A Functional Human-on-a-Chip Autoimmune Disease Model of Myasthenia Gravis for Development of Therapeutics

A Functional Human-on-a-Chip Autoimmune Disease Model of Myasthenia Gravis for Development of Therapeutics

Myasthenia gravis (MG) is a chronic and progressive neuromuscular disease where autoantibodies target essential proteins such as the nicotinic acetylcholine receptor (nAChR) at the neuromuscular junction (NMJ) causing muscle fatigue and weakness. Autoantibodies directed against nAChRs are proposed t...

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Bibliographic Details
Main Authors: Virginia M. Smith, Huan Nguyen, John W. Rumsey, Christopher J. Long, Michael L. Shuler, James J. Hickman
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
acetylcholine receptor
neuromuscular junction (NMJ)
myasthenia gravis
autoantibodies
microphysiological systems
human-on-a-chip
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.745897/full

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