Anticariogenic Activity of Three Essential Oils from Brazilian Piperaceae
The current trend toward using natural food additives, cosmetics, and medicines has motivated industries to substitute synthetic compounds for natural products. Essential oils (EOs) from medicinal plants are a well-known source of chemical compounds that display several interesting biological activi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/8/972 |
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| author | Êni S. Carvalho Vanessa F. S. Ayres Midiã R. Oliveira Geone M. Corrêa Renata Takeara Anderson C. Guimarães Mariana B. Santiago Thaís A. S. Oliveira Carlos H. G. Martins Antônio E. M. Crotti Eliane O. Silva |
| author_facet | Êni S. Carvalho Vanessa F. S. Ayres Midiã R. Oliveira Geone M. Corrêa Renata Takeara Anderson C. Guimarães Mariana B. Santiago Thaís A. S. Oliveira Carlos H. G. Martins Antônio E. M. Crotti Eliane O. Silva |
| author_sort | Êni S. Carvalho |
| collection | DOAJ |
| description | The current trend toward using natural food additives, cosmetics, and medicines has motivated industries to substitute synthetic compounds for natural products. Essential oils (EOs) from medicinal plants are a well-known source of chemical compounds that display several interesting biological activities, including antimicrobial action. In this study, we investigated the antibacterial activity of EOs extracted from three Piperaceae species collected in the Brazilian Amazon region against a representative panel of cariogenic bacteria. The minimum inhibitory concentration (MIC) of the essential oils extracted from <i>Peperomia pellucida</i> (PP-EO), <i>Piper marginatum</i> (PM-EO), and <i>Piper callosum</i> (PC-EO) was determined against <i>Streptococcus mutans</i>, <i>S. mitis</i>, <i>S. sanguinis</i>, <i>S. salivarius</i>, <i>S. sobrinus</i>, <i>Enterococcus faecalis</i>, and <i>Lactobacillus casei</i> by using the microplate microdilution method. PM-EO, PC-EO, and PP-EO displayed antibacterial activity against all the tested cariogenic bacteria. PM-EO displayed the best inhibitory activity, with MIC values ranging from 50 to 500 µg/mL. The lowest MIC values were obtained for PM-EO against <i>S. mitis</i> (MIC = 75 μg/mL), <i>Lactobacillus casei</i> (MIC = 50 μg/mL), and <i>S. mutans</i> (MIC = 50 μg/mL). Gas chromatography mass spectrometry (GC-MS) analysis allowed the chemical composition of all the EOs to be identified. The main constituents of PM-EO, PC-EO, and PP-EO were 3,4-(methylenedioxy)propiophenone, α-pinene, and dillapiole, respectively. Finally, the compounds that were exclusively detected in PM-EO are highlighted. Our results suggest that PM-EO may be used in products for treating dental caries and periodontal diseases. |
| first_indexed | 2024-03-09T03:59:02Z |
| format | Article |
| id | doaj.art-f590da6692a64c65bd28a2560e1f88de |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T03:59:02Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-f590da6692a64c65bd28a2560e1f88de2023-12-03T14:16:19ZengMDPI AGPharmaceuticals1424-82472022-08-0115897210.3390/ph15080972Anticariogenic Activity of Three Essential Oils from Brazilian PiperaceaeÊni S. Carvalho0Vanessa F. S. Ayres1Midiã R. Oliveira2Geone M. Corrêa3Renata Takeara4Anderson C. Guimarães5Mariana B. Santiago6Thaís A. S. Oliveira7Carlos H. G. Martins8Antônio E. M. Crotti9Eliane O. Silva10Departamento de Química Orgânica, Instituto de Química, Universidade Federal da Bahia, Salvador 40170-115, BrazilInstituto de Ciências Exatas e Tecnologia, Universidade Federal do Amazonas, Itacoatiara 69103-128, BrazilInstituto de Ciências Exatas e Tecnologia, Universidade Federal do Amazonas, Itacoatiara 69103-128, BrazilInstituto de Ciências Exatas e Tecnologia, Universidade Federal do Amazonas, Itacoatiara 69103-128, BrazilInstituto de Ciências Exatas e Tecnologia, Universidade Federal do Amazonas, Itacoatiara 69103-128, BrazilInstituto de Ciências Exatas, Universidade Federal do Amazonas, Manaus 69077-000, BrazilInstituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia 38405-318, BrazilDepartamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto 14040-901, BrazilInstituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia 38405-318, BrazilDepartamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto 14040-901, BrazilDepartamento de Química Orgânica, Instituto de Química, Universidade Federal da Bahia, Salvador 40170-115, BrazilThe current trend toward using natural food additives, cosmetics, and medicines has motivated industries to substitute synthetic compounds for natural products. Essential oils (EOs) from medicinal plants are a well-known source of chemical compounds that display several interesting biological activities, including antimicrobial action. In this study, we investigated the antibacterial activity of EOs extracted from three Piperaceae species collected in the Brazilian Amazon region against a representative panel of cariogenic bacteria. The minimum inhibitory concentration (MIC) of the essential oils extracted from <i>Peperomia pellucida</i> (PP-EO), <i>Piper marginatum</i> (PM-EO), and <i>Piper callosum</i> (PC-EO) was determined against <i>Streptococcus mutans</i>, <i>S. mitis</i>, <i>S. sanguinis</i>, <i>S. salivarius</i>, <i>S. sobrinus</i>, <i>Enterococcus faecalis</i>, and <i>Lactobacillus casei</i> by using the microplate microdilution method. PM-EO, PC-EO, and PP-EO displayed antibacterial activity against all the tested cariogenic bacteria. PM-EO displayed the best inhibitory activity, with MIC values ranging from 50 to 500 µg/mL. The lowest MIC values were obtained for PM-EO against <i>S. mitis</i> (MIC = 75 μg/mL), <i>Lactobacillus casei</i> (MIC = 50 μg/mL), and <i>S. mutans</i> (MIC = 50 μg/mL). Gas chromatography mass spectrometry (GC-MS) analysis allowed the chemical composition of all the EOs to be identified. The main constituents of PM-EO, PC-EO, and PP-EO were 3,4-(methylenedioxy)propiophenone, α-pinene, and dillapiole, respectively. Finally, the compounds that were exclusively detected in PM-EO are highlighted. Our results suggest that PM-EO may be used in products for treating dental caries and periodontal diseases.https://www.mdpi.com/1424-8247/15/8/972antibacterial activityoral pathogens<i>Piper callosum</i><i>Piper marginatum</i><i>Peperomia pellucida</i> |
| spellingShingle | Êni S. Carvalho Vanessa F. S. Ayres Midiã R. Oliveira Geone M. Corrêa Renata Takeara Anderson C. Guimarães Mariana B. Santiago Thaís A. S. Oliveira Carlos H. G. Martins Antônio E. M. Crotti Eliane O. Silva Anticariogenic Activity of Three Essential Oils from Brazilian Piperaceae Pharmaceuticals antibacterial activity oral pathogens <i>Piper callosum</i> <i>Piper marginatum</i> <i>Peperomia pellucida</i> |
| title | Anticariogenic Activity of Three Essential Oils from Brazilian Piperaceae |
| title_full | Anticariogenic Activity of Three Essential Oils from Brazilian Piperaceae |
| title_fullStr | Anticariogenic Activity of Three Essential Oils from Brazilian Piperaceae |
| title_full_unstemmed | Anticariogenic Activity of Three Essential Oils from Brazilian Piperaceae |
| title_short | Anticariogenic Activity of Three Essential Oils from Brazilian Piperaceae |
| title_sort | anticariogenic activity of three essential oils from brazilian piperaceae |
| topic | antibacterial activity oral pathogens <i>Piper callosum</i> <i>Piper marginatum</i> <i>Peperomia pellucida</i> |
| url | https://www.mdpi.com/1424-8247/15/8/972 |
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