Intestinal Alkaline Phosphatase: A Review of This Enzyme Role in the Intestinal Barrier Function
Intestinal alkaline phosphatase (IALP) has recently assumed a special relevance, being the subject of study in the prevention and treatment of certain diseases related to leaky gut. This brush border enzyme (ecto-enzyme) plays an important role in the maintenance of intestinal microbial homeostasis...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/10/4/746 |
| _version_ | 1827627575155884032 |
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| author | Gilberto Maia Santos Shámila Ismael Juliana Morais João R. Araújo Ana Faria Conceição Calhau Cláudia Marques |
| author_facet | Gilberto Maia Santos Shámila Ismael Juliana Morais João R. Araújo Ana Faria Conceição Calhau Cláudia Marques |
| author_sort | Gilberto Maia Santos |
| collection | DOAJ |
| description | Intestinal alkaline phosphatase (IALP) has recently assumed a special relevance, being the subject of study in the prevention and treatment of certain diseases related to leaky gut. This brush border enzyme (ecto-enzyme) plays an important role in the maintenance of intestinal microbial homeostasis and intestinal barrier function through its ability to dephosphorylate lipopolysaccharide (LPS). This review addresses how IALP and intestinal barrier dysfunction may be implicated in the pathophysiology of specific diseases such as inflammatory bowel disease, necrotizing enterocolitis, and metabolic syndrome. The use of IALP as a possible biomarker to assess intestinal barrier function and strategies to modulate IALP activity are also discussed. |
| first_indexed | 2024-03-09T13:17:00Z |
| format | Article |
| id | doaj.art-f5928f0baa4f471e9dd064bc0108e601 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T13:17:00Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-f5928f0baa4f471e9dd064bc0108e6012023-11-30T21:35:10ZengMDPI AGMicroorganisms2076-26072022-03-0110474610.3390/microorganisms10040746Intestinal Alkaline Phosphatase: A Review of This Enzyme Role in the Intestinal Barrier FunctionGilberto Maia Santos0Shámila Ismael1Juliana Morais2João R. Araújo3Ana Faria4Conceição Calhau5Cláudia Marques6Nutrition and Metabolism, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, 1169-056 Lisboa, PortugalNutrition and Metabolism, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, 1169-056 Lisboa, PortugalNutrition and Metabolism, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, 1169-056 Lisboa, PortugalNutrition and Metabolism, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, 1169-056 Lisboa, PortugalNutrition and Metabolism, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, 1169-056 Lisboa, PortugalNutrition and Metabolism, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, 1169-056 Lisboa, PortugalNutrition and Metabolism, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, 1169-056 Lisboa, PortugalIntestinal alkaline phosphatase (IALP) has recently assumed a special relevance, being the subject of study in the prevention and treatment of certain diseases related to leaky gut. This brush border enzyme (ecto-enzyme) plays an important role in the maintenance of intestinal microbial homeostasis and intestinal barrier function through its ability to dephosphorylate lipopolysaccharide (LPS). This review addresses how IALP and intestinal barrier dysfunction may be implicated in the pathophysiology of specific diseases such as inflammatory bowel disease, necrotizing enterocolitis, and metabolic syndrome. The use of IALP as a possible biomarker to assess intestinal barrier function and strategies to modulate IALP activity are also discussed.https://www.mdpi.com/2076-2607/10/4/746inflammatory bowel diseaseintestinal alkaline phosphataseintestinal barrier functionlow-grade chronic inflammationmetabolic dysfunctionnecrotizing enterocolitis |
| spellingShingle | Gilberto Maia Santos Shámila Ismael Juliana Morais João R. Araújo Ana Faria Conceição Calhau Cláudia Marques Intestinal Alkaline Phosphatase: A Review of This Enzyme Role in the Intestinal Barrier Function Microorganisms inflammatory bowel disease intestinal alkaline phosphatase intestinal barrier function low-grade chronic inflammation metabolic dysfunction necrotizing enterocolitis |
| title | Intestinal Alkaline Phosphatase: A Review of This Enzyme Role in the Intestinal Barrier Function |
| title_full | Intestinal Alkaline Phosphatase: A Review of This Enzyme Role in the Intestinal Barrier Function |
| title_fullStr | Intestinal Alkaline Phosphatase: A Review of This Enzyme Role in the Intestinal Barrier Function |
| title_full_unstemmed | Intestinal Alkaline Phosphatase: A Review of This Enzyme Role in the Intestinal Barrier Function |
| title_short | Intestinal Alkaline Phosphatase: A Review of This Enzyme Role in the Intestinal Barrier Function |
| title_sort | intestinal alkaline phosphatase a review of this enzyme role in the intestinal barrier function |
| topic | inflammatory bowel disease intestinal alkaline phosphatase intestinal barrier function low-grade chronic inflammation metabolic dysfunction necrotizing enterocolitis |
| url | https://www.mdpi.com/2076-2607/10/4/746 |
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