Serum Adropin Levels in Patients on Hemodialysis
Adropin is a novel pleotropic peptide involved in energy homeostasis, with possible contribution to cardiovascular protection through production of nitric oxide and subsequent blood pressure regulation. Given that patients undergoing hemodialysis (HD) are related with high cardiovascular risk, hyper...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/11/4/337 |
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| author | Dijana Boric-Skaro Maja Mizdrak Mirko Luketin Dinko Martinovic Daria Tokic Marino Vilovic Daniela Supe-Domic Tina Ticinovic Kurir Josko Bozic |
| author_facet | Dijana Boric-Skaro Maja Mizdrak Mirko Luketin Dinko Martinovic Daria Tokic Marino Vilovic Daniela Supe-Domic Tina Ticinovic Kurir Josko Bozic |
| author_sort | Dijana Boric-Skaro |
| collection | DOAJ |
| description | Adropin is a novel pleotropic peptide involved in energy homeostasis, with possible contribution to cardiovascular protection through production of nitric oxide and subsequent blood pressure regulation. Given that patients undergoing hemodialysis (HD) are related with high cardiovascular risk, hyperlipidemia, chronic low-grade inflammation, and malnutrition the aim of our study was to investigate serum adropin levels in HD patients to evaluate possible associations with nutritional status and other relevant clinical and laboratory parameters. The study included 70 patients on HD and 60 healthy controls. Serum adropin levels were determined by an enzyme-linked immunosorbent assay in a commercially available diagnostic kit. Serum adropin levels were significantly lower in the HD group compared to the control group (2.20 ± 0.72 vs. 4.05 ± 0.93 ng/mL, <i>p</i> < 0.001). Moreover, there was a significant negative correlation with malnutrition-inflammation score (r = −0.476, <i>p</i> < 0.001), dialysis malnutrition score (r = −0.350, <i>p</i> = 0.003), HD duration (r = −0.305, <i>p</i> = 0.010), and high sensitivity C-reactive protein (hsCRP) (r = −0.646, <i>p</i> < 0.001). Additionally, there was a significant negative correlation between adropin levels and pre-dialysis systolic (r = −0.301, <i>p</i> = 0.011) and diastolic blood pressure (r = −0.299, <i>p</i> = 0.011). These results are implying that adropin is potentially involved in the pathophysiological mechanisms of chronic kidney disease (CKD)/HD and its complications. However, future larger scale longitudinal studies need to further address it. |
| first_indexed | 2024-03-10T12:26:37Z |
| format | Article |
| id | doaj.art-f5912a471ffd4cadb8e1d279eed1269b |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T12:26:37Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-f5912a471ffd4cadb8e1d279eed1269b2023-11-21T15:03:12ZengMDPI AGLife2075-17292021-04-0111433710.3390/life11040337Serum Adropin Levels in Patients on HemodialysisDijana Boric-Skaro0Maja Mizdrak1Mirko Luketin2Dinko Martinovic3Daria Tokic4Marino Vilovic5Daniela Supe-Domic6Tina Ticinovic Kurir7Josko Bozic8Department of Nephrology and Dialysis, University Hospital of Split, 21000 Split, CroatiaDepartment of Nephrology and Dialysis, University Hospital of Split, 21000 Split, CroatiaDepartment of Nephrology and Dialysis, University Hospital of Split, 21000 Split, CroatiaDepartment of Pathophysiology, University of Split School of Medicine, 21000 Split, CroatiaDepartment of Anesthesiology and Intensive Care, University Hospital of Split, 21000 Split, CroatiaDepartment of Pathophysiology, University of Split School of Medicine, 21000 Split, CroatiaDepartment of Health Studies, University of Split, 21000 Split, CroatiaDepartment of Pathophysiology, University of Split School of Medicine, 21000 Split, CroatiaDepartment of Pathophysiology, University of Split School of Medicine, 21000 Split, CroatiaAdropin is a novel pleotropic peptide involved in energy homeostasis, with possible contribution to cardiovascular protection through production of nitric oxide and subsequent blood pressure regulation. Given that patients undergoing hemodialysis (HD) are related with high cardiovascular risk, hyperlipidemia, chronic low-grade inflammation, and malnutrition the aim of our study was to investigate serum adropin levels in HD patients to evaluate possible associations with nutritional status and other relevant clinical and laboratory parameters. The study included 70 patients on HD and 60 healthy controls. Serum adropin levels were determined by an enzyme-linked immunosorbent assay in a commercially available diagnostic kit. Serum adropin levels were significantly lower in the HD group compared to the control group (2.20 ± 0.72 vs. 4.05 ± 0.93 ng/mL, <i>p</i> < 0.001). Moreover, there was a significant negative correlation with malnutrition-inflammation score (r = −0.476, <i>p</i> < 0.001), dialysis malnutrition score (r = −0.350, <i>p</i> = 0.003), HD duration (r = −0.305, <i>p</i> = 0.010), and high sensitivity C-reactive protein (hsCRP) (r = −0.646, <i>p</i> < 0.001). Additionally, there was a significant negative correlation between adropin levels and pre-dialysis systolic (r = −0.301, <i>p</i> = 0.011) and diastolic blood pressure (r = −0.299, <i>p</i> = 0.011). These results are implying that adropin is potentially involved in the pathophysiological mechanisms of chronic kidney disease (CKD)/HD and its complications. However, future larger scale longitudinal studies need to further address it.https://www.mdpi.com/2075-1729/11/4/337adropinhemodialysismalnutrition-inflammation scoredialysis malnutrition scorebody fat percentagelipid profile |
| spellingShingle | Dijana Boric-Skaro Maja Mizdrak Mirko Luketin Dinko Martinovic Daria Tokic Marino Vilovic Daniela Supe-Domic Tina Ticinovic Kurir Josko Bozic Serum Adropin Levels in Patients on Hemodialysis Life adropin hemodialysis malnutrition-inflammation score dialysis malnutrition score body fat percentage lipid profile |
| title | Serum Adropin Levels in Patients on Hemodialysis |
| title_full | Serum Adropin Levels in Patients on Hemodialysis |
| title_fullStr | Serum Adropin Levels in Patients on Hemodialysis |
| title_full_unstemmed | Serum Adropin Levels in Patients on Hemodialysis |
| title_short | Serum Adropin Levels in Patients on Hemodialysis |
| title_sort | serum adropin levels in patients on hemodialysis |
| topic | adropin hemodialysis malnutrition-inflammation score dialysis malnutrition score body fat percentage lipid profile |
| url | https://www.mdpi.com/2075-1729/11/4/337 |
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