenic mice |
| topic | Alzheimer’s disease tetrahydroxy stilbene glycoside derivatives free radical damage mitochondrial targeting compounds oxidative stress apoptosis |
| url | https://www.tandfonline.com/doi/10.1080/13510002.2023.2259246 |
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