Zoanthamine Alkaloids from the Zoantharian Zoanthus cf. pulchellus and Their Effects in Neuroinflammation
Two new zoanthamine alkaloids, namely 3-acetoxynorzoanthamine (1) and 3-acetoxyzoanthamine (2), have been isolated from the zoantharian Zoanthus cf. pulchellus collected off the coast of the Santa Elena Peninsula, Ecuador, together with three known derivatives: zoanthamine, norzoanthamine, and 3-hyd...
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MDPI AG
2018-07-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/16/7/242 |
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| author | Paul O. Guillen Sandra Gegunde Karla B. Jaramillo Amparo Alfonso Kevin Calabro Eva Alonso Jenny Rodriguez Luis M. Botana Olivier P. Thomas |
| author_facet | Paul O. Guillen Sandra Gegunde Karla B. Jaramillo Amparo Alfonso Kevin Calabro Eva Alonso Jenny Rodriguez Luis M. Botana Olivier P. Thomas |
| author_sort | Paul O. Guillen |
| collection | DOAJ |
| description | Two new zoanthamine alkaloids, namely 3-acetoxynorzoanthamine (1) and 3-acetoxyzoanthamine (2), have been isolated from the zoantharian Zoanthus cf. pulchellus collected off the coast of the Santa Elena Peninsula, Ecuador, together with three known derivatives: zoanthamine, norzoanthamine, and 3-hydroxynorzoanthamine. The chemical structures of 1 and 2 were determined by interpretation of their 1D and 2D NMR data and comparison with literature data. This is the first report of zoanthamine-type alkaloids from Zoanthus cf. pulchellus collected in the Tropical Eastern Pacific. The neuroinflammatory activity of all the isolated compounds was evaluated in microglia BV-2 cells and high inhibitory effects were observed in reactive oxygen species (ROS) and nitric oxide (NO) generation. |
| first_indexed | 2024-04-11T20:39:23Z |
| format | Article |
| id | doaj.art-f591671c47d44d299ced4a22a8baef92 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T20:39:23Z |
| publishDate | 2018-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-f591671c47d44d299ced4a22a8baef922022-12-22T04:04:17ZengMDPI AGMarine Drugs1660-33972018-07-0116724210.3390/md16070242md16070242Zoanthamine Alkaloids from the Zoantharian Zoanthus cf. pulchellus and Their Effects in NeuroinflammationPaul O. Guillen0Sandra Gegunde1Karla B. Jaramillo2Amparo Alfonso3Kevin Calabro4Eva Alonso5Jenny Rodriguez6Luis M. Botana7Olivier P. Thomas8ESPOL Escuela Superior Politécnica del Litoral, ESPOL, Centro Nacional de Acuacultura e Investigaciones Marinas, Campus Gustavo Galindo km. 30.5 vía Perimetral, P.O. Box 09-01-5863 Guayaquil, EcuadorDepartamento de Farmacología, Facultad de Veterinaria, Universidade de Santiago de Compostela, 27002 Lugo, SpainESPOL Escuela Superior Politécnica del Litoral, ESPOL, Centro Nacional de Acuacultura e Investigaciones Marinas, Campus Gustavo Galindo km. 30.5 vía Perimetral, P.O. Box 09-01-5863 Guayaquil, EcuadorDepartamento de Farmacología, Facultad de Veterinaria, Universidade de Santiago de Compostela, 27002 Lugo, SpainMarine Biodiscovery, School of Chemistry and Ryan Institute, National University of Ireland Galway (NUI Galway), University Road, H91 TK33 Galway, IrelandDepartamento de Farmacología, Facultad de Veterinaria, Universidade de Santiago de Compostela, 27002 Lugo, SpainESPOL Escuela Superior Politécnica del Litoral, ESPOL, Centro Nacional de Acuacultura e Investigaciones Marinas, Campus Gustavo Galindo km. 30.5 vía Perimetral, P.O. Box 09-01-5863 Guayaquil, EcuadorDepartamento de Farmacología, Facultad de Veterinaria, Universidade de Santiago de Compostela, 27002 Lugo, SpainMarine Biodiscovery, School of Chemistry and Ryan Institute, National University of Ireland Galway (NUI Galway), University Road, H91 TK33 Galway, IrelandTwo new zoanthamine alkaloids, namely 3-acetoxynorzoanthamine (1) and 3-acetoxyzoanthamine (2), have been isolated from the zoantharian Zoanthus cf. pulchellus collected off the coast of the Santa Elena Peninsula, Ecuador, together with three known derivatives: zoanthamine, norzoanthamine, and 3-hydroxynorzoanthamine. The chemical structures of 1 and 2 were determined by interpretation of their 1D and 2D NMR data and comparison with literature data. This is the first report of zoanthamine-type alkaloids from Zoanthus cf. pulchellus collected in the Tropical Eastern Pacific. The neuroinflammatory activity of all the isolated compounds was evaluated in microglia BV-2 cells and high inhibitory effects were observed in reactive oxygen species (ROS) and nitric oxide (NO) generation.http://www.mdpi.com/1660-3397/16/7/242zoanthariaTropical Eastern PacificZoanthus pulchelluszoanthamineinflammation |
| spellingShingle | Paul O. Guillen Sandra Gegunde Karla B. Jaramillo Amparo Alfonso Kevin Calabro Eva Alonso Jenny Rodriguez Luis M. Botana Olivier P. Thomas Zoanthamine Alkaloids from the Zoantharian Zoanthus cf. pulchellus and Their Effects in Neuroinflammation Marine Drugs zoantharia Tropical Eastern Pacific Zoanthus pulchellus zoanthamine inflammation |
| title | Zoanthamine Alkaloids from the Zoantharian Zoanthus cf. pulchellus and Their Effects in Neuroinflammation |
| title_full | Zoanthamine Alkaloids from the Zoantharian Zoanthus cf. pulchellus and Their Effects in Neuroinflammation |
| title_fullStr | Zoanthamine Alkaloids from the Zoantharian Zoanthus cf. pulchellus and Their Effects in Neuroinflammation |
| title_full_unstemmed | Zoanthamine Alkaloids from the Zoantharian Zoanthus cf. pulchellus and Their Effects in Neuroinflammation |
| title_short | Zoanthamine Alkaloids from the Zoantharian Zoanthus cf. pulchellus and Their Effects in Neuroinflammation |
| title_sort | zoanthamine alkaloids from the zoantharian zoanthus cf pulchellus and their effects in neuroinflammation |
| topic | zoantharia Tropical Eastern Pacific Zoanthus pulchellus zoanthamine inflammation |
| url | http://www.mdpi.com/1660-3397/16/7/242 |
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